在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Gigaxonin (GAN)

Recombinant Human Gigaxonin (GAN)

  • 中文名稱：
    人GAN重組蛋白
  • 貨號：
    CSB-YP009228HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人GAN重組蛋白
  • 貨號：
    CSB-EP009228HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人GAN重組蛋白
  • 貨號：
    CSB-EP009228HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人GAN重組蛋白
  • 貨號：
    CSB-BP009228HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人GAN重組蛋白
  • 貨號：
    CSB-MP009228HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    GAN
  • Uniprot No.：
  • 別名：
    FLJ38059; GAN (gene name); GAN; GAN_HUMAN; GAN1 (gene name); Gigaxonin; Kelch-like protein 16; KLHL16
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-597
  • 氨基酸序列
    MAEGSAVSDP QHAARLLRAL SSFREESRFC DAHLVLDGEE IPVQKNILAA ASPYIRTKLN YNPPKDDGST YKIELEGISV MVMREILDYI FSGQIRLNED TIQDVVQAAD LLLLTDLKTL CCEFLEGCIA AENCIGIRDF ALHYCLHHVH YLATEYLETH FRDVSSTEEF LELSPQKLKE VISLEKLNVG NERYVFEAVI RWIAHDTEIR KVHMKDVMSA LWVSGLDSSY LREQMLNEPL VREIVKECSN IPLSQPQQGE AMLANFKPRG YSECIVTVGG EERVSRKPTA AMRCMCPLYD PNRQLWIELA PLSMPRINHG VLSAEGFLFV FGGQDENKQT LSSGEKYDPD ANTWTALPPM NEARHNFGIV EIDGMLYILG GEDGEKELIS MECYDIYSKT WTKQPDLTMV RKIGCYAAMK KKIYAMGGGS YGKLFESVEC YDPRTQQWTA ICPLKERRFG AVACGVAMEL YVFGGVRSRE DAQGSEMVTC KSEFYHDEFK RWIYLNDQNL CIPASSSFVY GAVPIGASIY VIGDLDTGTN YDYVREFKRS TGTWHHTKPL LPSDLRRTGC AALRIANCKL FRLQLQQGLF RIRVHSP
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB. Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival.
  • 基因功能參考文獻：
    1. Our protocol showed high specificity and sensitivity for homozygosity detection and facilitated the identification of novel mutations in GAN, GBA2, and ZFYVE26 in four families affected by hereditary spastic paraplegia or Charcot-Marie-Tooth disease PMID: 26492578
    2. We believe that molecular and functional investigation of gigaxonin mutations including the exon 8 polymorphism could lead to an improved understanding of the relationship between GAN and cancer PMID: 27023907
    3. A novel sequence alteration in the gene GAN, c.103G > T, was identified as most likely the underlying cause for a sensory-motor axonal neuropathy in a large consanguineous family presenting as Charcot-Marie-Tooth disease type 2. PMID: 27852232
    4. a proteomic screen to identify the normal binding partners of GIG, is reported. PMID: 26460568
    5. The disease is caused by GAN gene mutations on chromosome 16q24.1. To determine clinical and genetic results in Turkish patients with GAN. PMID: 25533284
    6. This study showed that The instability of Gigaxonin causes Giant Axonal Neuropathy. PMID: 24758703
    7. A novel missense mutation in four siblings born to consanguineous parents of Arab origin with clinical and molecular features compatible with giant axonal neuropathy. PMID: 23332420
    8. gigaxonin is a major factor in the degradation of cytoskeletal intermediate filaments PMID: 23585478
    9. No GAN variant is identified in DNA obtained from well-characterized cases of human neuronal intermediate filament inclusion disease (frontotemporal dementia). PMID: 19782434
    10. Gigaxonin interacts with tubulin folding cofactor B and controls its degradation through the ubiquitin-proteasome pathway. PMID: 16303566
    11. Ubiquitin-proteasome system shown to be responsible for neurodegeneration occurring in GAN-null neurons and plays crucial roles in cytoskeletal functions and dynamics. PMID: 17256086
    12. 3 new mutants were found in patients with giant axonal neuropathy: an intronic mutation near the splice donor site of intron 2 & a missense mutation in exon 3 (I182N), & 2 identical deletion alleles. PMID: 17331252
    13. Five families with GAN for mutations in the Gigaxonin gene and mutations were found in four families; three families had homozygous mutations, one had two compound heterozygous mutations and one family had no mutation identified. PMID: 17578852
    14. gigaxonin mutations impede this ubiquitin degradation process leading to accumulation of microtubule associated proteins and there by impairing cellular functions PMID: 17587580
    15. a functional important part of the gigaxonin protein is altered by the AluYa5 insertion and causes giant axonal neuropathy [case report] PMID: 18595793
    16. Study shows that the gigaxonin E3 ligase subunit is normally expressed at a very low level and that various missense and nonsense mutations scattered across the entire GAN gene produce highly unstable protein products. PMID: 19168853

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Giant axonal neuropathy 1, autosomal recessive (GAN1)
  • 亞細胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton.
  • 組織特異性：
    Expressed in brain, heart and muscle.
  • 數據庫鏈接：

    HGNC: 4137

    OMIM: 256850

    KEGG: hsa:8139

    STRING: 9606.ENSP00000248272

    UniGene: Hs.112569



主站蜘蛛池模板： 97av麻豆蜜桃一区二区| 性生交大片免费看| 久久久久88色偷偷| 人妻系列av无码专区| 亚洲欧美v国产一区二区| 伊人久久大香线焦av综合影院| 亚州av综合色区无码一区| 国产成a人亚洲精v品无码| 久久精品国产久精国产一老狼| 100禁毛片免费40分钟视频| 2020国产精品午夜福利在线观看 | 国产女人高潮叫床免费视频| 欧洲美熟女乱又伦av| 超碰97久久国产精品牛牛| 欧美 日韩 人妻 高清 中文| 国产精品无码一区二区三区 | 欧美真人性做爰全过程| 丰腴饱满的极品熟妇| 偷偷做久久久久网站| 久久婷婷五月综合中文字幕| 国产综合色在线精品| 国产无遮挡裸体免费视频在线观看| 国产精品美脚玉足脚交欧美| 欧美日激情日韩精品嗯| 国产精品va在线观看h| 97人妻天天摸天天爽天天| 欧美人与动牲交xxxxbbbb| 内射巨臀欧美在线视频| 国产精品亚洲mnbav网站| 精品av综合导航| 欧美亚洲国产精品久久高清| 狠狠做深爱婷婷久久综合一区 | 亚洲精品无码av人在线观看国产| 九九精品99久久久香蕉| 无码一区二区波多野结衣播放搜索| 欧美肥婆性猛交xxxx| 成人h无码动漫超w网站| 无码国产精品一区二区免费模式| 国产av无码专区亚洲awww| 三级做a全过程在线观看| 国产精品高潮呻吟av久久男男|