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Recombinant Human Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 (B3GAT1), partial

  • 中文名稱:
    Recombinant Human Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1(B3GAT1),partial
  • 貨號(hào):
    CSB-YP873741HU
  • 規(guī)格:
  • 來(lái)源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1(B3GAT1),partial
  • 貨號(hào):
    CSB-EP873741HU
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Human Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1(B3GAT1),partial
  • 貨號(hào):
    CSB-EP873741HU-B
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1(B3GAT1),partial
  • 貨號(hào):
    CSB-BP873741HU
  • 規(guī)格:
  • 來(lái)源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1(B3GAT1),partial
  • 貨號(hào):
    CSB-MP873741HU
  • 規(guī)格:
  • 來(lái)源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    B3GAT1
  • Uniprot No.:
  • 別名:
    3-glucuronyltransferase 1; 3-glucuronyltransferase; B3GA1_HUMAN; B3gat1; Beta 1 3 glucuronyltransferase 1; Beta-1; Beta-1,3-glucuronyltransferase 1; CD 57; CD57; CD57 antigen; Galactosylgalactosylxylosylprotein 3 beta glucuronosyltransferase 1; Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1; GlcAT P; GlcAT-P; GLCATP; GlcUAT P; GlcUAT-P; GlcUATP; Glucuronosyltransferase P; HNK 1; HNK1; LEU 7; LEU7; LEU7 antigen; NK 1; NK1; UDP GlcUA glycoprotein beta 1 3 glucuronyltransferase; UDP-GlcUA:glycoprotein beta-1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度:
    Partial
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group.
  • 基因功能參考文獻(xiàn):
    1. Cellular levels of HNK-1 carrier glycoforms are decreased in the brain of Alzheimer's disease subjects. PMID: 26738850
    2. CD4(+) T cells that coexpress CD57 and CD154, which are exclusively present in cytomegalovirus-positive individuals. PMID: 27566833
    3. greater HIV RNA transcription was associated with lower CD57 expression on CD8 T cells. Although causality cannot be inferred from this retrospective study, these results suggest that asymptomatic CMV replication and residual cellular HIV transcription may contribute to persistent immune dysregulation during suppressive ART. PMID: 26818740
    4. TRAF4 expression is higher in mastocytosis patients with food hypersensitivity in their medical history, while B3GAT1 expression is lower in mastocytosis patients with insect venom allergy in history PMID: 27086366
    5. analysis of natural killer cell markers in renal transplantation that have roles in acute rejection reveals that CD56 and CD57 are increased in the interstitial compartment in donor-specific antibody (DSA)-negative biopsies from patients with acute antibody-mediated rejection without C4d, and CD16 is increased in the glomerular compartment in DSA-positive biopsies PMID: 26615051
    6. Case Report: chronic lymphocytic leukemia with aberrant CD56 and CD57 expression. PMID: 26013700
    7. Among CD8+ T-lymphocytes, CD28+CD57+ cells represent a subset with some senescent features that are distinct from the CD28-CD57+ cells. PMID: 26277688
    8. analysis of CD57 in prostate neoplasms and benign prostatic tissue PMID: 24977150
    9. The frequency of CD57-expressing antigen specific CD4+ T cells was higher in active compared to latent tuberculosis. PMID: 25931385
    10. glioblastoma stem cells are killed by CD133-specific CAR T cells but induce the T cell aging marker CD57 PMID: 25426558
    11. polyfunctional CD57+ cell expansion has a role in CD8+ T cell response to Staphylococcal Enterotoxin B during CMV latent infection PMID: 24533103
    12. Our results suggest that an increase in the population of CD57(+) T-cells is a potent prognostic marker and may also influence the systemic immunity of patients with OSCC. PMID: 25275081
    13. Abnormally low proportions of CD28(-)CD8(+) T cells expressing CD57 predict increased mortality during treated HIV infection and may be reversed with early ART initiation. PMID: 24585893
    14. NKG2C(hi)CD57+ NK cells respond specifically to acute infection with cytomegalovirus and not Epstein-Barr virus. PMID: 24740502
    15. CD56dim CD57int NK cells represent an intermediate functional phenotype in response to vaccine-induced and receptor-mediated stimuli. PMID: 24843874
    16. T cells in unaffected skin from psoriasis patients exhibit a phenotype compatible with replicative inability. As they have a lower replicative capacity, CD57+ T cells are less frequent in lesional tissue due to the high cellular turnover. PMID: 23468834
    17. NKG2Chi CD57hi natural killer cells are highly responsive to human cytomegalovirus-infected macrophages only in the presence of HCMV-specific antibodies, whereas they are functionally poor effectors of natural cytotoxicity. PMID: 23637420
    18. Analysis identified CD57(bright) expression as a reliable phenotype of granule marker-containing cytotoxic T-lymphocytes. PMID: 23287865
