在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Homeobox protein Nkx-2.1 (NKX2-1)

  • 中文名稱:
    人NKX2-1重組蛋白
  • 貨號:
    CSB-EP015841HU
  • 規格:
    ¥1836
  • 圖片:
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP015841HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) NKX2-1.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP015841HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) NKX2-1.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
  • Uniprot No.:
  • 別名:
    AV026640; BCH; Benign chorea ; BHC; Homeobox protein NK 2 homolog A; Homeobox protein NK-2 homolog A; Homeobox protein Nkx 2.1; Homeobox protein Nkx-2.1; Homeobox protein Nkx2.1; NK 2; NK 2 homolog A; NK2; NK2 homeobox 1; NK2; drosophila; homolog of; A; NK2.1; mouse; homolog of; Nkx 2 1; NKX 2.1; NKX 2A; NKX2 1; Nkx2-1; NKX2.1; NKX21_HUMAN; NKX2A; T EBP; T/EBP; TEBP; Thyroid nuclear factor 1; Thyroid nuclear factor; Thyroid specific enhancer binding protein; Thyroid transcription factor 1; Tin man; Tinman; TITF 1; TITF1; TTF 1; TTF-1; TTF1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length
  • 來源:
    E.coli
  • 分子量:
    46.0 kDa
  • 表達區域:
    1-371aa
  • 氨基酸序列
    MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPTAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGTGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAASLQGHAQQQAQHQAQAAQAAAAAISVGSGGAGLGAHPGHQPGSAGQSPDLAHHAASPAALQGQVSSLSHLNSSGSDYGTMSCSTLLYGRTW
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Tris-based buffer,50% glycerol
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1.
  • 基因功能參考文獻:
    1. We observed that hyaline membrane disease is the most common cause of perinatal death among respiratory disorders, and in this disease, the expression of TTF-1 is significantly reduced in terminal bronchioles, distal airways, and alveoli compared to the control group. PMID: 30004050
    2. NKX2-1 expression was upregulated in never-smokers , lung adenocarcinoma and patients with wild-type TP53. A negative correlation between NKX2-1 and miR-365 expression was found but there was no correlation between NKX2-1 and miR-33a expression. NKX2-1 expression impacts prognosis in early-stage non-small cell lung cancer patients, particularly in those with neither TP53 nor KRAS mutations. PMID: 29237428
    3. Study shows that that NKX2-1 directly and positively regulates transcription of cyclin D1 in lung adenocarcinoma. Also, the expression of NKX2-1, but not cyclin D1, is significantly associated with metastatic incidence as an independent good prognostic factor of adenocarcinoma. PMID: 28634225
    4. Case Report: TTF-1 expression in of a soft tissue metastasis of mediastinal non-functioning paraganglioma. PMID: 29517207
    5. Loss of NKX2-1 is associated with cancer. PMID: 29587142
    6. TTF-1 might be involved in lymph node metastasis of ovarian carcinomas in the presence of lymphangiogenesis PMID: 28843751
    7. results indicate that TTF-1 expression in NECs suggests a possible role in their normal development and differentiation PMID: 25722034
    8. Combined genomic and proteomic analyses demonstrated infrequent alteration of validated lung cancer targets but identified novel potential targets for TTF1-negative LUAD, including KEAP1/Nrf2 and DNA repair pathways PMID: 25878335
    9. Low expression levels of TTF-1 is associated with lung adenocarcinoma. PMID: 25982999
    10. Immunohistochemical comparison of two TTF-1 mAbs in atypical squamous lesions and sarcomatoid carcinoma of the lung, and pleural malignant mesothelioma suggest possibility for diagnostic errors. PMID: 26281863
    11. Because TTF-1 is not detected in the vast majority of cases using a separate antibody clone, 8G7G3/1, we conclude that aberrant staining is due to cross-reactivity to unknown antigen(s). TTF-1 positivity and even Napsin A positivity, therefore, cannot be used as conclusive evidence of pulmonary origin and gastrointestinal origin must be considered in the differential diagnosis PMID: 26469324
    12. CK7, TTF-1 and napsin A are predominantly expressed in primary lung adenocarcinoma patients, with CDX-2 being inconsistently expressed. PMID: 26469326
    13. Study showed that TTF1 expression was upregulated in tumor tissues from patients with hepatocellular carcinoma (HCC) and that TTF1 mRNA levels were significantly associated with poor prognoses. Moreover, upregulation of TTF1 was shown to promote the proliferation of HCC cells in vitro. PMID: 26821084
    14. P-AKT and TTF-1 using IHC had statistically significant correlation with EGFR mutation with high negative predictive value PMID: 26905105
    15. TTF-1 positivity does not exclude the diagnosis of primary Olfactory neuroblastoma, although usually only a small percentage of cells are positive. PMID: 27543867
    16. TTF-1 immunoreactivity was seen in 19 pulmonary neuroendocrine carcinoma (PNEC) cases (95%) and 13 thymic (TNEC) cases (59.1%). TTF-1 positivity was associated with high sensitivity but low specificity for PNEC, and adding PAX8 negativity significantly increased the specificity. PAX8 positivity alone showed essentially 100% specificity and 86.4% sensitivity for TNEC. PMID: 27761900
    17. Studied the prognostic relevance of thyroid transcription factor 1 (TTF1) copy number alterations (CNAs) and expression levels in non-small cell lung cancer; found TTF1 CNAs and expression high within tumors and between primary and metastatic tumors. PMID: 28378892
    18. it may be useful to combine NAPA and TTF-1 for increased sensitivity in lung cancer diagnostics. There is no substantial difference between monoclonal and polyclonal p40 and between different NAPA clones, whereas there is a difference between the TTF-1 clones 8G7G3/1 and SPT24 PMID: 26447895
    19. TTF-1 shows significant potential as a diagnostic marker to differentiate metastatic pulmonary from non-pulmonary adenocarcinomas in pleural or other effusions. PMID: 26806377
    20. Thyroid Transcription Factor 1 Alters the Expression Profiles of Cytokine and Angiogenic Factors of Lung Cancer Cells. PMID: 26912193
