在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Fructosamine-3-kinase (FN3K)

  • 中文名稱:
    人FN3K重組蛋白
  • 貨號:
    CSB-YP872493HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人FN3K重組蛋白
  • 貨號:
    CSB-EP872493HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人FN3K重組蛋白
  • 貨號:
    CSB-EP872493HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人FN3K重組蛋白
  • 貨號:
    CSB-BP872493HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人FN3K重組蛋白
  • 貨號:
    CSB-MP872493HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    FN3K
  • Uniprot No.:
  • 別名:
    FN3KFructosamine-3-kinase; EC 2.7.1.171; Protein-psicosamine 3-kinase FN3K; Protein-ribulosamine 3-kinase FN3K; EC 2.7.1.172
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-309
  • 氨基酸序列
    MEQLLRAELR TATLRAFGGP GAGCISEGRA YDTDAGPVFV KVNRRTQARQ MFEGEVASLE ALRSTGLVRV PRPMKVIDLP GGGAAFVMEH LKMKSLSSQA SKLGEQMADL HLYNQKLREK LKEEENTVGR RGEGAEPQYV DKFGFHTVTC CGFIPQVNEW QDDWPTFFAR HRLQAQLDLI EKDYADREAR ELWSRLQVKI PDLFCGLEIV PALLHGDLWS GNVAEDDVGP IIYDPASFYG HSEFELAIAL MFGGFPRSFF TAYHRKIPKA PGFDQRLLLY QLFNYLNHWN HFGREYRSPS LGTMRRLLK
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate. Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions. Involved in intracellular deglycation in erythrocytes. Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function. Also able to phosphorylate psicosamines and ribulosamines.
  • 基因功能參考文獻:
    1. In a multiple regression analysis, FN3K rs1056534, TF polymorphism and presence of diabetes mellitus were predictors for HHV-8 infection. PMID: 27461879
    2. FN3K could act in concert with other molecular mechanisms and may impact on gene expression and activity of other enzymes involved in deglycation process PMID: 26352355
    3. Report association of rs1056534 and rs3848403 of fructosamine 3-kinase gene with sRAGE in patients with diabetes. PMID: 24908234
    4. The marginal association of rs1056534 of FN3K is located in exon 6 with diabetic nephropathy progression. PMID: 23492569
    5. two new mutations and additional variants within the FN3K gene in diabetic patients PMID: 21288167
    6. These findings suggest that deglycating enzymes Glyoxalase I and fructosamine-3-kinase may be involved in the malignant transformation of colon mucosa. PMID: 21253391
    7. G900C polymorphism associates with the level of HbA (1c) and the onset of type 2 diabetes mellitus, but not with either of the diabetic microvascular complications. PMID: 19834870
    8. involved in the removal of fructosamine residues from hemoglobin in erythrocytes. PMID: 11975663
    9. The aim of this work was to identify the fructosamine residues on hemoglobin that are removed as a result of the action of FN3K in intact erythrocytes. PMID: 15102834
    10. These data suggest that FN3K and FN3KRP act as protein repair enzymes and are expressed constitutively in human cells independently of some of the variables altered in the diabetic state. PMID: 15381090
    11. Enzyme is a constitutive "housekeeping" gene and that ig plays an important role in cell metabolism, possibly as a deglycating enzyme. PMID: 16037310
    12. No significant correlation between FN3K activity and the levels of HbA1c, total glycated haemoglobin (GHb) and haemoglobin fructoselysine residues, either in the normoglycaemic or diabetic group. PMID: 16523184
    13. In this paper we propose a resolution of both these quandaries by proposing that fructosamine-6-phosphates are deglycated by phosphorylation to fructosamine-3,6-bisphosphates catalyzed by FN3KRP and/or possibly FN3K. PMID: 16920277

    顯示更多

    收起更多

  • 蛋白家族:
    Fructosamine kinase family
  • 組織特異性:
    Widely expressed. Expressed in erythrocytes.
  • 數據庫鏈接:

    HGNC: 24822

    OMIM: 608425

    KEGG: hsa:64122

    STRING: 9606.ENSP00000300784

    UniGene: Hs.151135



主站蜘蛛池模板: 欧美大浪妇猛交饥渴大叫| 无码爆乳护士让我爽| 中国内地毛片免费高清| 亚洲乱码国产乱码精品精大量 | 啊轻点内射在线视频| 99热国产这里只有精品6| 无码人妻h动漫| 丰满岳乱妇在线观看中字无码 | 菠萝菠萝蜜午夜视频在线播放观看| 高清无码爆乳潮喷在线观看| 精品亚洲成a人在线观看| 精品国产黑色丝袜高跟鞋| 水蜜桃精品一二三| 亚洲欧美日韩另类精品一区| 无码国产精品一区二区色情男同| 色婷婷久久久swag精品| 亚洲高潮喷水无码av电影| 在线成人爽a毛片免费软件| 国产成人精品优优av| 久久久综合九色综合88| 熟妇无码熟妇毛片| 亚洲色一区二区三区四区| 成人av片无码免费网站| 久99视频精品免费观看福利| 蜜桃mv在线播放免费观看视频| 欧美精品高清在线观看| 亚洲精品久久久一二三区| 在线精品视频一区二区三四 | 日本丰满护士videossexhd| 国产午夜片无码区在线播放| 护士的小嫩嫩好紧好爽| 热の综合热の国产热の潮在线| 99re6这里有精品热视频| 人妻人人做人做人人爱| 久久精品国产999久久久| 九九九精品成人免费视频小说| 久久精品国产免费观看| 色欲αv一区二区三区天美传媒| 最美女人体内射精一区二区| 中文字幕丰满孑伦无码专区| 日韩精品无码一本二本三本|