Recombinant Human Keratin, type II cuticular Hb1 (KRT81)

中文名稱：

人KRT81重組蛋白
貨號：

CSB-YP618893HU
規(guī)格：
來源：

Yeast
其他：

中文名稱：

人KRT81重組蛋白
貨號：

CSB-EP618893HU
規(guī)格：
來源：

E.coli
其他：

中文名稱：

人KRT81重組蛋白
貨號：

CSB-EP618893HU-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人KRT81重組蛋白
貨號：

CSB-BP618893HU
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

人KRT81重組蛋白
貨號：

CSB-MP618893HU
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

KRT81
Uniprot No.：

Q14533
別名：

1; basic; ghHb 1; ghHb1; ghHkb 1; ghHKb1; hair; Hair keratin K2.9; Hard keratin type II 1; HB 1; HB1; hHAKB2 1; K2.9; K81; Keratin 81; Keratin; Keratin hair basic 1; Keratin type II cuticular Hb1; Keratin-81; Keratin81; KRT 81; KRT81; KRT81_HUMAN; KRTHB 1; KRTHB1; Metastatic lymph node 137 gene protein; MLN 137; MLN137; type II cuticular Hb1; Type II hair keratin Hb1; Type-II keratin Kb21
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區(qū)域：

1-505
氨基酸序列

MTCGSGFGGR AFSCISACGP RPGRCCITAA PYRGISCYRG LTGGFGSHSV CGGFRAGSCG RSFGYRSGGV CGPSPPCITT VSVNESLLTP LNLEIDPNAQ CVKQEEKEQI KSLNSRFAAF IDKVRFLEQQ NKLLETKLQF YQNRECCQSN LEPLFEGYIE TLRREAECVE ADSGRLASEL NHVQEVLEGY KKKYEEEVSL RATAENEFVA LKKDVDCAYL RKSDLEANVE ALIQEIDFLR RLYEEEILIL QSHISDTSVV VKLDNSRDLN MDCIIAEIKA QYDDIVTRSR AEAESWYRSK CEEMKATVIR HGETLRRTKE EINELNRMIQ RLTAEVENAK CQNSKLEAAV AQSEQQGEAA LSDARCKLAE LEGALQKAKQ DMACLIREYQ EVMNSKLGLD IEIATYRRLL EGEEQRLCEG IGAVNVCVSS SRGGVVCGDL CVSGSRPVTG SVCSAPCNGN VAVSTGLCAP CGQLNTTCGG GSCGVGSCGI SSLGVGSCGS SCRKC
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

基因功能參考文獻：
1. Results show that full size KRT81 is expressed in normal breast epithelial cells and breast cancer cells, and indicate that KRT81 contributes to the migration and invasion of breast cancer cells. PMID: 28405679
2. The analysis of the KRT81rs3660G>C polymorphism may be useful to identify non-small cell lung cancer patients at high risk of a poor disease outcome. PMID: 25716425
3. Novel mutations causing monilethrix are reported in KRT81, KRT83, and KRT86. PMID: 25557232
4. MiRNA-related single nucleotide polymorphism sites of KRT81 is associated with non-Hodgkin's lymphoma. PMID: 24530479
5. Overall survival was significantly longer in multiple myeloma patients with KRT81 rs3660 C/C variant PMID: 22539802
6. KRT81 has emerged as a promising immunohistochemical marker for the identification of squamous cell lung carcinoma PMID: 21799879
7. EBV-dependent upregulation of hHb1-DeltaN in gastric carcinoma cell lines PMID: 14520698
8. The KRTHB1 expression uniformly occurred in the midcortex region. PMID: 15797458
9. Transfected p65 induces transcriptional activation of Hb1. PMID: 18021261
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相關(guān)疾病：

Monilethrix (MNLIX)
蛋白家族：

Intermediate filament family
組織特異性：

Abundantly expressed in the differentiating cortex of growing (anagen) hair. Expression is restricted to the keratinocytes of the hair cortex and is absent from inner root sheath and medulla. Expressed in malignant lymph node tissue in breast carcinoma ti
數(shù)據(jù)庫鏈接：

HGNC: 6458

OMIM: 158000

KEGG: hsa:3887

STRING: 9606.ENSP00000369349

UniGene: Hs.658118