    21. TTF1-expression had no significant impact on outcomes after irradiation of limited-disease small cell lung cancer. PMID: 27354614
    22. our findings show that miR-532-5p is a novel transcriptional target of TTF-1 that plays a tumor suppressive role by targeting KRAS and MKL2 in lung adenocarcinoma PMID: 28474808
    23. The genetic or epigenetic inactivation of NKX2-1/TTF-1 may play an essential role in the development and aberrant differentiation of non-TRU-type lung adenocarcinomas. PMID: 28677170
    24. OLIG2 immunoreactivity was observed in GABAergic cells of the proliferative zones of the MGE and septum, but not necessarily co-expressed with NKX2.1, and OLIG2 expression was also extensively seen in the LGE, CGE, and cortex PMID: 27905023
    25. the downregulation of NKX2-1 in IL-5+ NPs may be associated with tissue eosinophilia and goblet cells hyperplasia PMID: 28318118
    26. In conclusion, TTF-1 is a useful marker in distinguishing subependymal giant cell astrocytoma from its mimics. Expression of TTF-1 in the fetal medial ganglionic eminence indicates that subependymal giant cell astrocytoma may originate from the progenitor cells in this region. PMID: 27910945
    27. Low NKX2-1 expression is associated with thyroid carcinomas. PMID: 27036019
    28. One familial cohort reported that Neuroendocrine cell hyperplasia of infancy (NEHI) is associated with a heterozygous variant of NKX2.1/TTF1. Four adult relatives with heterozygous NKX2.1 mutation and with clinical histories compatible with NEHI enrolled. Although clinical improvement occurs over time, NEHI may result in lifelong pulmonary abnormalities in some cases. PMID: 27187870
    29. Patient-related factors modify the predisposition to papillary thyroid carcinoma by increasing the risk for rs944289 (near the NKX2-1 locus) per year of age, and by enhancing the protective effect of the FOXE1 GGT haplotype in men. PMID: 28660995
    30. The homeobox domain-containing transcription factor NKX2.1 is highly expressed in the medial ganglionic eminence (MGE) and pre-optic area of the ventral subpallium and is essential for specifying cortical interneuron fate. PMID: 27539622
    31. We demonstrated that the 14q13.2q21.1 deletion, which encompasses NKX2-1, but not FOXG1 gene and HPE8 region, identifies a well defined, more benign, microdeletion syndrome PMID: 27148860
    32. Findings suggest that the novel non-transcriptional function of TTF-1 identified in this study may contribute to lung adenocarcinoma development by conferring tolerance to DNA RS, which is known to be inherently elicited by activation of various oncogenes. PMID: 28192407
    33. Immunohistochemical detection of thyroid transcription factor 1, Napsin A, and P40 fragment of TP63 can be used in the subclassification of non-small cell lung carcinomas. PMID: 27045515
    34. The rate of TTF-1-positive circulating tumor cells was strongly correlated with TNM staging, vascular infiltration, lymphatic metastasis, and the levels of CA125, CA15.3, and HE4 in endometrial carcinoma. PMID: 28039713
    35. Study postulated that both TTF-1 and PAX-8 when co-expressed and have anti-proliferative and anti-tumorigenic properties up to a threshold expression level and beyond that, are able to induce pro-tumorigenic effects in thyroid carcinomas. PMID: 27573549
    36. Results suggest that the thyroid transcription factor 1 expression was independently associated with progression-free survival and overall survival in patients with advanced-stage non-squamous non-small cell lung cancer treated with pemetrexed-based chemotherapy. PMID: 28218046
    37. These findings describe recurrent NKX2-1 mutations in invasive mucinous adenocarcinomas of the lung and support NKX2-1 as a lineage-specific tumor suppressor gene in lung carcinogenesis. PMID: 26829311
    38. Report TTF1 expression is common in combined Merkel cell carcinoma. PMID: 27322785
    39. Preoperative serum miR-365 and TTF-1 mRNA levels may be effective indicators of tumor aggressiveness in human NSCLC. miR-365 and its target gene TTF-1 appear to be synergistic risk factors for the reduction in overall survival of patients with NSCLC. PMID: 26337230
    40. In adenocarcinomas from extrahepatic biliary tract, there was no correlation between TTF-1 expression and the clinicopathological characteristics. PMID: 26316052
    41. Suggest TTF-1 is a reliable marker in non-small cell lung carcinoma and can be used in differential diagnosis. PMID: 26456962
    42. genetic susceptibility to thyroid cancer seems likely to be associated with the risk allele at rs944289 PMID: 26206751
    43. EGFR knockdown led to upregulation of NKX2-1, suggesting a negative feedback loop. combined knockdown of NKX2-1 and EGFR in NCI-H1819 lung cancer cells reduced cell proliferation more than knockdown of either alone. PMID: 26556242
    44. TTF-1 had no prognostic value concerning OS, but may serve as a predictor for response to first line chemotherapy in small cell lung cancer. PMID: 25889870
    45. Authors suggest that NKX2-1 as a tumour suppressor or a tumour promoter in lung adenocarcinoma progression is dependent on p53 status. PMID: 25881545
    46. TTF-1 is considered to be an excellent marker of pituicytes, specialized glia of the neurohypophysis. PMID: 25893822
    47. Aberrant expression of mir-365/TTF-1 may be involved in the tumor development in patients with non-small cell lung carcinoma. PMID: 26045746
    48. Different staining patterns can be seen with CK5/6 and p63; however, if they are used together with TTF-1 they can be used in subtyping lung neoplasms. PMID: 25944390
    49. No TTF1 or EAP1 germline mutations were associated with central pubertal disorders. TTF1 and EAP1 may affect puberty by changing expression in response to other members of puberty-associated gene networks PMID: 24051510
    50. Loss of TTF-1 is associated with low response to chemotherapy in non-small-cell lung cancer. PMID: 24457236

