在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Granzyme A (GZMA)

Recombinant Human Granzyme A (GZMA)

  • 中文名稱：
    人GZMA重組蛋白
  • 貨號：
    CSB-YP010081HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人GZMA重組蛋白
  • 貨號：
    CSB-EP010081HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人GZMA重組蛋白
  • 貨號：
    CSB-EP010081HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人GZMA重組蛋白
  • 貨號：
    CSB-BP010081HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人GZMA重組蛋白
  • 貨號：
    CSB-MP010081HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    GZMA
  • Uniprot No.：
  • 別名：
    CTL tryptase; CTLA3; Cytolytic t cell and natural killer cell specific trypsin like serine protease; Cytotoxic T lymphocyte associated serine esterase 3; Cytotoxic T lymphocyte proteinase 1; Cytotoxic T-lymphocyte proteinase 1; Fragmentin 1; Fragmentin-1; GRAA_HUMAN; Granzyme 1 cytotoxic T lymphocyte associated serine esterase 3; Granzyme A (Cytotoxic T lymphocyte associated serine esterase 3, Hanukah factor serine protease); Granzyme A (granzyme 1, cytotoxic T lymphocyte associated serine esterase 3); Granzyme A; Granzyme A precursor; Granzyme-1; GZMA; H factor; Hanukah factor serine protease; Hanukkah factor; HF; HFSP; TSP1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    29-262
  • 氨基酸序列
    II GGNEVTPHSR PYMVLLSLDR KTICAGALIA KDWVLTAAHC NLNKRSQVIL GAHSITREEP TKQIMLVKKE FPYPCYDPAT REGDLKLLQL MEKAKINKYV TILHLPKKGD DVKPGTMCQV AGWGRTHNSA SWSDTLREVN ITIIDRKVCN DRNHYNFNPV IGMNMVCAGS LRGGRDSCNG DSGSPLLCEG VFRGVTSFGL ENKCGDPRGP GVYILLSKKH LNWIIMTIKG AV
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-B (GSDMB), releasing the pore-forming moiety of GSDMB, thereby triggering pyroptosis and target cell death. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA.
  • 基因功能參考文獻：
    1. GzmA produced by lesional CD8 T cells has the capacity to specifically increase chemokine secretion from inflamed keratinocytes, thereby sustaining the focal inflammation in psoriasis lesions by amplifying a chemotactic inflammatory loop. PMID: 28094457
    2. granzyme A in human platelets increases with aging PMID: 29167233
    3. GzmA plays an unfavorable role in host defense during pneumococcal pneumonia by a mechanism that does not depend on natural killer cells. PMID: 27343190
    4. Carbamate pesticides significantly reduced the intracellular levels of perforin, GrA, GrB, Gr3/K, and GRN in NK-92CI cells. PMID: 25921628
    5. Our results suggest that granzyme A could be considered another biomarker of TB, that can be used, other than IFN-gamma, to discriminate between patients with active TB and LTBI subjects PMID: 26051682
    6. Delivered into parasite infected cells by granulysin and perforin, granzymes generate superoxide and inactivate oxidative defense enzymes to kill the parasite. PMID: 26752517
    7. Taken together, the authors verified that histone H3 is a real substrate for GzmA in vivo in the Raji cells treated by staurosporin. PMID: 26032366
    8. Results reveal enhanced intra- and extracellular expression of gzmA and B in patients with pulmonary TB, suggesting that gzms are part of the host response to tuberculosis. PMID: 26156785
    9. Levels of GZMA and ITGAE mRNAs in colon tissues can identify patients with UC who are most likely to benefit from etrolizumab; expression levels decrease with etrolizumab administration in biomarker(high) patients. PMID: 26522261
    10. GzmA and GzmB expressing cells in the airways and lung parenchyma was higher in subjects who died from asthma PMID: 25745046
    11. Data indicate N-terminomics on the human and mouse granzymes A and K by combined fractional diagonal chromatography (COFRADIC). PMID: 25383893
    12. We herewith identify GZMA as critical effector molecule of human Treg function for gastrointestinal immune response in an experimental GvHD model. PMID: 25928296
    13. The exocytosed granzyme A enters target cells and mediates IL-1beta maturation independently of caspase-1 and without inducing cytotoxicity. PMID: 25437548
    14. Serum concentrations of granzyme A in patients with ovarian cancer were substantially increased in comparison to concentrations in patients with ovarian cystadenomas or ovarian teratomas. PMID: 24673566
    15. functional divergence between human and mouse granzyme A PMID: 24505135
    16. Patients with chronic immune thrombocytopenia have elevated serum granzyme A levels. PMID: 22476618
    17. A critical and previously unsuspected role is revealed for granzymes A and B in dictating immunogenicity by influencing the mode of tumor cell death. PMID: 21709155
    18. The results indicate that GzmA and GzmB are implicated in mechanisms of neurodegeneration in amyotrophic lateral sclerosis. PMID: 21349256
    19. investigation of substrate specificity toward Jurkat cell proteins; more than 260 cleavage sites, almost exclusively favoring basic residues at the P1 position, in approximately 200 unique protein substrates, were identified PMID: 20536382
    20. Human eosinophils exert TNF-alpha and granzyme A-mediated tumoricidal activity toward colon carcinoma cells. PMID: 21068403
    21. HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A. PMID: 11909973
    22. results demonstrate discordant expression of granzymes A and B in human lymphocyte subsets and T regulatory cells, which suggests that different granzymes may play unique roles in immune system responses and regulation PMID: 15238416
    23. polymorphonuclear leukocytes from mice and humans lack the 3 cytotoxic effector molecules, gzmA, granzyme B, and perforin, generally associated with natural killer and cytotoxic T lymphocytes PMID: 15998831
    24. Mouse granzyme B is 30 times less cytotoxic than human granzyme B and does not require Bid for killing but regains cytotoxicity on engineering of its active site cleft. Mouse granzyme A is considerably more cytotoxic than human granzyme A. PMID: 17116752
    25. GrA expression is increased in type II pneumocytes of patients with very severe COPD. These results indicate that GrA may be important in the development of COPD. PMID: 17138956
    26. GzmK-induced caspase-independent death occurs through Bid-dependent mitochondrial damage that is different from GzmA PMID: 17308307
    27. Report activation of the granzymeA/B pathway in children with severe respiratory syncytial virus infection. PMID: 18317234
    28. GzmA accesses the mitochondrial matrix to cleave the complex I protein NDUFS3, an iron-sulfur subunit of the NADH:ubiquinone oxidoreductase complex I. PMID: 18485875
    29. GZMA causes detachment of alveolar epithelial A549 cells accompanied by interleukin-8 release. PMID: 18776661
    30. the granule secretory pathway plays an unexpected role in inflammation, with GzmA acting as an endogenous modulator PMID: 18951048
    31. Data suggest that 1, 25(OH)(2) vitamin D(3) suppresses granzyme A probably by down-regulating Th1 cytokine response, and tah vitamin D receptor gene variants might regulate cytotoxic T-cell response by suppression of granzyme A expression in tuberculosis. PMID: 19014932
    32. GrK not only constitutes a redundant functional backup mechanism that assists GrA-induced cell death but that it also displays a unique function by cleaving its own specific substrates. PMID: 19059912
    33. The N-terminal GzmA cleavage fragment of PARP-1 acts as a PARP-1 dominant negative, binding to DNA and blocking DNA repair. PMID: 19506301
    34. Granzyme A is a proinflammatory protease. PMID: 19875524

