在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Growth arrest and DNA damage-inducible proteins-interacting protein 1 (GADD45GIP1)

Recombinant Human Growth arrest and DNA damage-inducible proteins-interacting protein 1 (GADD45GIP1)

  • 中文名稱：
    人GADD45GIP1重組蛋白
  • 貨號：
    CSB-YP855033HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人GADD45GIP1重組蛋白
  • 貨號：
    CSB-EP855033HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人GADD45GIP1重組蛋白
  • 貨號：
    CSB-EP855033HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人GADD45GIP1重組蛋白
  • 貨號：
    CSB-BP855033HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人GADD45GIP1重組蛋白
  • 貨號：
    CSB-MP855033HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    GADD45GIP1
  • Uniprot No.：
  • 別名：
    39S ribosomal protein L59 mitochondrial; CKBBP2; CKbetaBP2; CKII beta associating protein; CKII beta binding protein 2; CKII beta-associating protein; CR6 interacting factor 1; CR6-interacting factor 1; CRIF1; G45IP_HUMAN; GADD45G interacting protein 1; Gadd45gip1; Growth arrest and DNA damage inducible GADD45G interacting protein; growth arrest and DNA damage inducible, gamma interacting protein 1; Growth arrest and DNA damage-inducible proteins-interacting protein 1; MGC4667; MGC4758; MRP L59; p53 responsive gene 6; p53 responsive gene 6 protein; p53-responsive gene 6 protein; Papillomavirus L2 interacting nuclear protein 1; Papillomavirus L2-interacting nuclear protein 1; PLINP 1; PLINP; PLINP-1; PLINP1; PRG6
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-222
  • 氨基酸序列
    MAASVRQARS LLGVAATLAP GSRGYRARPP PRRRPGPRWP DPEDLLTPRW QLGPRYAAKQ FARYGAASGV VPGSLWPSPE QLRELEAEER EWYPSLATMQ ESLRVKQLAE EQKRREREQH IAECMAKMPQ MIVNWQQQQR ENWEKAQADK ERRARLQAEA QELLGYQVDP RSARFQELLQ DLEKKERKRL KEEKQKRKKE ARAAALAAAV AQDPAASGAP SS
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.
  • 基因功能參考文獻：
    1. NRF2 Ser40 phosphorylation was inhibited in Crif1-deficient bone marrow multipotent mesenchymal stromal cells even in the presence of three kinds of PKC agonists, suggesting that CRIF1 might co-activate PKC-delta to phosphorylate NRF2 Ser40. PMID: 28819452
    2. strongly suggest that CRIF1 deficiency promotes endothelial cell inflammation by increasing VCAM-1 expression, elevating inflammatory cytokines levels, and activating the transcription factor NF-kappaB, all of which were inhibited by SIRT1 overexpression PMID: 29474366
    3. Results demonstrate that knockdown of CRIF1 in HUVECs induces mitochondrial dysfunction and reduces SIRT1 expression along with decreased eNOS phosphorylation and increased eNOS acetylation, thereby promoting endothelial dysfunction. These findings indicate that CRIF1 plays an important role in maintaining mitochondrial and endothelial function through its effects on the SIRT1-eNOS pathway. PMID: 28117598
    4. SNF5 is indispensable for CRIF1-enhanced p53 activity and its function in the suppression of cell cycle arrest in human cancer cells. PMID: 28235567
    5. Study shows that Lck interacts with CRIF1 in the mitochondria and negatively regulates CRIF1-mediated translation of mitochondrion-encoded proteins. PMID: 26210498
    6. our results support a novel function of nuclear Lck in promoting human leukemic T cell survival through interaction with a tumor suppressor, CRIF1 PMID: 25997448
    7. Crif1 is an indispensable regulator of PKAalpha cat that modulates the PKA/CREB signaling pathway to promote adipogenic differentiation of bone marrow mesenchymal stem cells after irradiation PMID: 25847389
    8. The results identify the ROS-Sp1-Crif1 pathway to be a new mechanism underlying Abeta-induced mitochondrial dysfunction and suggest that ROS-mediated downregulation of Crif1 is a crucial event in AD pathology. PMID: 25361083
    9. CRIF1 knockdown partially induces endothelial activation via increased ROS production and phosphorylation of p66shc PMID: 24906005
    10. CRIF1 may play a regulatory role in the BM microenvironment-induced leukemia cell cycle arrest possibly through interacting with CDK2 and acting as a cyclin-dependent kinase inhibitor. PMID: 24520316
    11. CKbetaBP2/CRIF1 is expressed with STAT3 in prostate cancer where STAT3 may help to offset the AR repressor effect of CKbetaBP2/CRIF1. PMID: 24103312
    12. results indicated cell cycle arrest of Jurkat cells in the G0/G1 phase to be induced by primary cultured leukemic BMSCs associated with increased expression of CRIF1 by leukemic cells PMID: 21911160
    13. CRIF1, unlike KEAP1 (which only interacts with N-terminal region of NRF2), physically interacts with both N- and C-terminal regions of NRF2 and promotes NRF2 ubiquitination and subsequent proteasome-mediated NRF2 protein degradation PMID: 20427290
    14. results suggest that CRIF1 is a novel nuclear protein that interacts with Gadd45 and may play a role in negative regulation of cell cycle progression and cell growth PMID: 12716909
    15. Phosphorylation of serine-221 in CKBBP2/CRIF1 promotes proliferation of green monkey COS7 cells. PMID: 17069992
    16. NAC-1 contributes to tumor growth and survival by at least inhibiting Gadd45GIP1 expression, which has a tumor suppressor effect in cancer cells. PMID: 17804717
    17. Results suggest that CRIF1 acts as an AR corepressor and may play an important role in the regulation of AR-positive growth of prostate cancer. PMID: 17885209