    顯示更多

    收起更多

  • 相關疾病:
    Chorea, hereditary benign (BHC); Choreoathetosis and congenital hypothyroidism with or without pulmonary dysfunction (CAHTP); Thyroid cancer, non-medullary, 1 (NMTC1)
  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    NK-2 homeobox family
  • 組織特異性:
    Thyroid and lung.
  • 數據庫鏈接:

    HGNC: 11825

    OMIM: 118700

    KEGG: hsa:7080

    STRING: 9606.ENSP00000346879

    UniGene: Hs.94367



主站蜘蛛池模板: 国模无码大尺度一区二区三区| 天干天干夜啦天干天干国产 | 天堂а√中文最新版在线| 久久人妻国产精品| 亚洲熟妇av综合网五月| 加勒比色综合久久久久久久久| 男女啪动最猛动态图| 搡8o老女人老妇人老熟| 高潮毛片无遮挡高清视频播放| 国产α片免费观看在线人| 一本一道久久综合久久| 新香蕉少妇视频网站| 久久久久成人精品无码| 亚洲一区二区三区无码久久| 特级欧美插插插插插bbbbb| 国产美女久久精品香蕉| 亚洲午夜久久久精品影院| 亚洲精品少妇30p| 99视频精品全部免费 在线| 久久久久久伊人高潮影院| 少妇极品熟妇人妻200片| 亚洲 欧美 变态 另类 综合| 狠狠色狠狠色综合日日不卡 | 成人永久免费网站在线观看| 两个人日本www免费版| 印度妓女野外xxww| 亚洲欧洲成人a∨在线| 成人永久免费网站在线观看| 国产精品国产三级欧美二区| 成人亚洲欧美日韩在线观看| 久久精品一本到东京热| 中国内地毛片免费高清| 亚洲中文字幕乱码电影| 少妇人妻挤奶水中文视频毛片| 青青草免费公开视频| 久久精品99久久香蕉国产色戒| 亚洲国产婷婷香蕉久久久久久| 午夜男女无遮掩免费视频| 小泽玛利亚一区二区在线观看| 99国产精品人妻噜啊噜| 一本大道一卡2卡三卡4卡国产|