在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Interleukin-27 receptor subunit alpha (IL27RA), partial

Recombinant Human Interleukin-27 receptor subunit alpha (IL27RA), partial

  • 中文名稱：
    人IL27RA重組蛋白
  • 貨號：
    CSB-YP761488HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人IL27RA重組蛋白
  • 貨號：
    CSB-EP761488HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人IL27RA重組蛋白
  • 貨號：
    CSB-EP761488HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人IL27RA重組蛋白
  • 貨號：
    CSB-BP761488HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人IL27RA重組蛋白
  • 貨號：
    CSB-MP761488HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Class I cytokine receptor; CRL1; Cytokine receptor-like 1; I27RA_HUMAN; IL-27 receptor subunit alpha; IL-27R subunit alpha; IL-27R-alpha; IL-27RA; IL27R alpha; IL27R; Il27ra; Interleukin 27 receptor alpha chain precursor; Interleukin 27 receptor; Interleukin-27 receptor subunit alpha; Protein CRL1; T cell cytokine receptor type 1; TCCR; Type 1 T cell cytokine receptor; Type I T-cell cytokine receptor; WSX-1; WSX1; ZcytoR1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Receptor for IL27. Requires IL6ST/GP130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL6ST/GP130 and CNTFR. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms.
  • 基因功能參考文獻：
    1. this study found elevated expression of IL-27 in human peripheral serum and elevated expression of its specific receptor (wsx-1) on fetal membranes in cases of preterm birth PMID: 28756371
    2. These results identify IL-27 and its specific receptor IL27RA as a critical immune axis for the antiviral immune response and as robust correlates of viral load and proviral reservoir size in mononuclear leukocytes in HIV infection. PMID: 28592538
    3. Findings demonstrated that IL-27 and IL-27R were elevated in multiple sclerosis lesions and that local IL-27 can modulate immune properties of astrocytes and infiltrating immune cells PMID: 26649511
    4. The significant expression of IL-27 in TB and the negative influence of IL-27R on T cell function demonstrate the pathway by which this cytokine/receptor pair is detrimental in TB. PMID: 26282876
    5. natural sIL-27Ralpha binds rIL-27, inhibits IL-27 binding to its cell surface receptor, and is a potent inhibitor of IL-27 signaling, as shown by its ability to specifically block IL-27-mediated STAT activation, at low molar excess over IL-27. PMID: 24771852
    6. Aberrant hypermethylation and reduced expression of IL27RA is associated with myelodysplastic syndromes. PMID: 22936014
    7. TCCR/WSX-1 is closely associated with angiogenesis and could serve as a novel therapeutic target in patients with age-related macular degeneration. PMID: 22312192
    8. Mutations in the transmembrane and juxtamembrane domains enhance IL27R transforming activity. PMID: 21631431
    9. WSX-1 is essential for transcriptional activation of STAT1 and for augmenting the induction of T-bet expression during initiation of Th1 cell differentiation. PMID: 12734330
    10. WSX-1 together with the cytokine receptor gp130 constitutes a functional signal-transducing receptor for IL-27. PMID: 14764690
    11. IL-27R possesses hematopoietic cell-transforming properties PMID: 18003935
    12. These results indicate that humanin protects neurons by binding to a complex or complexes involving CNTFR/WSX-1/gp130. PMID: 19386761
    13. Results reveal an interleukin 27-independent function of WSX1 sensitizing natural killer cell-mediated antitumor surveillance. PMID: 19549909

    顯示更多

    收起更多

  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Type I cytokine receptor family, Type 2 subfamily
  • 組織特異性：
    Highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes. Weakly expressed in other tissues examined including heart, brain, fetal and adult lung, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, s
  • 數據庫鏈接：

    HGNC: 17290

    OMIM: 605350

    KEGG: hsa:9466

    STRING: 9606.ENSP00000263379

    UniGene: Hs.132781



主站蜘蛛池模板： 亚洲六月丁香六月婷婷| 国产亚洲精品第一综合不卡| 中国少妇初尝黑人巨高清| 天天影视性色香欲综合网| 黑人强辱丰满的人妻熟女| 女人张开腿让男桶喷水高潮| 国产精品欧美久久久久无广告| 疯狂迎合进入强壮公的视频| 午夜伦yy44880影院| 久久精品国产男包| 亚洲精品亚洲人成在线下载| 无码一区二区| 国产精品亚洲综合一区在线观看| 国产丝袜在线精品丝袜| 丰满白嫩人妻中出无码| 大陆熟妇丰满多毛xxxx| 日本熟日本熟妇在线视频| 天码欧美日本一道免费| 后进式无遮挡啪啪摇乳动态图| 2021年精品国产福利在线| 综合五月激情二区视频| 久久久久人妻精品一区蜜桃| 奇米综合四色77777久久| 综合色就爱涩涩涩综合婷婷| 中文字幕高清免费日韩视频在线| 18禁成年免费无码国产| 香蕉啪视频在线观看视频久| 亚洲日韩中文字幕在线播放 | а√天堂资源官网在线资源| 国产天美传媒性色av出轨| 精品卡1卡2卡三卡免费网站| 四虎免费大片aⅴ入口| 亚洲国产欧美在线成人| 亚洲综合天堂一区二区三区| 国产天堂亚洲国产碰碰| 99视频在线精品免费观看6| 99热精品国自产拍天天拍| 色五月丁香六月欧美综合| 亚洲精品成人无限看| 国产色青青视频在线观看撒| 国产日产欧产精品品不卡|