在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Inhibitor of Bruton tyrosine kinase (IBTK), partial

Recombinant Human Inhibitor of Bruton tyrosine kinase (IBTK), partial

  • 中文名稱：
    人IBTK重組蛋白
  • 貨號：
    CSB-YP882177HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人IBTK重組蛋白
  • 貨號：
    CSB-EP882177HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人IBTK重組蛋白
  • 貨號：
    CSB-EP882177HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人IBTK重組蛋白
  • 貨號：
    CSB-BP882177HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人IBTK重組蛋白
  • 貨號：
    CSB-MP882177HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    IBTK
  • Uniprot No.：
  • 別名：
    BTKI; IBtk; IBTK_HUMAN; inhibitor of Bruton agammaglobulinemia tyrosine kinase; Inhibitor of Bruton tyrosine kinase
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription.
  • 基因功能參考文獻：
    1. Data suggest that IBTKalpha is (a) localized in hepatocytes in endoplasmic reticulum (ER), (b) associates with specific proteins (LC3b, SEC16A, SEC31A), and (c) plays role in autophagy. Progression of nonalcoholic fatty liver disease is associated with changes in liver: (a) up-regulation of expression of IBTKalpha, (b) unfolded protein response, (c) ER stress, and (d) inhibition of autophagy. PMID: 28710282
    2. The results indicate that IBTKa differently modulates gene expression and RNA splicing in HeLa and K562 cells, demonstrating a novel biological role of this protein. PMID: 27827994
    3. CRL3(IBTK) is a novel ubiquitin ligase with regulatory roles in cellular pathways, such as the Pdcd4-dependent translation of mRNAs PMID: 25882842
    4. Depletion of IBTKalpha by short hairpin RNA reduced viability of cultured cells coincident with increased caspase 3/7 cleavage, suggesting that IBTKalpha is a key regulator in determining cell fate during the UPR. PMID: 24648495
    5. A novel pathway of Btk regulation via protein kinase C phosphorylation of IBtkgamma. PMID: 21482705
    6. three novel (Ala347fsX55, I355T, and Thr324fsX24) mutations in Bruton's tyrosine kinase in patients with X-linked agammaglobulinemia PMID: 20721470
    7. The IBTK gene encodes the proteins IBtk-alpha, beta and gamma that regulate the B cell receptor signalling through Bruton's tyrosine kinase, which promotes B cell survival and differentiation. PMID: 19782003
    8. Identification of three IBTKalpha, IBTKbeta and IBTKgamma mRNAs, whose transcription is driven by two distinct promoter regions. PMID: 18596081

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Membrane; Peripheral membrane protein. Note=Translocates to the plasma membrane upon IgM stimulation.; [Isoform 2]: Nucleus.
  • 組織特異性：
    Expressed in DeFew, HEK293T, HeLa and in Jurkat, MC3 and NB4 lymphoid cells (at protein level). Isoform 1 is the predominant isoform expressed in all examined tissues and cell lines. Highly expressed in hemopoietic tissues (fetal liver, spleen, lymph node
  • 數據庫鏈接：

    HGNC: 17853

    OMIM: 606457

    KEGG: hsa:25998

    STRING: 9606.ENSP00000305721

    UniGene: Hs.306425



主站蜘蛛池模板： 国产偷国产偷亚洲高清日韩| 护士奶头又大又软又好摸| 亚洲午夜精品久久久久久浪潮| 吸咬奶头狂揉60分钟视频| 97色偷偷色噜噜狠狠爱网站97| 免费观看在线a毛片| 久久精品国产亚洲不av麻豆| 丰满人妻中伦妇伦精品app| 妺妺窝人体色www在线小说| 国产在热线精品视频99公交| 日韩人妻少妇一区二区三区| 亚洲精品人成无码中文毛片| 日日摸天天摸爽爽狠狠97| 国产精品人成在线播放新网站| 野花社区免费观看在线www| 久久久久久午夜成人影院| 色综合av综合无码综合网站| 120秒试看无码体验区| √天堂资源在线中文8在线最新版| 搡老岳熟女国产熟妇| 2017亚洲天堂最新地址| 久久狼人大香伊蕉国产| 苍井空一区二区波多野结衣av | 欧美性猛交xxxx乱大交| 久久综合五月丁香六月丁香| 欧美xxxx狂喷水| 亚洲国产成人精品无码区四虎 | 国产精品爽爽久久久久久| 香蕉免费一区二区三区| 久久99国产精品二区| 曰韩无码二三区中文字幕| 窝窝影院午夜看片| 日韩精品真人荷官无码| 伊人99综合精品视频| 十八18禁国产精品www| 中无码人妻丰满熟妇啪啪| 99大香伊乱码一区二区| 精品香蕉一区二区三区| 无码av最新无码av专区| 亚洲中文无码mv| 欧美日韩一区二区综合|