在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (HERPUD1), partial

Recombinant Human Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (HERPUD1), partial

  • 中文名稱：
    人HERPUD1重組蛋白
  • 貨號：
    CSB-YP622984HU1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人HERPUD1重組蛋白
  • 貨號：
    CSB-EP622984HU1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人HERPUD1重組蛋白
  • 貨號：
    CSB-EP622984HU1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人HERPUD1重組蛋白
  • 貨號：
    CSB-BP622984HU1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人HERPUD1重組蛋白
  • 貨號：
    CSB-MP622984HU1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    HERPUD1; HERP; KIAA0025; MIF1; Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein; Methyl methanesulfonate; MMF-inducible fragment protein 1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated amyloid-beta protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway.
  • 基因功能參考文獻：
    1. This study showed that Herp stability was regulated by synoviolin through lysine ubiquitination-independent proteasomal degradation. PMID: 29863080
    2. HERP plays an important role in the regulation of host innate immunity in response to ER stress during the infection of RNA viruses. PMID: 28954889
    3. results indicated that low expression of miR-9-3p results in a high level of Herpud1, which may protect against apoptosis in glioma PMID: 28430789
    4. Thus, our findings indicated that NQO1 could stabilize Herp protein expression via indirect regulation of synoviolin. PMID: 27084451
    5. The authors found that the CREB3/Herp pathway limited the increase in cytosolic Ca2+ concentration and apoptosis early in poliovirus infection and this may reduce the extent of poliovirus-induced damage to the central nervous system during poliomyelitis. PMID: 27405867
    6. HERPUD1 SNPs are highly associated with polypoidal choroidal vasculopathy. PMID: 26823705
    7. concluded that the HERPUD1-mediated cytoprotective effect against oxidative stress depends on the ITPR and Ca(2+) transfer from the endoplasmic reticulum to mitochondria PMID: 26616647
    8. The results indicate that Nrf1 is a transcriptional activator of Herpud1 expression during ER stress, and they suggest Nrf1 is a key player in the regulation of the ER stress response in cells. PMID: 25637874
    9. Herp operates as a relevant factor in the defense against glucose starvation by modulating autophagy levels. PMID: 24120520
    10. Together with histological grade, increased co-expression of MIF and MMP9 in tumor might be a valuable predictor for recurrence, especially for benign meningiomas PMID: 23372434
    11. binding of Herp to Hrd1-containing ERAD complexes positively regulates the ubiquitylation activity of these complexes, thus permitting survival of the cell during ER stress. PMID: 21149444
    12. The results suggest that ERAD molecule Herp may delay the degradation of cytosolic proteins at the ubiquitination step. PMID: 20604806
    13. Herp mimics structural determinants of DNA immunologically and can be immunogenic in vivo. Thus, Herp represents a candidate autoantigen for anti-DNA antibodies. PMID: 20147634
    14. Data show that that 4-trifluoromethyl-celecoxib can inhibit secretion but not transcription of IL-12 (p35/p40) and IL-23 (p40/p19 heterodimers), and that this is associated with HERP function in the endoplasmic reticulum. PMID: 20054003
    15. enhances presnilin-mediated generation of amyloid beta protein PMID: 11799129
    16. upregulation by Wnt-1 PMID: 12153396
    17. may associate through its ubiquitin-like domain with the 26S proteasome, in this way connecting the protein degradation machinery to the ER membrane and resulting in an efficient ERAD PMID: 12370023
    18. The ubiquitin-like domain of Herp most likely plays a role in the regulation of the intracellular level of Herp under ER stress PMID: 14550564
    19. Results report the identification of Herp, a gene involved in ER stress-associated protein degradation (ERAD), as a direct target of Luman. PMID: 16940180
    20. We identified the transcription factor binding site AARE (amino acid response element) by mutational analysis involved in Herp induction in SH-SY5Y cells, and the more significant role of the CREB binding site compared to AARE in HEK 293T cells. PMID: 17020760
    21. Herp is in a complex with ubiquitinated proteins and with the 26S proteasome, suggesting that it plays a role in linking substrates with the proteasome. PMID: 18042451
    22. Our data suggest that Herp binding to ubiquilin proteins plays an important role in the ERAD pathway and that ubiquilins are specifically involved in degradation of only a subset of ubiquitinated targets, including Herp-dependent ERAD substrates. PMID: 18307982
    23. Type II alcoholic patients had a statistically significant higher expression of Herp mRNA due to upregulation of the expression of this neuroprotective cell non-chaperone by toxic effects of ethanol. PMID: 19251110
    24. the underlying molecular mechanism(s) whereby Herp counteracts Ca(2+) disturbances will provide insights into the molecular cascade of cell death in dopaminergic neurons PMID: 19447887
    25. Herp may play a role in the initiation of the well-known inflammation-like changes in Parkinson disease substantia nigra and serve as a molecular link between degeneration and neuroinflammation in Parkinson disease PMID: 19788048
    26. Expression of Herp protein is up-regulated in response to ER stress, including homocysteine. PMID: 17020760

    顯示更多

    收起更多

  • 亞細胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 組織特異性：
    Widely expressed; in the brain, expression seems to be restricted to neurons and vascular smooth muscle cells. Present in activated microglia in senile plaques in the brain of patients with Alzheimer disease.
  • 數據庫鏈接：

    HGNC: 13744

    OMIM: 608070

    KEGG: hsa:9709

    STRING: 9606.ENSP00000409555

    UniGene: Hs.146393



主站蜘蛛池模板： 亚洲老妇色熟女老太| 亚洲产国偷v产偷v自拍色戒| 久久久久女人精品毛片| 三级做a全过程在线观看| 午夜精品电影你懂的| 不卡av中文字幕手机看| 国产午夜无码片在线观看| 亚欧色一区w666天堂| 亚洲成av人片一区二区| 精品亚洲国产成av人片传媒| 久久中文精品无码中文字幕| 俺去啦俺来也五月天| 亚洲精品久久久久一区二区| 好了av四色综合无码| 中文字幕亚洲乱码熟女在线| 精品国产小视频在线观看| 成人自慰女黄网站免费大全| 网禁拗女稀缺资源在线观看 | 巨胸不知火舞露双奶头无遮挡| 乱子轮熟睡1区| 97一期涩涩97片久久久久久久| 国内精品久久久久影院优| 一区二区传媒有限公司| 99久热在线精品视频观看| 呦男呦女视频精品八区| 国产婷婷亚洲999精品小说| 亚洲国产日韩欧美综合a| 无码人妻一区二区三区线| 国产成人精品一区二区3| 久久人妻无码aⅴ毛片a片app| 成人爽a毛片在线视频淮北| 日韩欧美亚洲国产精品字幕久久久 | 在线人人车操人人看视频| 国产亚洲精品电影网站在线观看| 蜜臀avwww国产天堂| 少妇一边呻吟一边说使劲视频| 国产精品亚洲一区二区三区喷水 | 欧美大浪妇猛交饥渴大叫| 欧美成人精精品一区二区| 国产女主播白浆在线看| 日日鲁鲁鲁夜夜爽爽狠狠视频97 |