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  4. Recombinant Human Homeobox protein Hox-A5 (HOXA5)

Recombinant Human Homeobox protein Hox-A5 (HOXA5)

  • 中文名稱：
    人HOXA5重組蛋白
  • 貨號：
    CSB-YP010655HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人HOXA5重組蛋白
  • 貨號：
    CSB-EP010655HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人HOXA5重組蛋白
  • 貨號：
    CSB-EP010655HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人HOXA5重組蛋白
  • 貨號：
    CSB-BP010655HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人HOXA5重組蛋白
  • 貨號：
    CSB-MP010655HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    HOXA5
  • Uniprot No.：
  • 別名：
    Homeo box 1C; Homeo box A5; Homeobox A5; Homeobox protein Hox-1C; Homeobox protein Hox-A5; Homeobox protein HOXA5; HOX 1; HOX 1.3; HOX 1C; HOX1; HOX1.3; HOX1C; HOXA5; HXA5_HUMAN; MGC9376; OTTHUMP00000217259
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-270
  • 氨基酸序列
    MSSYFVNSFC GRYPNGPDYQ LHNYGDHSSV SEQFRDSASM HSGRYGYGYN GMDLSVGRSG SGHFGSGERA RSYAASASAA PAEPRYSQPA TSTHSPQPDP LPCSAVAPSP GSDSHHGGKN SLSNSSGASA DAGSTHISSR EGVGTASGAE EDAPASSEQA SAQSEPSPAP PAQPQIYPWM RKLHISHDNI GGPEGKRART AYTRYQTLEL EKEFHFNRYL TRRRRIEIAH ALCLSERQIK IWFQNRRMKW KKDNKLKSMS MAAAGGAFRP
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'.
  • 基因功能參考文獻：
    1. HOXA5 functions as a tumor suppressor in regulating tumor growth of gastric cancer (GC) under regulation of miR-196a, supporting its potential utility as a therapeutic target for GC. PMID: 30267809
    2. LncRNA GAS5 depressed OA development by targeting miR-196a-5p and thereby down-regulating HOXA5 expression, providing substance for developing lncRNA-based strategies to treat OA. PMID: 30201235
    3. Low HOXA5 expression is associated with Gastric cancer. PMID: 30015922
    4. Research demonstrated that depletion of HOXA5 inhibited osteogenic differentiation and repressed cell proliferation by arresting cell cycle progression at the S phase via p16(INK4A) , p18(INK4C) , and Cyclin A in SCAPs, indicating that HOXA5 has a significant role in maintaining the proliferation and differentiation potential of dental-tissue-derived MSCs. PMID: 28833816
    5. The study demonstrated that MPP8 was associated with non-small cell lung cancer cell proliferation through regulation of HOXA5. PMID: 29412790
    6. The present study demonstrates that HOXA5 can be silenced in the psoriatic stratum corneum due to DNA methylation of the CGI located in the 5' region of HOXA5. PMID: 28482119
    7. study implicates HOXA5 as a chromosome 7-associated gene-level locus that promotes selection for gain of whole chromosome 7 and an aggressive phenotype in glioblastoma. PMID: 29632085
    8. HOXA5 could bind in the promoter of linc00312 and up-regulated the expression of it. PMID: 28338293
    9. HOXA5 was identified as a tumor suppressor gene, which inhibited non-small-cell lung cancer metastasis by regulating cytoskeletal remodeling. Its expression is repressed by linc00673 through binding with EZH2. PMID: 28423732
    10. lung cancer stem-like cells have plasticity under a condition of oxidative stress, and HOAX5 has a critical role in dedifferentiation PMID: 27418136
    11. loss of HOXA5 in mammary cells leads to loss of epithelial traits, an increase in stemness and cell plasticity, and the acquisition of more aggressive phenotypes. PMID: 27157614
    12. ATRA may inhibit the proliferation of K562 cells and promote apoptosis by upregulating the HOXA5 mRNA and protein expression. PMID: 27052693
    13. Knockdown of HOXA5 suppressed the proliferation and metastasis of esophageal squamous cell cancer cells. PMID: 27960137
    14. high expression levels of HOXA5 mRNA and protein in children with ALL indicate that HOXA5 is closely associated with childhood ALL. PMID: 26846409
    15. Downregulation of HOXA5 by shRNA may trigger apoptosis and overcome drug resistance in leukemia cells. PMID: 26397212
    16. HOXA5-induced apoptosis was p53-independent. PMID: 26219418
