在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Interleukin-20 (IL20)

  • 中文名稱:
    人IL20重組蛋白
  • 貨號:
    CSB-YP873699HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人IL20重組蛋白
  • 貨號:
    CSB-EP873699HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人IL20重組蛋白
  • 貨號:
    CSB-EP873699HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人IL20重組蛋白
  • 貨號:
    CSB-BP873699HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人IL20重組蛋白
  • 貨號:
    CSB-MP873699HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    Cytokine Zcyto10; Four alpha helix cytokine; IL-20; IL10D; IL20; IL20_HUMAN; Interleukin 20; Interleukin-20; MGC96907; UNQ852/PRO1801; ZCYTO10
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    25-176
  • 氨基酸序列
    LKTLNL GSCVIATNLQ EIRNGFSEIR GSVQAKDGNI DIRILRRTES LQDTKPANRC CLLRHLLRLY LDRVFKNYQT PDHYTLRKIS SLANSFLTIK KDLRLCHAHM TCHCGEEAMK KYSQILSHFE KLEPQAAVVK ALGELDILLQ WMEETE
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act through STAT3.
  • 基因功能參考文獻:
    1. Authors demonstrated that ER(alpha), GATA3 and FOXA1 form a transcriptional complex with Ell3 to regulate IL-20 expression in ER(+) breast cancer cells. FOXA1 represses IL-20 expression, whereas GATA3 and ER(alpha) activate it. PMID: 28514748
    2. The authors results indicate that genetic variants of the immunomodulatory IL10 and IL20 genes may offer a protective effect in Europeans from Russia. PMID: 28150860
    3. data showed that IL-20 is independently associated with rheumatoid arthritis disease activity and may be triggered by TLR ligands at local sites of inflammation PMID: 28662439
    4. IL-20 is a multifunctional cytokine with potent inflammatory, angiogenic, chemoattractive, and osteoclastogenic effects, and is involved in the many phases of rheumatic arthritis progression. [Review] PMID: 26297177
    5. Data suggest that HGF, IL-20, and IL-22 in the serum and bronchoalveolar lavage fluid (BALF) of non-small cell lung cancer (NSCLC) patients before chemotherapy may be a prognostic of cancer progression. PMID: 27573644
    6. The current study provides evidence that IL-20 directly targets and inhibits key inflammatory functions of neutrophils during infection with S. aureus. PMID: 28424238
    7. Results found that IL-20 is more specifically associated with ER-positive breast cancer and is epigenetically regulated by estrogen via the specific recruitment of KMT2B by ERalpha. PMID: 27806114
    8. Coincident diabetes mellitus type 2 in either pulmonary or latent tuberculosis is characterized by decreased production of the IL-20 subfamily of cytokines. PMID: 26354610
    9. IL-20 serum levels were increased in patients with active multiple myeloma compared to both healthy controls and responders to bortezomib-based treatment.IL-20 participate actively in the pathophysiology of multiple myeloma progression. PMID: 25631632
    10. Overexpression of IL-20 was detected in the airway epithelium collected from patients with asthma. PMID: 25028099
    11. IL-20 may play a patho-physiologic role in the Th2 immune response in human asthma and may be a potential biomarker of asthma severity. PMID: 25543042
    12. IL-20 is produced by keratinocytes, released into the epidermis and then possibly taken up by papillary mononuclear cells PMID: 24628979
    13. Decreased interleukin-20 expression in scleroderma skin contributes to cutaneous fibrosis. PMID: 24470401
    14. We observed that IL-20 which is an IL-10 group angiogenesis indicator was suppressed in systemic sclerosis, suggesting abnormal angiogenesis. PMID: 23812620
    15. This study demonstrates that rs1713239 and infection may have potential synergetic effect on modulating the transcriptional activity of IL-20. PMID: 23892591
    16. The mRNA levels of p40, IL-20 and IL-21 at baseline may serve as potential predictors of treatment response to ustekinumab treatment in psoriasis. PMID: 22930279
    17. IL-10-- and IL-20--expressing epithelial and inflammatory cells are increased in patients with ulcerative colitis. PMID: 23207823
    18. the GG genotypes of the IL-20 polymorphisms (rs2981573 and rs2232360) might have an important role in the development of UC in the Mexican population. PMID: 23183096
    19. A blood test for discrimination of patients with acute cellular rejection from transplanted kidney is based on simultaneous quantification of three analytes: IL-1 receptor antagonist, IL-20 and soluble CD40 ligand. PMID: 22948742
    20. Interleukin-20 promotes migration of bladder cancer cells through extracellular signal-regulated kinase (ERK)-mediated MMP-9 protein expression leading to nuclear factor (NF-kappaB) activation by inducing the up-regulation of p21(WAF1) protein expression PMID: 23271730
    21. Elevated expression of inflammatory cytokines (IL-5, IL-20, and IL-28A) is associated with bladder cancer development. PMID: 22962576
    22. crystallographic asymmetric unit contains one IL-20-IL-20R1-IL-20R2 complex, corresponding to a solvent content of approximately 54% PMID: 22232181
    23. IL-20 & its receptors were epigenetically regulated through histone post-translational modifications and DNA CpG residue methylation. Also, treatment with recombinant IL-20 resulted in decreased expression of the VEGF family members at the mRNA level. PMID: 21565488
    24. The G allele of the IL-20 -1723C to G polymorphism may contribute to a genetic susceptibility to psoriasis in the Chinese Han population, particularly in patients with psoriasis triggered or exacerbated by an upper respiratory tract infection. PMID: 21109726
    25. in premenopausal obese women, interleukin-20 levels are higher than matched normal weight control women, are associated with body weight and waist-hip ratio, and are reduced by weight loss PMID: 19481430
    26. Essentially identical phenotypes in transgenic mouse models for IL-20, IL-22, and IL-24 suggest that the three related cytokines play a redundant role in keratinocyte differentiation and proliferation. PMID: 20061404
    27. human IL-20 enhanced colony formation by CD34+ multipotential progenitors, buthad no effect on erythroid, granulocyte-macrophage, or megakaryocyte progenitors. PMID: 12855566
    28. IL-19 and IL-20 are synthesized by a distinct population of keratinocytes. PMID: 14675174
    29. Altogether our findings revealed that IL-20 is a negative modulator of COX-2/PGE(2) and inhibits angiogenesis. PMID: 15950941
    30. IL-20 is a pleiotropic cytokine and promotes angiogenesis. PMID: 16511554
    31. IL-20 may influence inflammation through IFN-like effects. These data indicate that IL-20 may be an important effector cytokine in psoriasis, and that its inhibition may represent a potential therapeutic target. PMID: 16645593
    32. Ultraviolet light with photosensitizing agents had little effect or decreased epithelial keratinocyte il-20 levels. PMID: 16709143
    33. IL-20 is a proatherogenic cytokine that contributes to the progression of atherosclerosis. PMID: 16778121
    34. IL-20 protein is expressed in 30 non-neoplastic tissue types and five major cell types: epithelial cells, myoepithelial cells, endothelial cells, macrophages, skeletal muscle cells, and several types of tumor cells. PMID: 16908179
    35. p38 mitogen-activated protein kinase (MAPK) as well as inhibitory kappaB kinase-NF-kappaB signaling pathways are crucial for IL-20 expression in keratinocytes PMID: 17255956
    36. Review. The role of IL-20 in the pathogenesis of inflammatory diseases is reviewed. PMID: 17465720
    37. Activation of toll-like receptors 2 and 3 show keratinocytes in the simultaneous presence of IL-20 and IL-29. PMID: 18281438
    38. results suggest that IL10 and IL20 gene variants influence hepatitis B virus infection outcome PMID: 18479293
    39. IL-20 plays an important role in the pathogenesis of disc herniation. PMID: 18758357
    40. novel effects of IL-20 on mesangial cells and its association with lupus nephritis. PMID: 18771958
    41. IL-20 was responsive to hypoxia in vitro and in the ischemic stroke model and that up-regulation of IL-20 in the ischemic brain may contribute to brain injury PMID: 19342680
    42. Data show that in lesional skin of psoriasis patients, highly elevated IL-20 levels strongly correlated with IL-22, and to a lesser extent, with IL-17A and TNF-alpha. PMID: 19830738

