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  4. Recombinant Human Keratin, type I cytoskeletal 17 (KRT17)

Recombinant Human Keratin, type I cytoskeletal 17 (KRT17)

  • 中文名稱：
    Recombinant Human Keratin, type I cytoskeletal 17 (KRT17)
  • 貨號(hào)：
    CSB-EP012516HU
  • 規(guī)格：
    ￥1836
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length
  • 來源：
    E.coli
  • 分子量：
    55.0 kDa
  • 表達(dá)區(qū)域：
    1-432aa
  • 氨基酸序列
    MTTSIRQFTSSSSIKGSSGLGGGSSRTSCRLSGGLGAGSCRLGSAGGLGSTLGGSSYSSCYSFGSGGGYGSSFGGVDGLLAGGEKATMQNLNDRLASYLDKVRALEEANTELEVKIRDWYQRQAPGPARDYSQYYRTIEELQNKILTATVDNANILLQIDNARLAADDFRTKFETEQALRLSVEADINGLRRVLDELTLARADLEMQIENLKEELAYLKKNHEEEMNALRGQVGGEINVEMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEDWFFSKTEELNREVATNSELVQSGKSEISELRRTMQALEIELQSQLSMKASLEGNLAETENRYCVQLSQIQGLIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHLTQYKKEPVTTRQVRTIVEEVQDGKVISSREQVHQTTR
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    C-terminal 6xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.
  • 基因功能參考文獻(xiàn)：
    1. A report of a recurrent mutation in the KRT17 gene found in a family with severe SM, which provides further evidence that some factors such as modifiers, androgenic stimulation and/or environment influence the phenotypes, and other genetic or proteomic conditions might also influence the final manifestations of the disease. PMID: 29218738
    2. High CK17 expression is associated with lymph node metastasis in oral squamous cell carcinoma. PMID: 30066921
    3. High expression of KRT17 is frequent in Lung adenocarcinoma tissues. PMID: 29991674
    4. Narrow-band ultraviolet B irradiation could downregulate K17 expression by inhibiting the ERK1/2 and STAT3 signaling pathways. PMID: 29349514
    5. Our results highlight KRT17 as a possible biomarker in gastric cancer promoting tumor growth, motility, and invasion, and suggest that KRT17 can be a valuable molecular target for development of anti-gastric cancer-specific therapies PMID: 28299464
    6. The findings suggest that CK17, although not specific for differentiated vulvar intraepithelial neoplasia (dVIN), when combined with histologic findings, Ki-67, and p53 immunohistochemistry, can be a marker of vulvar dysplasia and serve as an adjunct in the diagnosis of dVIN. PMID: 27513074
    7. Krt17 was demonstrated to contribute to areca nut-induced oral malignancy PMID: 27432155
    8. TGFbeta/SMAD/miR-486-3p signaling axis in keratinocytes regulated K17 expression and cell proliferation. We conclude that the loss of miR-486-3p in psoriatic epidermis leads to K17 protein overexpression and contributes to the pathogenesis of psoriasis. PMID: 28642156
    9. KRT17 promotes tumor cell growth, at least partially, through its anti-apoptotic effect as a result of the KRT17 overexpression by GLIs in oral squamous cell carcinoma (OSCC).. PMID: 28342001
    10. TGF-beta1-induced CK17 enhances cancer stem cell-like properties rather than epithelial-mesenchymal transition in promoting cervical cancer metastasis via the ERK1/2-MZF1 signaling pathway. PMID: 28703907
    11. K17 is highly expressed in most cases of both invasive adenocarcinoma and in AIS and is a powerful, negative prognostic marker for patient survival. PMID: 28821199
    12. the data suggest that the loss of Krt17 may foster an overall protective environment for lesion-prone cervical tissue. PMID: 27065324
    13. High KR17 expression is associated with oral cancer. PMID: 27512993
    14. K17 is expressed in a subset of triple-negative breast cancers, and is a marker of poor prognosis in patients with advanced stage and ER(-)/HER2(-) breast cancer. PMID: 27816721
    15. MiR-138 may regulate K17 protein expression to affect cell proliferation and apoptosis by targeting hTERT gene in keratinocytes from psoriatic vulgaris patients. PMID: 27936398
    16. The pattern of CK17 expression is a highly sensitive marker for distinguishing cutaneous lymphadenoma from basal cell carcinoma in small samples. PMID: 26968559
    17. Cytokeratin 17 immunoexpression might have a role in evaluating surgical borders in some cases of actinic keratosis and Bowen disease. PMID: 26740287
    18. Steatocystoma multiplex is associated with the R94C mutation in the KRTl7 gene, and is reported in a Chinese pedigree. PMID: 26165312
    19. These findings suggest that CK17 is involved in the development and metastasis of papillary thyroid carcinoma PMID: 26191283
    20. Case Report: polycystic kidney disease with steatocystoma multiplex. PKD1 mutations disrupt keratin 17 polymerization. PMID: 25111597
    21. our findings establish that K17 functions specially among keratins as an oncoprotein by controlling the ability of p27(KIP1) to influence cervical cancer pathogenesis. PMID: 26109559
    22. Data indicate that autoimmune regulator Aire mRNA transcripts are regulated in a keratin 17 (K17) dependent manner in skin tumor keratinocytes. PMID: 26168014
