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  4. Recombinant Human High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (PDE8B), partial

Recombinant Human High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (PDE8B), partial

  • 中文名稱：
    人PDE8B重組蛋白
  • 貨號(hào)：
    CSB-YP529743HU
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱：
    人PDE8B重組蛋白
  • 貨號(hào)：
    CSB-EP529743HU
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱：
    人PDE8B重組蛋白
  • 貨號(hào)：
    CSB-EP529743HU-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人PDE8B重組蛋白
  • 貨號(hào)：
    CSB-BP529743HU
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人PDE8B重組蛋白
  • 貨號(hào)：
    CSB-MP529743HU
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    PDE8B
  • Uniprot No.：
  • 別名：
    3' 5' cyclic nucleotide phosphodiesterase 8B; 3'5' cyclic nucleotide phosphodiesterase 8B ; Cell proliferation-inducing gene 22 protein; FLJ11212; High affinity cAMP specific and IBMX insensitive 3' 5' cyclic phosphodiesterase 8B; High affinity cAMP specific and IBMX insensitive 3'5' cyclic phosphodiesterase 8B; High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B; HSPDE 8B; HsPDE8B; PDE 8B; PDE8B; PDE8B_HUMAN; Phosphodiesterase 8B; Phosphodiesterase8B; PIG22
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland.
  • 基因功能參考文獻(xiàn)：
    1. Single-nucleotide polymorphism in PDE8B gene is associated with Hashimoto's thyroiditis. PMID: 28382505
    2. replication confirmed at genome-wide significance the association of loci at FOXE1 with hypothyroidism, and PDE8B, CAPZB and PDE10A with serum TSH. A total of 12 SNPs seemed to explain nearly 7% of the serum TSH variation PMID: 28727628
    3. a heterozygous nonsense mutation in the first exon of cyclic nucleotide phosphodiesterase 8B gene, which is predicted to disrupt all important functional domains of the cyclic nucleotide phosphodiesterase 8B protein, in two members of family with autosomal-dominant striatal degeneration PMID: 26769607
    4. Genetic variation of the PDE8B gene may be involved in the etiology of subclinical hypothyroidism in pregnant women. PMID: 25822812
    5. A prevalence of the minor allele of PDE8B gene polymorphism associated with elevated serum levels of TSH was demonstrated in patients affected by sporadic nonautoimmune subclinical hypothyroidism. PMID: 24497218
    6. rs4704397 is associated with thyroid function, risk of MI, and body height. PMID: 23941514
    7. rs4704397 in phosphodiesterase 8B is associated with thyrotropin and thyroid hormone concentrations PMID: 23272636
    8. There is an association between homozygous A/A as well as homozygous G/G carriers of SNP rs 4704397 in PDE8B and recurrent miscarriage. PMID: 23237535
    9. PDE8B gene polymorphisms may be correlated with hyperthyroxinemia in the Chinese Han population. PMID: 22781450
    10. PDE8B is another PDE gene in which variations may contribute to predisposition of adrenocortical tumours. PMID: 22335482
    11. In obese children, PDE8B is associated with TSH; the interaction between adiposity and PDE8B on TSH is not synergistic, but follows an additive model. PMID: 22084153
    12. Common genetic variation in PDE8B is associated with reciprocal changes in thyroid hormone levels. PMID: 21317282
    13. Our analysis revealed separate segregation of an inactivating PDE8B allele from the high-TSH-allele and showed low TSH levels in persons who carry an inactivating PDE8B allele. These data suggest that PDE8B may be involved in regulation of TSH levels. PMID: 20373981
    14. phosphodiesterase 8B has a role in autosomal-dominant striatal degeneration PMID: 20085714
    15. selective usage of exons produces three different PDE8B variants that exhibit a tissue-specific expression pattern PMID: 12372422
    16. Comparison of enzymatic characterization and gene organization of PDE8B and PDE8A. PMID: 12681444
    17. In Alzheimer's disease brains we found that PDE8B was the only PDE isozyme showing a significant increase, in cortical areas and parts of the hippocampal formation, at Braak stages III-VI PMID: 12895443
    18. PDE8B is another PDE gene linked to isolated micronodular adrenocortical disease; it is a candidate causative gene for other adrenocortical lesions linked to the cAMP signaling pathway and possibly for tumors in other tissues. PMID: 18431404
    19. results suggest a primary effect of PDE8B variants on cAMP levels in the thyroid. This would affect production of T4 and T3 and feedback to alter TSH release by the pituitary. PMID: 18514160
    20. Genetic variation in thyroid stimulating hormone levels in pregnancy associated with the PDE8B rs4704397 genotype has implications for the number of women treated for subclinical hypothyroidism under current guidelines PMID: 19820008

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  • 相關(guān)疾病：
    Striatal degeneration, autosomal dominant 1 (ADSD1); Primary pigmented nodular adrenocortical disease 3 (PPNAD3)
  • 蛋白家族：
    Cyclic nucleotide phosphodiesterase family, PDE8 subfamily
  • 組織特異性：
    Abundantly expressed in the thyroid. Also very weakly expressed in brain, spinal cord and placenta. In the thyroid isoform 1 predominates, and isoforms 2 and 6 are also highly expressed. In the placenta isoforms 1 and 2 are expressed equally. In the brain
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 8794

    OMIM: 603390

    KEGG: hsa:8622

    STRING: 9606.ENSP00000264917

    UniGene: Hs.584830



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