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  4. Recombinant Human Katanin p60 ATPase-containing subunit A-like 1 (KATNAL1)

Recombinant Human Katanin p60 ATPase-containing subunit A-like 1 (KATNAL1)

  • 中文名稱：
    人KATNAL1重組蛋白
  • 貨號：
    CSB-YP863134HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人KATNAL1重組蛋白
  • 貨號：
    CSB-EP863134HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人KATNAL1重組蛋白
  • 貨號：
    CSB-EP863134HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人KATNAL1重組蛋白
  • 貨號：
    CSB-BP863134HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人KATNAL1重組蛋白
  • 貨號：
    CSB-MP863134HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    KATNAL1
  • Uniprot No.：
  • 別名：
    Katanin p60 ATPase containing subunit A like 1; Katanin p60 ATPase-containing subunit A-like 1; Katanin p60 subunit A like 1; Katanin p60 subunit A-like 1; KATL1_HUMAN; KATNAL1; MGC2599; OTTHUMP00000018194; OTTHUMP00000042415; OTTHUMP00000061637; p60 katanin like 1; p60 katanin-like 1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-490
  • 氨基酸序列
    MNLAEICDNA KKGREYALLG NYDSSMVYYQ GVMQQIQRHC QSVRDPAIKG KWQQVRQELL EEYEQVKSIV STLESFKIDK PPDFPVSCQD EPFRDPAVWP PPVPAEHRAP PQIRRPNREV RPLRKEMAGV GARGPVGRAH PISKSEKPST SRDKDYRARG RDDKGRKNMQ DGASDGEMPK FDGAGYDKDL VEALERDIVS RNPSIHWDDI ADLEEAKKLL REAVVLPMWM PDFFKGIRRP WKGVLMVGPP GTGKTMLAKA VATECGTTFF NVSSSTLTSK YRGESEKLVR LLFEMARFYA PTTIFIDEID SICSRRGTSD EHEASRRVKS ELLIQMDGVG GALENDDPSK MVMVLAATNF PWDIDEALRR RLEKRIYIPL PTAKGRAELL KINLREVELD PDIQLEDIAE KIEGYSGADI TNVCRDASLM AMRRRINGLS PEEIRALSKE ELQMPVTKGD FELALKKIAK SVSAADLEKY EKWMVEFGSA
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays. Has microtubule-severing activity in vitro.
  • 基因功能參考文獻：
    1. microdeletion 13q12.3 represents a novel clinically recognizable condition and that the microtubule severing gene KATNAL1 and the chromatin-associated gene HMGB1 are candidate genes for intellectual disability inherited in an autosomal dominant pattern. PMID: 24664804
    2. KATNAL1 gene sequence variants are not associated with azoospermia. PMID: 24913027
    3. KL1-mediated microtubule severing is utilized to generate microtubule seeds within the poles and loss of this activity alters the normal balance of motor-generated forces that determine spindle length. PMID: 20519956
  • 亞細胞定位：
    Cytoplasm, cytoskeleton. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, spindle.
  • 蛋白家族：
    AAA ATPase family, Katanin p60 subunit A1 subfamily, A-like 1 sub-subfamily
  • 組織特異性：
    Expressed in testis, restricted to Sertoli cells (at protein level).
  • 數據庫鏈接：

    HGNC: 28361

    OMIM: 614764

    KEGG: hsa:84056

    STRING: 9606.ENSP00000369989

    UniGene: Hs.243596



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