在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Importin subunit alpha-3 (KPNA3)

  • 中文名稱:
    人KPNA3重組蛋白
  • 貨號:
    CSB-YP012485HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人KPNA3重組蛋白
  • 貨號:
    CSB-EP012485HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人KPNA3重組蛋白
  • 貨號:
    CSB-EP012485HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人KPNA3重組蛋白
  • 貨號:
    CSB-BP012485HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人KPNA3重組蛋白
  • 貨號:
    CSB-MP012485HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    KPNA3
  • Uniprot No.:
  • 別名:
    SRP1 gamma; hSRP1; IMA4_HUMAN; Importin alpha 3; Importin alpha 3 subunit; Importin alpha 4; Importin alpha Q2; Importin subunit alpha-4; IPOA4; Karyopherin alpha 3; Karyopherin alpha 3 importin alpha 4; Karyopherin alpha 3 subunit; Karyopherin subunit alpha 3; Karyopherin subunit alpha-3; KPNA 3; Kpna3; Qip2; SRP1; SRP1-gamma; SRP1gamma; SRP4
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    2-521
  • 氨基酸序列
    AENPSLENH RIKSFKNKGR DVETMRRHRN EVTVELRKNK RDEHLLKKRN VPQEESLEDS DVDADFKAQN VTLEAILQNA TSDNPVVQLS AVQAARKLLS SDRNPPIDDL IKSGILPILV KCLERDDNPS LQFEAAWALT NIASGTSAQT QAVVQSNAVP LFLRLLRSPH QNVCEQAVWA LGNIIGDGPQ CRDYVISLGV VKPLLSFISP SIPITFLRNV TWVIVNLCRN KDPPPPMETV QEILPALCVL IYHTDINILV DTVWALSYLT DGGNEQIQMV IDSGVVPFLV PLLSHQEVKV QTAALRAVGN IVTGTDEQTQ VVLNCDVLSH FPNLLSHPKE KINKEAVWFL SNITAGNQQQ VQAVIDAGLI PMIIHQLAKG DFGTQKEAAW AISNLTISGR KDQVEYLVQQ NVIPPFCNLL SVKDSQVVQV VLDGLKNILI MAGDEASTIA EIIEECGGLE KIEVLQQHEN EDIYKLAFEI IDQYFSGDDI DEDPCLIPEA TQGGTYNFDP TANLQTKEFN F
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably through ARM repeats 7-9.
  • 基因功能參考文獻:
    1. Studied the role of KPNA3 (karyopherin subunit alpha 3) in nuclear transport of ataxin-3 in spinocerebellar ataxia type 3. PMID: 29476013
    2. These results suggest that the Japanese encephalitis virus NS5 inhibits the induction of type I interferon by targeting KPNA3 and KPNA4. PMID: 28179530
    3. Karyopherin alpha 3 and karyopherin alpha 4 proteins mediate the nuclear import of methyl-CpG binding protein 2. PMID: 26245896
    4. SNP rs2273816 is significantly associated with schizophrenia, opiate dependence and alcohol dependence at the genotype and allele level PMID: 22960338
    5. The present study suggests that the KPNA3 may contribute genetically to schizophrenia in a small effect size. PMID: 15882913
    6. The present work suggests that the combination of the KPNA3 gene and the KPNB3 gene may increase a genetic risk for schizophrenia. PMID: 16644122

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    Importin alpha family
  • 組織特異性:
    Ubiquitous. Highest levels in heart and skeletal muscle.
  • 數據庫鏈接:

    HGNC: 6396

    OMIM: 601892

    KEGG: hsa:3839

    STRING: 9606.ENSP00000261667

    UniGene: Hs.527919



主站蜘蛛池模板: 亚洲国产精品成人综合色| 精品不卡一区二区| 女人爽到高潮潮喷18禁网站| 国内精品久久久久影视| 国产精品极品在线拍| 18禁美女裸体无遮挡网站| 国产激情视频一区二区三区| 人妻少妇乱子伦精品| 亚洲成成品网站源码中国有限公司 | 国产午夜成人免费看片app| 亚洲爆乳无码专区| 色与欲影视天天看综合网| 国产精品69人妻无码久久| 中文字幕精品av乱码在线| 国产卡一卡二卡三无线乱码新区| 无码少妇精品一区二区免费动态| 午夜成人影院网站18进| 日本中文一区二区三区亚洲| 无套内谢老熟女| 国产欧美日韩一区2区| 亚洲ⅴ国产v天堂a无码二区| 亚洲人成网线在线播放| 亚洲精品中文字幕一区二区三区 | 久久久亚洲欧洲日产av| 国产在线高清视频无码| 豆国产95在线 | 亚洲| 最近在线更新8中文字幕免费| yyyy11111少妇影院| 涩欲国产一区二区三区四区 | 插插无码视频大全不卡网站| 老师黑色丝袜被躁翻了av| 伊人av超碰伊人久久久| 国产无遮挡又黄又爽在线观看 | 在线成人一区二区| 人成午夜大片免费视频77777| 国产一区二区三区自产| 老司机午夜福利av无码特黄a| 人人爽人人爽人人爽人人片av| 亚洲一区波多野结衣在线| 国产专区免费资源网站| 亚洲成a人v影院色老汉影院|