在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Gamma-interferon-inducible lysosomal thiol reductase (IFI30)

  • 中文名稱:
    人IFI30重組蛋白
  • 貨號:
    CSB-YP011012HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人IFI30重組蛋白
  • 貨號:
    CSB-EP011012HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人IFI30重組蛋白
  • 貨號:
    CSB-EP011012HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人IFI30重組蛋白
  • 貨號:
    CSB-BP011012HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    Gamma interferon inducible lysosomal thiol reductase; Gamma interferon inducible protein IP 30 ; Gamma-interferon-inducible lysosomal thiol reductase; Gamma-interferon-inducible protein IP-30; GILT ; GILT_HUMAN; IFI 30; IFI30; interferon gamma inducible protein 30; Interferon gamma inducible protein 30 preproprotein ; IP30 ; Legumaturain; Lysosomal thiol reductase; Lysosomal thiol reductase; gamma-interferon-inducible
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    58-232
  • 氨基酸序列
    NAP LVNVTLYYEA LCGGCRAFLI RELFPTWLLV MEILNVTLVP YGNAQEQNVS GRWEFKCQHG EEECKFNKVE ACVLDELDME LAFLTIVCME EFEDMERSLP LCLQLYAPGL SPDTIMECAM GDRGMQLMHA NAQRTDALQP PHEYVPWVTV NGKPLEDQTQ LLTLVCQLYQ GK
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds. Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation.
  • 基因功能參考文獻:
    1. Results shows that GILT expression is required for downregulation of PAX-3 proteins in late stage human melanoma cells. GILT co-localizes with PAX-3 proteins regulating its expression through the autophagy and lysosomal degradation pathway in human melanoma cells. PMID: 28857256
    2. GILT functions as a host restriction factor against the retroviruses. PMID: 27655726
    3. GILT expression is anticipated to result in improved presentation of melanoma antigens and more effective antimelanoma T-cell responses. PMID: 26930048
    4. The lysosomal thiol reductase GILT expressed by antigen-presenting cells has diverse cellular and organismal functions. (Review) PMID: 26116226
    5. this review discusses recent studies that have advanced our understanding of the role of GILT in antigen processing and revealed surprising new functions for the enzyme.[review] PMID: 23246037
    6. Single nucleotide polymorphism of the interferon-gamma-inducible protein 30 gene is associated with hyperglycemia in severely obese individuals. PMID: 21701784
    7. GILT is required for efficient histocompatiblity class II-restricted processing of melanoma antigen tyrosinase-related protein 1 epitope in vitro and accelerates the onset of vitiligo in TRP1-specific T-cell receptor transgenic mice. PMID: 20668223
    8. Absence of gamma-interferon-inducible lysosomal thiol reductase in melanomas disrupts T cell recognition of select immunodominant epitopes. PMID: 12021307
    9. Role of the C-terminal propeptide in the activity and maturation of gamma -interferon-inducible lysosomal thiol reductase (GILT). PMID: 12198183
    10. GILT-expressing melanoma cells could prove to be very promising for direct antigen presentation and CD4+ T cell recognition PMID: 18343923
    11. studied gene expression profile of brain lesions of a patient with Neuromyelitis optica by using DNA microarray; found marked up-regulation of interferon gamma-inducible protein 30 (IFI30), CD163, and secreted phosphoprotein 1 (SPP1, osteopontin) PMID: 18410276

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted. Lysosome.
  • 蛋白家族:
    GILT family
  • 數據庫鏈接:

    HGNC: 5398

    OMIM: 604664

    KEGG: hsa:10437

    STRING: 9606.ENSP00000384886

    UniGene: Hs.14623



主站蜘蛛池模板: 中文字幕乱码熟妇五十中出色欲 | 亚洲国产精品无码av| 久久人搡人人玩人妻精品| 再深点灬舒服灬太大了网站| 波多野结衣 黑人| 黑人巨茎大战欧美白妇免费| 久久精品国产99久久无毒不卡| 中文在线www天堂网| 无码人妻少妇伦在线电影| 影音先锋男人站| 男女无遮挡猛进猛出免费观看视频 | 久久99精品久久久久久| 97国产精东麻豆人妻电影| 野外少妇被弄到喷水在线观看 | 亚洲国产欧美一区点击进入| 国产999久久高清免费观看| 国产熟人av一二三区| 国精产品一二三区传媒公司| 日韩av在线观看免费| 成人a片产无码免费视频在线观看| 精品免费国产一区二区三区四区介绍| 黑人巨大精品欧美一区二区| 国产又猛又黄又爽| 免费无码作爱视频| 女人被爽到呻吟gif动态图视看 | 国产又大又粗又爽的毛片| 亚洲成a人片在线播放| 日韩中文字幕在线专区| 国产精品爽爽v在线观看无码| 日本成本人片视频免费| 久久精品国产只有精品66| 大胆欧美熟妇xx| 成年女人18级毛片毛片免费| 无遮挡十八禁污污网站免费| 五月婷婷久久草| 亚洲永久无码7777kkk| 欧美精品18videosex性欧美| 日本少妇内射视频播放舔| 国产精品无码午夜福利| 国产精品a成v人在线播放| 被c到高潮疯狂喷水国产|