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  4. Recombinant Human Hornerin (HRNR), partial

Recombinant Human Hornerin (HRNR), partial

  • 中文名稱：
    人HRNR重組蛋白
  • 貨號：
    CSB-YP010742HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人HRNR重組蛋白
  • 貨號：
    CSB-EP010742HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人HRNR重組蛋白
  • 貨號：
    CSB-EP010742HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人HRNR重組蛋白
  • 貨號：
    CSB-BP010742HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人HRNR重組蛋白
  • 貨號：
    CSB-MP010742HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    HRNR
  • Uniprot No.：
  • 別名：
    HRNR; S100A18Hornerin
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Component of the epidermal cornified cell envelopes.
  • 基因功能參考文獻：
    1. HRNR promotes tumor progression and is correlated with a poor hepatocellular carcinoma (HCC)prognosis. HRNR may contribute to HCC progression via the regulation of the AKT pathway. PMID: 30103712
    2. These results indicate that hornerin is highly expressed in pancreatic tumor endothelium and alters tumor vessel parameters through a VEGF-independent mechanism. Angiogenesis is essential for solid tumor progression. PMID: 28916756
    3. HRNR gene function is a target of FLG adaptive sweep, and the functional FLG variants that involve susceptibility to atopic dermatitis, seem to hitchhike the selective sweep on HRNR. PMID: 27678121
    4. HRNR deimination improves its cross-linking by TGases and its proteolytic processing by calpain-1. PMID: 27742573
    5. Human hornerin is a protein whose expression is changed by UVB irradiation. PMID: 23751202
    6. Analysis of the rs877776 single nucleotide polymorphism in HRNR revealed neither a significant difference in genotype distribution between patients and controls nor a significant association of the variant with any atopic dermatitis-related phenotype. PMID: 23557745
    7. Our data opens new possibilities for hornerin and its proteolytic fragments in the control of mammary cell function and breast cancer. PMID: 22727333
    8. The data demonstrate that HRNR is a component of cornified cell envelopes of human epidermis. Its reduced expression in AD may contribute to the epidermal barrier defect observed in the disease. PMID: 21282207
    9. hornerin is expressed in regenerating and psoriatic skin PMID: 15507446
    10. HRNR is expressed in healthy skin and contributes to its barrier function PMID: 19020553
    11. Observational study of gene-disease association. (HuGE Navigator) PMID: 19601998

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  • 亞細胞定位：
    Cytoplasmic granule. Note=Found in keratohyalin granules in the granular cells of the epidermis.
  • 蛋白家族：
    S100-fused protein family; S-100 family
  • 組織特異性：
    Expressed in cornified epidermis, psoriatic and regenerating skin after wounding. Found in the upper granular layer and in the entire cornified layer of epidermis.
  • 數據庫鏈接：

    HGNC: 20846

    OMIM: 616293

    KEGG: hsa:388697

    STRING: 9606.ENSP00000357791

    UniGene: Hs.490162



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