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  4. Recombinant Human Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3 (LRIT3), partial

Recombinant Human Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3 (LRIT3), partial

  • 中文名稱：
    人LRIT3重組蛋白
  • 貨號：
    CSB-YP663568HU1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人LRIT3重組蛋白
  • 貨號：
    CSB-EP663568HU1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人LRIT3重組蛋白
  • 貨號：
    CSB-EP663568HU1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人LRIT3重組蛋白
  • 貨號：
    CSB-BP663568HU1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人LRIT3重組蛋白
  • 貨號：
    CSB-MP663568HU1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    LRIT3
  • Uniprot No.：
  • 別名：
    LRIT3; Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Plays a role in the synapse formation and synaptic transmission between cone photoreceptor cells and retinal bipolar cells. Required for normal transmission of a light-evoked stimulus from the cone photoreceptor cells to the ON-bipolar cells and ON-ganglion cells in the inner retina. Required in retinal ON-bipolar cells for normal localization of the cation channel TRPM1 at dendrite tips. Seems to play a specific role in synaptic contacts made by ON-bipolar cells with cone photoreceptor pedicles. May also have a role in cone synapse formation. Might facilitate FGFR1 exit from the endoplasmic reticulum to the Golgi. Could be a regulator of the FGFRs.
  • 基因功能參考文獻：
    1. In this study, a novel compound heterozygous mutation, c.[1A>G]; [608G>T] (p.[0?]; p.[W203L]), was identified in the LRIT3 gene of a proband. No mutations were identified in the CABP4 or GPR179 gene. PMID: 27428514
    2. LRIT3 is likely involved in coordination of the transsynaptic communication between cones and ON-BCs during synapse formation and PMID: 28334377
    3. The exact role of this LRR protein in cCSNB remains to be elucidated. PMID: 23246293
    4. Observational study of gene-disease association. (HuGE Navigator) PMID: 20332099
  • 相關疾病：
    Night blindness, congenital stationary, 1F (CSNB1F)
  • 亞細胞定位：
    Cell projection, dendrite. Perikaryon. Endoplasmic reticulum membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Detected in the outer plexiform layer (OPL) of the retina where it localizes to ON-bipolar cells (at protein level).
  • 數據庫鏈接：

    HGNC: 24783

    OMIM: 615004

    KEGG: hsa:345193

    STRING: 9606.ENSP00000369252

    UniGene: Hs.308127



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