    顯示更多

    收起更多

  • 亞細胞定位：
    [Isoform alpha]: Secreted. Cytoplasmic granule.
  • 蛋白家族：
    Peptidase S1 family, Granzyme subfamily
  • 數據庫鏈接：

    HGNC: 4708

    OMIM: 140050

    KEGG: hsa:3001

    STRING: 9606.ENSP00000274306

    UniGene: Hs.90708



主站蜘蛛池模板： 久久精品国产久精国产| 国产成人无码av在线播放不卡| 日本熟妇色xxxxx欧美老妇| 深夜福利小视频在线观看| 国产98色在线 | 国产| 久久精品国产99国产精2020丨| 日产精品卡2卡三卡乱码网站| 中文字幕无码无码专区| 色综合久久蜜芽国产精品| 国产在线观看无码的免费网站| 美国特级a毛片免费网站| 精产国品一二三产品蜜桃| 疯狂撞击丝袜人妻| 久久精品亚洲精品国产色婷| 国产午夜亚洲精品国产成人| 国产亚洲美女精品久久久2020| 中文在线√天堂| 亚洲综合无码中文字幕第2页| 白丝乳交内射一二三区| 久久无码喷吹高潮播放不卡| 国产成人精品电影在线观看| 亚洲乱码中文字幕在线| 日韩人妻无码一区二区三区综合| 国产人妻精品一区二区三首 | 久久99国产精品成人| 亚洲精品无码国产| 国产亚洲精品第一综合麻豆| 国产精品99久久精品爆乳| 日韩精品一区二区三区在线观看l| 亚洲加勒比少妇无码av| 国产内射老熟女aaaa| 久久久久久a亚洲欧洲av| 欧美日韩亚洲tv不卡久久| 中文字幕亚洲码在线观看| 久久久久女教师免费一区| 少妇激情av一区二区三区| 天干天干啦夜天干天天爽| 巨胸不知火舞露双奶头无遮挡| 欧美亚洲国产精品久久蜜芽 | 午夜免费无码福利视频麻豆| 亚洲欧美成人中文日韩电影网站|