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  4. Recombinant Human Glutamate receptor, ionotropic kainate 1 (GRIK1), partial

Recombinant Human Glutamate receptor, ionotropic kainate 1 (GRIK1), partial

  • 中文名稱：
    人GRIK1重組蛋白
  • 貨號：
    CSB-YP009906HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人GRIK1重組蛋白
  • 貨號：
    CSB-EP009906HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人GRIK1重組蛋白
  • 貨號：
    CSB-EP009906HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人GRIK1重組蛋白
  • 貨號：
    CSB-BP009906HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人GRIK1重組蛋白
  • 貨號：
    CSB-MP009906HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    EAA3; EEA3; Excitatory amino acid receptor 3; GLR5; GluR-5; GluR5; GluR6; GluR7; Glutamate receptor 5; Glutamate receptor; Glutamate receptor ionotropic kainate 1; GRIK1; GRIK1_HUMAN; Human glutamate receptor GLUR5; ionotropic kainate 1; OTTHUMP00000096569
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.
  • 基因功能參考文獻：
    1. DRD2 A2/A1, DRD3 Ser9Gly, DbetaH -1021C>T, OPRM1 A118G and GRIK1 rs2832407C>A are not associated with alcoholism alone or in interaction. PMID: 27447243
    2. The findings reported here suggest that, in participants with the GRIK1 rs2832407*CC genotype, topiramate treatment enhances self-efficacy and reduces heavy drinking. PMID: 25496338
    3. Findings indicate that SNPs in the GRIK1 gene is associated with altered cue-induced brain activation that is related to craving for alcohol and relapse risk. PMID: 26289945
    4. Results suggested that the extracellular N-terminal region including the two CUB domains was largely responsible for the distinct regulatory effects of Neto1 and Neto2 on the desensitization properties of GluK1 homomeric receptors PMID: 26277340
    5. In the present study, we have shown that gene-gene interaction of components of different systems associated with nicotine reinforcing effects, such as OPRM1 and GRIK1, rather than one gene polymorphism, is associated with smoking behavior. PMID: 25941919
    6. This found that, among rs2832407*C of GRIK1 homozygotes, topiramate treatment produced the greatest reductions in the expected positive effects of drinking and desire to drink during the treatment period. PMID: 24786948
    7. These results suggest that the effect of topiramate on drinking behavior, in which the GluK1-containing kainate receptor appears to play a key role, can be dissociated from its effect on weight. PMID: 24978347
    8. Topiramate treatment for alcohol dependence was significantly more effective in rs2832407 C-allele homozygotes. PMID: 24525690
    9. Reduced Homer binding to mGluR5 supports an inhibitory role for Homer interactions with mGluR5 in mediating neuropathy. PMID: 23685007
    10. Using the SNaPshot assay, we present evidence for allelic nondisjunction at rs363506 in the GRIK1 gene and rs2834235 and rs7283354 in the GARS-AIRS-GART gene in Down syndrome in India. PMID: 22931243
    11. The association at rs455804 implicates GRIK1 as a novel susceptibility gene for HBV-related HCC, suggesting the involvement of glutamate signaling in the development of HBV-related HCC. PMID: 22807686
    12. GRIK1 rs469472 to be possibly associated with schizophrenia in our independent case-control and family samples PMID: 22730074
    13. Presynaptic Gluk1 kainate receptors that reduce transmitter release downstream are independent of divalent calcium ion Ca2+ influx. PMID: 20848601
    14. The amino acid sequence of the GluK1 kainate receptor near or within the carboxyl-terminal endoplasmic reticulum retention signal sequence, which affects receptor trafficking and/or expression, does not affect channel gating properties. PMID: 22191429
    15. The GRIK1 promoter is activated by Trichostatin A (TSA) treatment and by serum depletion according to promoter reporter assays in HEK 293 cells. PMID: 20494980
    16. findings show GluR5 was upregulated in the hippocampus, but not in the temporal neocortex, of patients with temporal lobe epilepsy (TLE)compared to controls; mossy fiber sprouting in the hippocampus of TLE patients was correlated with GluR5 upregulation PMID: 19941835
    17. Variation in the 3' portion of the gene encoding the GluR5 kainate receptor subunit contributes to the risk for alcohol dependence. PMID: 19320626
    18. GluK1 kainate receptor polymorphisms are associated with Down syndrome. PMID: 19893199
    19. GRIK1 does not play a major role in schizophrenia pathogenesis in the Japanese population PMID: 11702055
    20. there are trafficking signals in the C-terminal domain of GluR5-2b; alternative splicing is an important mechanism regulating KAR function PMID: 14527949
    21. Two amino acids,competitive GluR5 KA receptor antagonists, exhibited high GluR5 receptor affinity over other glutamate receptors. PMID: 15974569
    22. This kainate receptor subunit appears to be selectively altered in the anterior cingulate cortex in schizophrenia and bipolar disorder. PMID: 17698324

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Glutamate-gated ion channel (TC 1.A.10.1) family, GRIK1 subfamily
  • 組織特異性：
    Most abundant in the cerebellum and the suprachiasmatic nuclei (SCN) of the hypothalamus.
  • 數據庫鏈接：

    HGNC: 4579

    OMIM: 138245

    KEGG: hsa:2897

    STRING: 9606.ENSP00000382791

    UniGene: Hs.664641



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