在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Intercellular adhesion molecule 4 (ICAM4), partial

Recombinant Human Intercellular adhesion molecule 4 (ICAM4), partial

  • 中文名稱：
    人ICAM4重組蛋白
  • 貨號：
    CSB-YP619892HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人ICAM4重組蛋白
  • 貨號：
    CSB-EP619892HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人ICAM4重組蛋白
  • 貨號：
    CSB-EP619892HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人ICAM4重組蛋白
  • 貨號：
    CSB-BP619892HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人ICAM4重組蛋白
  • 貨號：
    CSB-MP619892HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ICAM4
  • Uniprot No.：
  • 別名：
    CD242; CD242 antigen ; ICAM-4; Icam4; ICAM4_HUMAN; Intercellular adhesion molecule 4; Landsteiner Wiener blood group glycoprotein; Landsteiner-Wiener blood group glycoprotein; LW; LW blood group protein
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins.
  • 基因功能參考文獻：
    1. the effect of modulation of the cAMP-PKA-dependent pathway on ICAM-4 receptor activation PMID: 28076805
    2. Cytometry analysis evidenced a specific expression profile on reticulocytes of SCA infants, with notably an increased expression of the adhesion molecules Lu/BCAM, ICAM-4 and LFA-3, both in percentage of positive cells and in surface density. PMID: 26137540
    3. Seven variant ICAM4 alleles were found, distinct from the wild-type ICAM4 allele (GenBank KF712272), known as LW*05 and encoding LW(a) . PMID: 24673173
    4. Data from differentiating cultured erythroid precursor cells suggest that RhAG (Rh-associated glycoprotein) knockdown abolishes Rh blood group expression (ICAM4; RhoD [ras homolog family member D]; CD47 Rh-related antigen) in erythroid cells. PMID: 23417980
    5. Erythrocyte plasma membrane-bound ERK1/2 activation promotes ICAM-4-mediated sickle red cell adhesion to endothelium. PMID: 22147898
    6. In a transgenic mouse model of sickle cell disease ICAM-4 is implicated in abnormal adhesiveness of erythrocytes to endothelium. PMID: 20015873
    7. LWa allele occurs with incidence of 100% of donors in this study, while LWb allele has not been found in Chinese population. PMID: 18549656
    8. ICAM-4 as the first red blood cells protein ligand of platelets that may have relevant physiological significance PMID: 12477717
    9. binds to the I domains of the CD11a/CD18 and CD11b/CD18 leukocyte integrins PMID: 12694184
    10. 12 single amino-acid changes in ICAM4 affected the interaction of ICAM-4 with alpha(V) integrins PMID: 14551135
    11. LW on sickle but not on normal erythrocytes undergoes increased PKA-dependent serine phosphorylation as a result of activation. The major counter receptor for LW was identified as the alphavbeta3 integrin on ECs PMID: 15308566
    12. Different integrins bind to different but partly overlapping sites on ICAM4, and ICAM4 may accommodate multiple integrin receptors present on leukocytes, platelets and endothelial cells. PMID: 15355350
    13. Review. LW antigen contributes to RBC adhesion, thrombosis, and (in sickle cell disease) vaso-occlusion. PMID: 16564726
    14. We show that ICAM-4 functions as a ligand for the monocyte/macrophage-specific CD11c/CD18. Deletion of the individual immunoglobulin domains of ICAM-4 demonstrated that both its domains contain binding sites for CD11c/CD18. PMID: 16985175
    15. LW play potentially pathophysiological roles in sickle cell disease PMID: 17609430

    顯示更多

    收起更多

  • 亞細胞定位：
    [Isoform Long]: Cell membrane; Single-pass type I membrane protein.; [Isoform Short]: Secreted.; Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Immunoglobulin superfamily, ICAM family
  • 組織特異性：
    Erythrocytes.
  • 數據庫鏈接：

    HGNC: 5347

    OMIM: 111250

    KEGG: hsa:3386

    STRING: 9606.ENSP00000342114

    UniGene: Hs.706750



主站蜘蛛池模板： 99re6在线视频精品免费下载| 蜜桃mv在线播放免费观看视频| 精品无码人妻一区二区三区| 强奷乱码中文字幕熟女导航| 中文乱码字幕视频观看网站免费| 久久国内精品自在自线观看| 97av麻豆蜜桃一区二区| 无码国产精品一区二区免费i6 | 在线不卡日本v一区二区| 久久国产免费观看精品3| 亚洲熟妇无码av不卡在线| 亚洲精品永久在线观看| 亚洲爆乳无码专区www| 新版天堂8中文在线最新版官网| 免免费国产aaaaa片| 天天摸天天碰天天添| 国产亚洲人成在线播放| 欧美伦费免费全部午夜最新| 国产无人区码一码二码三mba| 老子午夜精品无码不卡| 亚洲mv国产mv在线mv综合试看| 东京热大乱系列无码| 久久99精品久久只有精品| 伊人蕉久中文字幕无码专区 | 亚洲无线码中文字幕在线| 无码专区久久综合久中文字幕| 国内精品久久久久伊人av| 亚洲国产欧美国产综合久久| 亚洲日韩乱码中文无码蜜桃臀网站| 伊人久久精品一区二区三区| 人妻换人妻仑乱| 日本视频免费高清一本18| 国产精品久久久久久久久鸭| 在线播放五十路熟妇| 亚洲性人人天天夜夜摸| 久久一卡二卡三卡四卡| 国产作爱视频免费播放| 人与嘼交av免费| 久久久久99精品成人片牛牛影视| 亚洲午夜精品a片一区二区app | 浪货趴办公桌～h揉秘书电影|