    顯示更多

    收起更多

  • 亞細胞定位：
    Mitochondrion. Nucleus.
  • 蛋白家族：
    Mitochondrion-specific ribosomal protein mL64 family
  • 組織特異性：
    Widely expressed. Highly expressed in the thyroid gland, heart, lymph nodes, trachea and adrenal tissues. Expressed at lower level in liver skeletal muscle, kidney, pancreas, testis, ovary and stomach. Barely detectable in adrenal adenoma and papillary th
  • 數據庫鏈接：

    HGNC: 29996

    OMIM: 605162

    KEGG: hsa:90480

    STRING: 9606.ENSP00000323065

    UniGene: Hs.515164



主站蜘蛛池模板： 中文字幕一区二区人妻| 国产多人群p刺激交换视频| 欧美变态口味重另类在线视频 | 永久免费无码网站在线观看个| 国语自产精品视频在线第100页| 欧美做爰性生交视频| 欧美人与动欧交视频| 国产精品国产三级国产an| 国产拍揄自揄精品视频| 东京热人妻中文无码av| 久久综合激激的五月天| 国产美女亚洲精品久久久| 国产精品视频免费一区二区| 国产女人和拘做受视频免费| 人妻精品久久久久中文字幕| 一区二区狠狠色丁香久久婷婷| 亚洲欧美日韩一区二区| 成品人视频ww入口| 久久久亚洲欧洲日产av| 亚洲午夜久久久无码精品网红a片| 无限看片在线版免费视频大全| 人妻丰满熟妇av无码区不卡| 久久久久精品无码一区二区三区 | 国产线观看免费观看| 久久www免费人成_看片老司机| 男人扒开女人腿桶到爽免费| 国产性猛交普通话对白| 天堂а√中文在线| 小泽玛利亚一区二区在线观看| 亚洲精品一品区二品区三品区| 欧美成人精品一区二区综合a片| 国语自产精品视频在线第100页| 韩国乱码伦视频免费| 国产精品原创巨作av女教师| 亚洲精品无码专区在线| 国产精品 视频一区 二区三区 | 人妻插b视频一区二区三区| 热re99久久精品国99热| 欧美成人va免费大片视频| 无线乱码一二三区免费看| 欧美综合自拍亚洲综合图|