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  4. Recombinant Human GA-binding protein alpha chain (GABPA E4TF1A)

Recombinant Human GA-binding protein alpha chain (GABPA E4TF1A)

  • 中文名稱：
  • 貨號：
    CSB-YP2276HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
  • 貨號：
    CSB-EP2276HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
  • 貨號：
    CSB-EP2276HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
  • 貨號：
    CSB-BP2276HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
  • 貨號：
    CSB-MP2276HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    GA-binding protein alpha chain; GABP subunit alpha; Nuclear respiratory factor 2 subunit alpha; Transcription factor E4TF1-60; GABPA E4TF1A
  • 種屬：
    Homo sapiens (Human)
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene.
  • 基因功能參考文獻：
    1. Data indicate the essential role of the GABP transcription factor in activating translocase of inner mitochondrial membrane 23 TIMM23 and TIMM23B expression. PMID: 29413900
    2. Collectively, our data indicate that GABPA inhibits hepatocellular carcinoma cell migration and could serve as a novel biomarker for prognosis PMID: 28549418
    3. CRISPR-mediated reversal of mutant TERT promoters, or deletion of its long-range interacting chromatin, abrogates GABPA binding and long-range interactions, leading to depletion of active histone marks, loss of POL2 recruitment, and suppression of TERT transcription PMID: 27650951
    4. potential mechanism of TERT reactivation mediated by a novel long-range chromatin interaction between the TERT promoter on chromosome 5p and a 300-kb upstream region. This permits recruitment of the transcription factor GABPA in mutant TERT promoters but not in wild-type promoters. PMID: 27807101
    5. a key role for GABPA/B1 as the critical ETS transcription factors deregulating SDHD expression in the context of highly recurrent promoter mutations in melanoma. PMID: 28108517
    6. Analyses of data sets link GABPa to cognitive disorders, diabetes, KRAB zinc finger (KRAB-ZNF), and human-specific genes. PMID: 26814189
    7. ELF1 binding occurs at both TERT promoter mutations in melanoma in vitro such that increased recruitment of GABP is enabled by the spatial architecture of native and novel ETS motifs in the TERT promoter region. PMID: 26553150
    8. The results suggest that NRF-2alpha is a regulator of SIRT3 expression and may shed light on how SIRT3 is upregulated during nutrient stress. PMID: 26109058
    9. GABPalpha Binding to Overlapping ETS and CRE DNA Motifs Is Enhanced by CREB1 PMID: 26185160
    10. study supports the crucial role of GABP in myeloid cell differentiation and identified ITGAM/CD11b as a novel GABP target gene PMID: 26170143
    11. GABPA thus directly links TERT promoter mutations to aberrant expression in multiple cancers. PMID: 25977370
    12. GABPA exhibits an increase in binding signal with higher numbers of ETS motifs per promoter. Analysis of the distance between inverted pairs of ETS motifs within promoters and binding by p53, ETS1 and GABPA, shows a coordination of binding for the 3. PMID: 24481480
    13. results demonstrate the functional importance of the C/EBPalpha C-terminus beyond the bZIP DNA-binding and dimerization region, which may mediate cooperative activation by C/EBPalpha and GABP of myeloid-specific genes PMID: 24076158
    14. GABP alpha is required for YAP expression in vitro and in vivo, and that YAP is an important effector downstream of GABP for cell survival and cell-cycle progression. PMID: 23684612
    15. When NRF-2alpha and NRF-2beta form a complex, the nuclear import of NRF-2alphabeta becomes strictly dependent on the nuclear localization signal within NRF-2beta. PMID: 23856623
    16. Results suggest that the NRF-2 A/C polymorphism is associated with endurance performance at the elite level in a Spanish population. PMID: 22749526
    17. although ELK1 and GABPA ultimately control the same biological process, they do so by regulating different cohorts of target genes associated with cytoskeletal functions and cell migration contro PMID: 23284628
    18. The phenotype is best uniformly termed congenital cone-rod synaptic disorder. In Saudi Arabia a founder homozygous c.81_82insA CABP4 mutation is a recurrent cause. PMID: 23099293
    19. expression of NRF-2alpha in hepatocellular carcinoma (HCC) and tumor-adjacent specimens; higher-grade frequency of expression of NRF-2alpha in tumor-adjacent tissues was higher than tumor tissues, suggesting NRF-2alpha may play important role in carcinogenesis of HCC PMID: 20127517
    20. Hepatoprotection of quercetin against oxidative stress by induction of metallothionein expression through activating MAPK and PI3K pathways and enhancing Nrf2 DNA-binding activity. PMID: 21624509
    21. an Nrf2-dependent response to exogenous stimuli may affect annual FEV1 decline PMID: 21774808
    22. NRF2 A/C and NRF2 C/T single nucleotide polymorphisms (SNPs) are associated, separately and in combination, with elite endurance athletes. PMID: 20028934
    23. Data show that NRF2 binds to the proximal promoter region of the genes coding for the mTERF, POLRMT, the B subunit of the DNA polymerase-gamma, TWINKLE, and the single-stranded DNA-binding protein mtSSB. PMID: 19951946
    24. Data show that a significant overlaps between the ELK1- and SRF-binding regions, and between ELK1- and GABPA-binding regions. PMID: 19687146
    25. GABP is essential for the regulation of IL-7Ralpha expression in T cells. PMID: 15361867
    26. there is a physical interaction between the GABPalpha subunit and C/EBPalpha PMID: 15928042
    27. TRAP220/MED1 plays a novel coregulatory role in facilitating the recruitment of TRAP/Mediator to specific target genes involved in growth and cell cycle progression via GABP PMID: 16574658
    28. GABPA and p300 are essential components of retinoic acid-induced enhanceosome in myeloid cells. PMID: 16581781
    29. NRF-2 may play a key role in the regulation of mitochondrial protein synthesis in a cell line. PMID: 17161026
    30. Upon activation of AChR, GABP recruits the histone acetyl transferase (HAT) p300 on the AChR epsilon subunit promoter, whereas it rather recruits the histone deacetylase HDAC1 when the promoter is not activated. PMID: 17304221
    31. These findings demonstrate that GABP regulates the majority of divergent promoters and suggest that bidirectional transcriptional activity is mediated through GABP binding and transactivation at both divergent and nondivergent promoters. PMID: 18020712
    32. nuclear respiratory factor-2 binding site methylation suppresses the promoter activity of the human TOMM70 gene PMID: 18852034
    33. ILF-3, which has been known to regulate IL-2 expression in T cells, up-regulates synoviolin expression with GABPalpha in rheumatoid synovial cells PMID: 19116932
    34. study identified a decrease in a transcription factor complex containing NRF-2 in nuclear extracts from multiple sclerosis cortex; decrease correlates with decreased expression of electron transport chain subunit genes & increased oxidative damage PMID: 19187944
    35. The intronic DNase I-hypersensitive sites element acts in cis to maintain transcriptional competency at the TMS1 locus and that this activity is mediated by the ets transcription factor, GABPalpha. PMID: 19324871

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    ETS family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 4071

    OMIM: 600609

    KEGG: hsa:2551

    STRING: 9606.ENSP00000346886

    UniGene: Hs.473470



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