    23. We conclude that K17 expression promotes oral squamous cell carcinoma cell growth and cell size but does not affect cell migration PMID: 25736868
    24. Report overexpression of keratin 17 in premalignant and malignant squamous lesions of the cervix. PMID: 24051697
    25. novel heterozygous mutation, p.L91P (c.272T>C) in the helix initiation motif, associated with pachyonychia congenita type 2 PMID: 23855588
    26. Peripheral or diffuse staining for CK17 is a useful marker of invasion in anal squamous neoplastic lesions. PMID: 24335642
    27. KRT17 is necessary for oncogenic transformation in Ewing sarcoma and accounts for much of the GLI1-mediated transformation function but via a mechanism independent of AKT signaling. PMID: 24043308
    28. Overexpression of keratin 17 is associated with epithelial ovarian cancer. PMID: 23430585
    29. a novel mutation in a Chinese pedigree of pachyonychia congenita type 2 with typical clinical presentations and an autosomal dominant inheritance pattern PMID: 23278621
    30. We identified a known mutation in the KRT17 gene in a family with steatocystoma PMID: 22639854
    31. Keratin-17 expression is correlated with tumor progression in gastric adenocarcinoma and may serve as a biomarker for poor prognosis. PMID: 22695933
    32. IL-22 up-regulates K17 expression in keratinocytes in a dose-dependent manner through STAT3- and ERK1/2-dependent mechanisms. PMID: 22808266
    33. Keratin 17 is a therapeutic target for the treatment of psoriasis [review] PMID: 22795618
    34. We observed a higher likelihood of oral leukokeratosis in individuals harboring KRT6A mutations, and a strong association of natal teeth and cysts in carriers of a KRT17 mutation. PMID: 22264670
    35. Data indicate that cytokeratin 17 (CK17) expression could be associated with the differentiation and the malignancy of oral squamous cell carcinoma (OSCC). PMID: 22466643
    36. A report on homozygosity for dominant missense mutations in keratin 17 that modify the pachyonychia congenita phenotype. PMID: 22336949
    37. Both moesin and KRT17 demonstrated a tendency of increased expression as pT stage advanced. PMID: 22076435
    38. a novel interaction involving K17 and AnxA2 and identify AnxA2 as a potential regulator of keratin filaments. PMID: 22235123
    39. Type I keratin 17 protein is phosphorylated on serine 44 by p90 ribosomal protein S6 kinase 1 (RSK1) in a growth- and stress-dependent fashion PMID: 22006917
    40. The data suggested that IL-17A can upregulate keratin-17 expression in keratinocytes in a dose-dependent manner through STAT1- and STAT3-dependent mechanisms. PMID: 21796151
    41. AIRE expression in HaCaT epidermal keratinocytes, as well as its interaction with K17, was confirmed. PMID: 21356351
    42. KRT17 is upregulated in gastric adenocarcinoma and is associated with tumor progression. PMID: 21443102
    43. mutation of KRT17 may play a major role in the pathogenesis of this pedigree with pachyonychia congenita type 2. PMID: 21287500
    44. Overexpression of KRT17 is associated with basal-like phenotype in breast cancer. PMID: 19882246
    45. CK17 expression is significantly higher in thyroid papillary carcinoma than benign thyroid tissue; and this characteristic can have important diagnostic value. PMID: 14761598
    46. Mutation in second half of 1A domain of K17 might delay onset of clinical phenotype. PMID: 15102078
    47. Epitopes S1 (118-132), S2 (169-183), S4 (323-337) and S4 (348-362) are immunodominant DR B1-restricted T cell epitopes for psoriasis. S1 (118-132) contains the ALEEAN sequence. Others with different amino acid sequence have not been reported before. PMID: 15795121
    48. KRT 17 seemed to be the most accurate marker for the diagnosis of micrometastases of a size >450 mum. PMID: 16638858
    49. findings showed that out of all cytokeratins, CK17 was up-regulated strongest in oral squamous cell carcinoma compared to normal samples, and over-expression was most significantly associated with diagnosis PMID: 17786476
    50. The mutation p.M88K is in the helix initiation motif (HIM) of KRT17, where 13 of the reported 14 mutations of KRT17 in PC-2 have been mapped, and the residue M88 of the HIM is also a mutation hotspot of other keratin disorders (http://www.interfil.org/). PMID: 18547302

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  • 相關(guān)疾病：
    Pachyonychia congenita 2 (PC2); Steatocystoma multiplex (SM)
  • 亞細(xì)胞定位：
    Cytoplasm.
  • 蛋白家族：
    Intermediate filament family
  • 組織特異性：
    Expressed in the outer root sheath and medulla region of hair follicle specifically from eyebrow and beard, digital pulp, nail matrix and nail bed epithelium, mucosal stratified squamous epithelia and in basal cells of oral epithelium, palmoplantar epider
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6427

    OMIM: 148069

    KEGG: hsa:3872

    STRING: 9606.ENSP00000308452

    UniGene: Hs.2785



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