    17. Among the mechanosensitive genes, the two transcription factors, HoxA5 and Klf3, contain cAMP-response-elements methylation of which could serve as a mechanosensitive master switch in gene expression in atherosclerosis. (Review) PMID: 25979369
    18. In colon cancer, HOXA5 is downregulated, and its re-expression induces loss of the cancer stem cell phenotype, preventing tumor progression and metastasis. PMID: 26678341
    19. Ectopic expression of HOXA5 in highly invasive cancer cells suppressed cell migration, invasion, and filopodia formation in vitro and inhibited metastatic potential in vivo. PMID: 25875824
    20. Increased expression of HOXA5 is associated with acute myeloid leukemia. PMID: 25987065
    21. Our findings present that decreased HOXA5 could be identified as a poor prognostic biomarker in nonsmall cell lung cancer and regulate cell proliferation and invasion PMID: 25549794
    22. miR-1271 regulates non-small-cell lung cancer cell proliferation and invasion, via the down-regulation of HOXA5. PMID: 25686496
    23. Our analysis showed that miR-196a suppressed the expression of HOXA5 both at the mRNA and protein levels; knockdown of HOXA5 expression in A549 cells using RNAi was shown to promote NSCLC cell proliferation, migration and invasion. PMID: 22876840
    24. HOXA5 can suppress keratinocytes growth and epidermal formation. PMID: 22464764
    25. since lower levels of HOXA5 predict poor prognosis, this gene may be a novel candidate for development of therapeutic strategies in OSCC. PMID: 22227861
    26. Androgen receptor mutations are associated with altered epigenomic programming as evidenced by HOXA5 methylation. PMID: 21311178
    27. The methylation percentage of HOXA5 in AML patients was higher than that of HOXA5 in control patients. PMID: 20890077
    28. HOXA5 is hypermethylated in clear cell renal cell carcinoma. PMID: 20846263
    29. engineered a p53-mutant breast cancer cell line, Hs578T, to inducibly express HOXA5. Expression of HOXA5 can induce apoptosis through an apoptotic mechanism mediated by caspases 2 and 8. PMID: 14701762
    30. loss of HOXA5 expression could lead to the functional activation of Twist resulting in aberrant cell cycle regulation and promoting breast carcinogenesis PMID: 15545268
    31. analysis of transcriptional targets of HOXA5 by microarray hybridization PMID: 15757903
    32. Hox A5 expression is inconsistent with an angiogenic phenotype; expression of Hox A5 may help to maintain existing vessels in a quiescent, differentiated state. PMID: 16379594
    33. HOXA5 is a transcriptional regulator of hMLH1 in breast cancer cells PMID: 16756717
    34. HOXA5 expression was maintained at stable levels at different reproductive stages of a woman's life, except during lactation. HOXA5 protein expression levels in breast carcinomas inversely co-relates with Epidermal Growth Factor Receptor expression. PMID: 17167183
    35. Study identified hypermethylation and gene inactivation of HOXA4 and HOXA5 was frequently observed (26-79%) in all types of leukemias studied. PMID: 17785556
    36. HOXA5 acts directly downstream of RARbeta and may contribute to retinoid-induced anticancer and chemopreventive effects. PMID: 17804711
    37. miR-130a is a regulator of the angiogenic phenotype of vascular endothelial cells largely through its ability to modulate the expression of GAX and HOXA5 PMID: 17957028
    38. The promoter methylation status of a panel of critical growth regulatory genes, RASSF1A, RARbeta2, BRCA1 and HOXA5, in 54 breast cancers and 5 distant normal breast tissues of Indian patients, was analyzed. PMID: 18538349
    39. Epigenetic inactivation of Homeobox A5 gene is associated with nonsmall cell lung cancer. PMID: 19554572

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Antp homeobox family
  • 數據庫鏈接：

    HGNC: 5106

    OMIM: 142952

    KEGG: hsa:3202

    STRING: 9606.ENSP00000222726

    UniGene: Hs.655218



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