    19. Strong expression of CD57 correlates with aggressive attributes of U-NB1 and SK-N-BE(2)-C neuroblastoma cells and is linked with undifferentiated neuroblastoma cells in patients. PMID: 22900004
    20. HIV infected subjects had higher percentage of T cell subsets expressing CD57. PMID: 22310831
    21. CD57+ cells may be involved in chronic obstructive pulmonary disease pathogenesis, especially in the most severe stages of the disease. PMID: 22127595
    22. 33 directly measured and 13 derived glycosylation traits in 3533 individuals were identified and three novel gene association (MGAT5, B3GAT1 and SLC9A9) were identified using an additional European cohort. PMID: 21908519
    23. an increase in CD4+CD57+ T cells controls the capability of PB to produce the anti-tumor cytokine IFN-gamma and PB-IFN-gamma production is impaired with HCC tumor progression PMID: 21491089
    24. The donor HNK1 haplotype is associated with better clinical outcome among recipients, with standard-risk disease, of bone marrow transplants from HLA-matched unrelated donors. PMID: 19794085
    25. The density of CD57+ cells within lymphoid follicles of chronic obstructive pulmonary disease patients was significantly increased compared to that of nonsmokers and smokers without chronic obstructive pulmonary disease. PMID: 20525712
    26. Lung biopsies from idiopathic pulmonary fibrosis showed upregulation of GlcAT-I, a rate-limiting enzyme in GAG synthesis. PMID: 21056957
    27. assessed the transcriptional, phenotypic, and functional differences between CD57(+) and CD57(-) NK cells within the CD56(dim) mature NK subset PMID: 20733159
    28. CD56(dim) NK cells continue to differentiate. During this process, they lose expression of NKG2A, sequentially acquire inhibitory killer cell inhibitory immunoglobulin-like receptors and CD57. PMID: 20696944
    29. Protein-bound polysaccharide K improves overall survival of stage III gastric cancer patients partly by inhibiting CD57(+) T cells. PMID: 20229169
    30. substrate specificity toward UDP-glucuronic acid determined by two crucial histidine and arginine residues PMID: 11986319
    31. Expression of CD57 defines replicative senescence and HIV antigen-induced apoptotic death of CD8+ T cells, and CD57 may be involved in apoptosis and lack of proliferation. PMID: 12433688
    32. differences in CgA and CD57 expression in human neuroendocrine tumors are related to the degree of differentiation of the neoplasms and probably reflect the degree of maturation (functional state) of neuroendocrine granules within the neoplastic cells. PMID: 12687271
    33. Polymorphic or other variation of the 11q telomere may affect the activity of B3GAT1 and be a risk factor for schizophrenia and related psychoses in the general population. PMID: 12874601
    34. CD57 has a role in antitumor immunity which is impaired in gastric cancer PMID: 12883721
    35. GlcAT-P is an enzyme critical in the biosynthesis of the carbohydrate epitope HNK-1 PMID: 14993226
    36. first pediatric case describing coexpression of CD57 on B-lineage acute lymphoblastic leukemia PMID: 15626024
    37. CD8-positive T cells expressing CD57, a marker of replicative senescence, also express killer cell lectin-like receptor G1 (KLRG1); however, a population of CD57-negative KLRG1+ cells is also identified. This population may represent a "memory" phenotype. PMID: 15879103
    38. It was found that collagen type IX and HNK-1 epitope were present in tears, the amount of the former being increased 2.7 times compared to normal. PMID: 16257185
    39. study identifies GlcAT-I as a target of calcium-dependent signaling pathway and evidences the critical role of Sp1 transcription factor in the activation of GlcAT-I expression PMID: 16807373
    40. CD8+CD57+ T cells are a subset of effector cells that could be helpful to evaluate the cell-mediated immune response to Mycobacterium tuberculosis PMID: 17035093
    41. data suggest that the expression of CD30 and CD57 cell markers on T cells could reflect circulating effector T cell early activation in the allergic airway disease. PMID: 18201430
    42. ability of CD8hi CD57+ T cells to further differentiate is highlighted by a distinct cytokine profile late after activation that includes the unexpected release of high levels of interleukin PMID: 18383036
    43. Overexpression of HNK-1 is associated with metastasis in melanoma. PMID: 18802400
    44. CD57 was linked to higher apoptosis resistance in CD8(+) T cells in HIV infection. PMID: 19564339

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  • 亞細(xì)胞定位:
    [Isoform 1]: Golgi apparatus membrane; Single-pass type II membrane protein. Secreted.; [Isoform 2]: Golgi apparatus membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane. Secreted.
  • 蛋白家族:
    Glycosyltransferase 43 family
  • 組織特異性:
    Mainly expressed in the brain.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 921

    OMIM: 151290

    KEGG: hsa:27087

    STRING: 9606.ENSP00000307875

    UniGene: Hs.381050



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