在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Fructosamine-3-kinase (FN3K)

Recombinant Human Fructosamine-3-kinase (FN3K)

  • 中文名稱：
    人FN3K重組蛋白
  • 貨號：
    CSB-YP872493HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人FN3K重組蛋白
  • 貨號：
    CSB-EP872493HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人FN3K重組蛋白
  • 貨號：
    CSB-EP872493HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人FN3K重組蛋白
  • 貨號：
    CSB-BP872493HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人FN3K重組蛋白
  • 貨號：
    CSB-MP872493HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    FN3K
  • Uniprot No.：
  • 別名：
    FN3KFructosamine-3-kinase; EC 2.7.1.171; Protein-psicosamine 3-kinase FN3K; Protein-ribulosamine 3-kinase FN3K; EC 2.7.1.172
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-309
  • 氨基酸序列
    MEQLLRAELR TATLRAFGGP GAGCISEGRA YDTDAGPVFV KVNRRTQARQ MFEGEVASLE ALRSTGLVRV PRPMKVIDLP GGGAAFVMEH LKMKSLSSQA SKLGEQMADL HLYNQKLREK LKEEENTVGR RGEGAEPQYV DKFGFHTVTC CGFIPQVNEW QDDWPTFFAR HRLQAQLDLI EKDYADREAR ELWSRLQVKI PDLFCGLEIV PALLHGDLWS GNVAEDDVGP IIYDPASFYG HSEFELAIAL MFGGFPRSFF TAYHRKIPKA PGFDQRLLLY QLFNYLNHWN HFGREYRSPS LGTMRRLLK
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate. Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions. Involved in intracellular deglycation in erythrocytes. Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function. Also able to phosphorylate psicosamines and ribulosamines.
  • 基因功能參考文獻：
    1. In a multiple regression analysis, FN3K rs1056534, TF polymorphism and presence of diabetes mellitus were predictors for HHV-8 infection. PMID: 27461879
    2. FN3K could act in concert with other molecular mechanisms and may impact on gene expression and activity of other enzymes involved in deglycation process PMID: 26352355
    3. Report association of rs1056534 and rs3848403 of fructosamine 3-kinase gene with sRAGE in patients with diabetes. PMID: 24908234
    4. The marginal association of rs1056534 of FN3K is located in exon 6 with diabetic nephropathy progression. PMID: 23492569
    5. two new mutations and additional variants within the FN3K gene in diabetic patients PMID: 21288167
    6. These findings suggest that deglycating enzymes Glyoxalase I and fructosamine-3-kinase may be involved in the malignant transformation of colon mucosa. PMID: 21253391
    7. G900C polymorphism associates with the level of HbA (1c) and the onset of type 2 diabetes mellitus, but not with either of the diabetic microvascular complications. PMID: 19834870
    8. involved in the removal of fructosamine residues from hemoglobin in erythrocytes. PMID: 11975663
    9. The aim of this work was to identify the fructosamine residues on hemoglobin that are removed as a result of the action of FN3K in intact erythrocytes. PMID: 15102834
    10. These data suggest that FN3K and FN3KRP act as protein repair enzymes and are expressed constitutively in human cells independently of some of the variables altered in the diabetic state. PMID: 15381090
    11. Enzyme is a constitutive "housekeeping" gene and that ig plays an important role in cell metabolism, possibly as a deglycating enzyme. PMID: 16037310
    12. No significant correlation between FN3K activity and the levels of HbA1c, total glycated haemoglobin (GHb) and haemoglobin fructoselysine residues, either in the normoglycaemic or diabetic group. PMID: 16523184
    13. In this paper we propose a resolution of both these quandaries by proposing that fructosamine-6-phosphates are deglycated by phosphorylation to fructosamine-3,6-bisphosphates catalyzed by FN3KRP and/or possibly FN3K. PMID: 16920277

    顯示更多

    收起更多

  • 蛋白家族：
    Fructosamine kinase family
  • 組織特異性：
    Widely expressed. Expressed in erythrocytes.
  • 數據庫鏈接：

    HGNC: 24822

    OMIM: 608425

    KEGG: hsa:64122

    STRING: 9606.ENSP00000300784

    UniGene: Hs.151135



主站蜘蛛池模板： 乱人伦中文字幕成人网站在线| 成人片黄网站色大片免费| 99精品一区二区三区无码吞精| 国产精品亚洲一区二区三区| 国产成人一区二区精品视频| 国产av久久人人澡人人爱| 亚洲精品成人网站在线播放| 无码三级中文字幕在线观看| 国产初高中生真实在线视频| 国产乱色国产精品播放视频 | 黑人粗硬进入过程视频| 天堂va蜜桃一区二区三区| 国产亚洲中文日本不卡二区| 日本黄漫动漫在线观看视频| 亚洲乱码中文字幕手机在线| 久久国产精品无码网站| 轻点好疼好大好爽视频| 亚洲精品久久久久久下一站| 亚洲精品久久久无码av片软件| 日韩国产精品人妻无码久久久| 国模雨珍浓密毛大尺度150p| 中文字幕精品亚洲无线码一区| 国产成人精品日本亚洲77上位| 国产成人综合在线女婷五月99播放| 一边做一边喷17p亚洲乱妇50p| 国产精品久久久久久久久绿色| 深夜福利视频在线播放| 日韩人妻精品一区二区三区视频 | 私人家庭影院5777| 99亚洲乱人伦aⅴ精品| 欧美人与动性xxxxx杂性| 欲香欲色天天天综合和网| 十八禁真人啪啪免费网站| 无码日韩人妻av一区免费 | 亚洲国产成人久久一区久久| 一卡二卡3卡四卡网站精品| 国产佗精品一区二区三区| 国产免国产免费| 国产片精品av在线观看夜色| 亚洲国产码专区| 亚洲精品无码专区|