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  4. Recombinant Human Intersectin-2 (ITSN2), partial

Recombinant Human Intersectin-2 (ITSN2), partial

  • 中文名稱：
    人ITSN2重組蛋白
  • 貨號：
    CSB-YP873709HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人ITSN2重組蛋白
  • 貨號：
    CSB-EP873709HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人ITSN2重組蛋白
  • 貨號：
    CSB-EP873709HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人ITSN2重組蛋白
  • 貨號：
    CSB-BP873709HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人ITSN2重組蛋白
  • 貨號：
    CSB-MP873709HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ITSN2
  • Uniprot No.：
  • 別名：
    ITSN2; KIAA1256; SH3D1B; SWAP; Intersectin-2; SH3 domain-containing protein 1B; SH3P18; SH3P18-like WASP-associated protein
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes.
  • 基因功能參考文獻：
    1. These findings provide the basis for further functional investigations of the ITSN/CR16 complex that may play an important role in actin remodeling and cellular invasion. PMID: 28161632
    2. ITSN2L interacts with RABEP1 and stimulates its degradation in regulation of endocytosis. PMID: 26633357
    3. The ITSN2 interacts with Eps8 and stimulates the degradation of Eps8 proteins. PMID: 22449706
    4. ITSN1 and ITSN2 bind similar proline-rich ligands but are differentially recognized by SH2 domain-containing proteins. PMID: 23936226
    5. The sequence and structural alignment of ITSN-2L C2 domain with other members of C2 domain protein family indicate its vital cellular roles in membrane trafficking, the generation of lipid-second messengers and activation of GTPases. Moreover, our data show the possible roles of ITSN-2L C2 domain in regulating the activity of Cdc42. PMID: 23274495
    6. These results highlight a role of Numb for dendritic spine development and synaptic functions with intersectin and EphB2. PMID: 16394100
    7. ITSN2C may be specifically expressed in neurons hinting to a physiologic role in neuronal cell function. PMID: 17390067
    8. We show that the PPLP motif of K15 protein selectively binds the SH3-C domain of an endocytic adaptor protein, Intersectin 2 (ITSN2). PMID: 17696407
    9. ITSN-2L, a guanine nucleotide exchange factor for Cdc42, regulates different steps of caveola endocytosis in ECs by controlling the temporal and spatial actin polymerization and remodeling sub-adjacent to the plasma membrane. PMID: 19622753

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  • 亞細胞定位：
    Cytoplasm.
  • 組織特異性：
    Expressed in melanocytes. Ubiquitous. Isoform 1 is primarily expressed in adult heart and liver.
  • 數據庫鏈接：

    HGNC: 6184

    OMIM: 604464

    KEGG: hsa:50618

    STRING: 9606.ENSP00000347244

    UniGene: Hs.432562



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