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    IL-10 family
  • 組織特異性:
    Expressed in most tissues and five major cell types: epithelial cells (primarily skin, buccal mucosa, tongue, nasal mucosa, lung, ureter, breast, prostate, fallopian tube, and adrenal gland), myoepithelial cells (mainly prostate), endothelial cells (mainl
  • 數據庫鏈接:

    HGNC: 6002

    OMIM: 605619

    KEGG: hsa:50604

    STRING: 9606.ENSP00000356063

    UniGene: Hs.272373



主站蜘蛛池模板: 一二三四视频社区在线| 18禁止看的免费污网站| 久久国产劲爆∧v内射| 风韵犹存丰满大屁股熟妇| 久久精品国产一区二区免费| 性饥渴少妇av无码毛片| 亚洲狠狠婷婷综合久久| 少妇无套内谢久久久久| 亚洲欧美日韩在线资源观看| 国产精品福利一区二区久久| 亚洲国产中文在线二区三区免 | 精品久久久久国产免费| 少妇人妻大乳在线视频不卡| 熟妇的奶头又大又长奶水视频| 亚洲色欲色欱www在线| 国产成人综合欧美精品久久| 久久视频在线视频精品| 大香伊人久久精品一区二区| 国产精品99久久精品爆乳 | 亚洲成av人综合在线观看| 无修无码h里番在线播放网站 | 久久露脸国产精品| 国产偷国产偷亚洲清高app| 久激情内射婷内射蜜桃| 久久精品国产99久久6动漫| 国产多人群p刺激交换视频| 欧美另类videossexo高潮| 亚洲成av人片在一线观看| 久久久久 亚洲 无码 av 专区| 国产国拍精品av在线观看按摩| 久久久久久自慰出白浆| 国产成人无码va在线观看| 精品多人p群无码| 国产一精品一av一免费| 国产av人人夜夜澡人人爽| 精品一卡2卡三卡4卡乱码精品视频 | 亚洲愉拍99热成人精品| 无码欧美黑人xxx一区二区三区| 男女一边摸一边做爽爽的免费阅读| 欧美黑人又粗又大又爽免费| 中文字幕无码毛片免费看|