在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Hematological and neurological expressed 1 protein (HN1)

  • 中文名稱(chēng):
    人HN1重組蛋白
  • 貨號(hào):
    CSB-BP890732HU
  • 規(guī)格:
  • 來(lái)源:
    Baculovirus
  • 其他:
  • 中文名稱(chēng):
    人HN1重組蛋白
  • 貨號(hào):
    CSB-EP890732HU-B
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱(chēng):
    人HN1重組蛋白
  • 貨號(hào):
    CSB-MP890732HU
  • 規(guī)格:
  • 來(lái)源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
    HN1
  • Uniprot No.:
  • 別名:
    Androgen regulated protein 2; Androgen-regulated protein 2; ARM2; Hematological and neurological expressed 1; Hematological and neurological expressed 1 protein; HN1; HN1_HUMAN; HN1A
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度:
    Hematological and neurological expressed 1 protein, N-terminally processed
  • 表達(dá)區(qū)域:
    2-154aa
  • 氨基酸序列
    TTTTTFKGVDPNSRNSSRVLRPPGGGSNFSLGFDEPTEQPVRKNKMASNIFGTPEENQASWAKSAGAKSSGGREDLESSGLQRRNSSEASSGDFLDLKGEGDIHENVDTDLPGSLGQSEEKPVPAAPVPSPVAPAPVPSRRNPPGGKSSLVLG
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Modulates negatively AKT-mediated GSK3B signaling. Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions. Plays a role in the regulation of cell cycle and cell adhesion. Has an inhibitory role on AR-signaling pathway through the induction of receptor proteosomal degradation.
  • 基因功能參考文獻(xiàn):
    1. Downregulation of MYC abrogated the effect of HN1 overexpression in breast cancer cell lines. Taken together, these data reveal that HN1 promotes the progression of breast cancer by upregulating MYC expression, and might be a therapeutic target for breast cancer. PMID: 28490334
    2. Data report that HN1 is an essential factor for beta-catenin turnover and signaling, augments cell growth and migration in prostate cancer cells. PMID: 25169422
    3. miR-132 is significantly down-regulated in breast cancer tissues and cancer cell lines. Additional study identifies HN1 as a novel direct target of miR-132. MiR-132 down-regulates HN1 expression by binding to the 3' UTR of HN1. PMID: 25450365
    4. HN1 maintains a balance between the androgen-regulated nuclear translocation of androgen receptor and steady-state Akt phosphorylation, predominantly in the absence of androgens. PMID: 22155408
    5. EGF and kinase inhibitors increase HN1 expression, and Silencing of HN1 results in cell cycle alterations in prostate cells. PMID: 21323578
    6. These data suggest a role for Hn1 in the biology of malignant brain tumors. PMID: 19145478

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Nucleus. Cytoplasm.
  • 蛋白家族:
    JUPITER family
  • 組織特異性:
    Expressed in testis, skeletal muscle, thymus, prostate, colon, peripheral blood cells, brain and placenta.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 14569

    KEGG: hsa:51155

    STRING: 9606.ENSP00000348316

    UniGene: Hs.532803



主站蜘蛛池模板: 国产成年码av片在线观看| 久久中文字幕人妻熟av女蜜柚m | 久久久国产精品麻豆a片| 国精产品一区一区三区免费视频| 久久久精品免费| 国产成人亚洲精品无码h在线| 黑人巨茎大战俄罗斯美女| 国产美女爽到尿喷出来视频| 色婷婷狠狠97成为人免费| 欧美精品久久96人妻无码| 亚洲va韩国va欧美va| 日韩夜夜高潮夜夜爽无码| 起碰免费公开97在线视频| 国产成人午夜福利在线观看视频| 亚洲a∨精品永久无码| 日本乱码一区二区三区不卡| 久久久久亚洲精品| 久久婷婷五月国产色综合| 少妇的肉体k8经典| 亚洲国产精品久久久久爰| 中国少妇内射xxxhd免费| 女人高潮内射99精品| 免费看成人欧美片爱潮app| 果冻传媒2021精品一区| 精品国产午夜理论片不卡精品| 天天躁日日躁aaaaxxxx| 中文天堂在线www| 欧洲免费无线码在线一区| 动漫无遮挡羞视频在线观看| 美女又大又黄www免费网站| 国产95在线 | 亚洲| 精品夜夜澡人妻无码av| 国产成人无码牲交免费视频| 久久精品国产成人午夜福利| 最新国产在线拍揄自揄视频| 国产麻豆剧传媒精品av | 亚洲色成人四虎在线观看| 日本xxx在线观看免费播放| 人妻夜夜添夜夜无码av| 亚洲国产成人久久一区二区三区| 亚洲美女高清aⅴ视频免费|