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  4. Recombinant Human KH domain-containing, RNA-binding, signal transduction-associated protein 3 (KHDRBS3)

Recombinant Human KH domain-containing, RNA-binding, signal transduction-associated protein 3 (KHDRBS3)

  • 中文名稱：
    人KHDRBS3重組蛋白
  • 貨號：
    CSB-YP012156HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人KHDRBS3重組蛋白
  • 貨號：
    CSB-EP012156HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人KHDRBS3重組蛋白
  • 貨號：
    CSB-EP012156HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人KHDRBS3重組蛋白
  • 貨號：
    CSB-BP012156HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人KHDRBS3重組蛋白
  • 貨號：
    CSB-MP012156HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    KHDRBS3
  • Uniprot No.：
  • 別名：
    Etle; etoile; KH domain containing RNA binding signal transduction associated 3; KH domain containing RNA binding signal transduction associated protein 3; KH domain-containing; KHDR3_HUMAN; Khdrbs3; RNA binding protein T Star ; RNA-binding; RNA-binding protein T-Star; SALP; Sam68 like mammalian protein 2; Sam68 like phosphotyrosine protein; Sam68 like phosphotyrosine protein T STAR; Sam68-like mammalian protein 2; Sam68-like phosphotyrosine protein; signal transduction-associated protein 3; SLM 2; SLM-2; SLM2; T STAR; TSTAR
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-346
  • 氨基酸序列
    MEEKYLPELM AEKDSLDPSF THALRLVNQE IEKFQKGEGK DEEKYIDVVI NKNMKLGQKV LIPVKQFPKF NFVGKLLGPR GNSLKRLQEE TLTKMSILGK GSMRDKAKEE ELRKSGEAKY FHLNDDLHVL IEVFAPPAEA YARMGHALEE IKKFLIPDYN DEIRQAQLQE LTYLNGGSEN ADVPVVRGKP TLRTRGVPAP AITRGRGGVT ARPVGVVVPR GTPTPRGVLS TRGPVSRGRG LLTPRARGVP PTGYRPPPPP PTQETYGEYD YDDGYGTAYD EQSYDSYDNS YSTPAQSGAD YYDYGHGLSE ETYDSYGQEE WTNSRHKAPS ARTAKGVYRD QPYGRY
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro. Binds optimally to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). RNA-binding abilities are down-regulated by tyrosine kinase PTK6. Involved in splice site selection of vascular endothelial growth factor. In vitro regulates CD44 alternative splicing by direct binding to purine-rich exonic enhancer. Can regulate alternative splicing of neurexins NRXN1-3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners such as neuroligins and LRRTM family members. Targeted, cell-type specific splicing regulation of NRXN1 at AS4 is involved in neuronal glutamatergic synapse function and plasticity. May regulate expression of KHDRBS2/SLIM-1 in defined brain neuron populations by modifying its alternative splicing. Can bind FABP9 mRNA. May play a role as a negative regulator of cell growth. Inhibits cell proliferation.; (Microbial infection) Involved in post-transcriptional regulation of HIV-1 gene expression.
  • 基因功能參考文獻：
    1. Down-regulating the KHDRBS3 gene can cause G0/G1 phase arrest and inhibit cell proliferation in CAOV-3 cells. PMID: 28871947
    2. Sam68 and T-STAR could regulate alternative splicing of some pre-mRNAs by bringing two distant UAA motifs into proximity and looping out regions of the pre-mRNA. PMID: 26758068
    3. Nuclear T-STAR protein expression correlates with HER2 status, hormone receptor negativity and prolonged recurrence free survival in primary breast cancer and decreased cancer cell growth in vitro. PMID: 23923007
    4. SerpinB5 interacts with KHDRBS3 and FBXO32, and KHDRBS3 can interact with FBXO32 mRNA. PMID: 21725612
    5. SLM-2-dependent VEGF splicing indicates the importance of mRNA splice site selection for glomerular filtration barrier function. PMID: 15901763
    6. The T-STAR gene may participate in regulation of telomerase activity in human colon cancer HCT-116 cells in a parallel fashion. PMID: 16810759
    7. data implicate hsa-miR-30b, hsa-miR-30d and KHDRBS3 as putative oncogenic target(s) of a novel recurrent medulloblastoma amplicon at 8q24.22-q24.23 PMID: 19584924

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  • 亞細胞定位：
    Nucleus. Note=Localized in a compartment adjacent to the nucleolus, but distinct from the peri-nucleolar one.
  • 蛋白家族：
    KHDRBS family
  • 組織特異性：
    Ubiquitous with higher expression in testis, skeletal muscle and brain. Expressed in the kidney only in podocytes, the glomerular epithelial cells of the kidney. Strongly expressed after meiosis.
  • 數據庫鏈接：

    HGNC: 18117

    OMIM: 610421

    KEGG: hsa:10656

    STRING: 9606.ENSP00000348108

    UniGene: Hs.444558



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