在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Glutamate receptor-interacting protein 1 (GRIP1), partial

Recombinant Human Glutamate receptor-interacting protein 1 (GRIP1), partial

  • 中文名稱：
    人GRIP1重組蛋白
  • 貨號：
    CSB-YP897486HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人GRIP1重組蛋白
  • 貨號：
    CSB-EP897486HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人GRIP1重組蛋白
  • 貨號：
    CSB-EP897486HU-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人GRIP1重組蛋白
  • 貨號：
    CSB-BP897486HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人GRIP1重組蛋白
  • 貨號：
    CSB-MP897486HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    GRIP1
  • Uniprot No.：
  • 別名：
    as GRIP; Glutamate receptor-interacting protein 1; GRIP-1; Grip1; GRIP1_HUMAN
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons. Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting.
  • 基因功能參考文獻：
    1. GRIP1 is phosphorylated at an N-terminal serine cluster by cyclin-dependent kinase-9 (CDK9), which is recruited into GC-induced GR:GRIP1:CDK9 hetero-complexes, producing distinct GRE-specific GRIP1 phospho-isoforms. PMID: 29170386
    2. Data suggest that molecules in the erythropoietin-producing hepatocellular receptor B family (EPHB) / ephrinB (EFNB) signalling pathways, specifically ephrin B3 and GRIP1, are involved blood pressure regulation. PMID: 27941904
    3. GRIP1 was identified as one of the most important differentially expressed, topologically significant proteins in the protein-protein interaction network in Alzheimer's disease. PMID: 27425598
    4. the Trip6-GRIP1-myosin VI interaction and its regulation on F-actin network play a significant role in dendritic morphogenesis PMID: 25673849
    5. In 15 of 590 families, we identified recessive mutations in the genes FRAS1, FREM2, GRIP1, FREM1, ITGA8, and GREM1, all of which function in the interaction of the ureteric bud and the metanephric mesenchyme. PMID: 24700879
    6. In three unrelated families with parental consanguinity, GRIP1 mutations were found to segregate with Fraser syndrome in an autosomal recessive manner. PMID: 22510445
    7. Gain-of-function glutamate receptor interacting protein 1 variants alter GluA2 recycling and surface distribution in patients with autism PMID: 21383172
    8. GRIP1 splice forms interact with gephyrin and play a role in synaptic function at GABAergic and glycinergic synapses in cultured hippocampal neurons. PMID: 18315564
    9. after regulated endocytosis, binding to GRIP/ABP stabilizes the internalized receptors in an intracellular pool and prevents them from being recycled back to the plasma membrane or entering a degradative pathway. PMID: 12011465
    10. GRIP1c 4-7 plays a role not only in glutamatergic synapses but also in GABAergic synapses PMID: 15226318
    11. study showed neither single marker nor haplotype analysis revealed an association between variants at GRIP1 locus & schizophrenia; suggests it is unlikely that the GRIP1 polymorphisms investigated play a substantial role in schizophrenia susceptibility PMID: 17303296
    12. Supramodular nature of GRIP1 revealed by the structure of its PDZ12 tandem in complex with the carboxyl tail of Fras1. PMID: 18155042

    顯示更多

    收起更多

  • 相關疾病：
    Fraser syndrome 3 (FRASRS3)
  • 亞細胞定位：
    Cytoplasmic vesicle. Perikaryon. Cell projection, dendrite. Cytoplasm. Endomembrane system; Peripheral membrane protein. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, postsynaptic density. Endoplasmic reticulum membrane; Peripheral membrane protein.
  • 數據庫鏈接：

    HGNC: 18708

    OMIM: 604597

    KEGG: hsa:23426

    STRING: 9606.ENSP00000381098

    UniGene: Hs.505946



主站蜘蛛池模板： av片在线观看免费| 无码人妻丰满熟妇a片护士| 亚欧免费无码aⅴ在线观看 | 综合 欧美 亚洲日本| 国产精品毛片av在线看| 免费看美女部位隐私网站| 777午夜福利理伦电影网| 亚洲成av人片一区二区三区| 精品国产乱码久久久久久浪潮| 视频在线+欧美十亚洲曰本| 亚洲精品一线二线三线区别大吗 | 日韩人妻无码中文字幕视频| 欧美老熟妇欲乱高清视频| 熟女俱乐部五十路六十路av| 亚洲欧美日本国产专区一区| 国产亚洲999精品aa片在线爽| 少妇被多人c夜夜爽爽| 50路60路老熟妇啪啪| 风韵犹存丰满大屁股熟妇| 一本色道久久综合狠狠躁篇| 亚洲精品成av人片天堂无码| 亚洲精品国产品国语在线| 国产成人片无码免费视频| 人妻少妇无码中文幕久久| 精品人妻无码一区二区色欲产成人| 香蕉av福利精品导航| 人人妻人人爽人人做夜欢视频九色| 久久好在线视频| 精品国精品国产自在久国产应用| 亚洲国产成人精品青青草原| 国产内射在线激情一区| 熟妇无码乱子成人精品| 亚洲人成人网站色www| 国内精品久久久久影院蜜芽| 国产1卡2卡三卡四卡精品| 久久国产成人午夜av影院| 一线二线无人区乱码 | 国产又色又爽又黄的视频在线| 亚洲国产成人综合精品| 日韩精品无码一区二区三区视频| 亚洲欲色欲色xxxxx在线|