在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Formin-binding protein 1-like (FNBP1L)

Recombinant Human Formin-binding protein 1-like (FNBP1L)

  • 中文名稱：
    人FNBP1L重組蛋白
  • 貨號：
    CSB-YP722560HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人FNBP1L重組蛋白
  • 貨號：
    CSB-EP722560HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人FNBP1L重組蛋白
  • 貨號：
    CSB-EP722560HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人FNBP1L重組蛋白
  • 貨號：
    CSB-BP722560HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人FNBP1L重組蛋白
  • 貨號：
    CSB-MP722560HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    FNBP1L
  • Uniprot No.：
  • 別名：
    C1orf39; FBP1L_HUMAN; FNBP 1L; fnbp1l; Formin binding protein 1 like; Formin-binding protein 1-like; TOCA 1; Toca-1; TOCA1; Transducer of Cdc42 dependent actin assembly 1; Transducer of Cdc42 dependent actin assembly protein 1; Transducer of Cdc42-dependent actin assembly protein 1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-605
  • 氨基酸序列
    MSWGTELWDQ FDSLDKHTQW GIDFLERYAK FVKERIEIEQ NYAKQLRNLV KKYCPKRSSK DEEPRFTSCV AFFNILNELN DYAGQREVVA EEMAHRVYGE LMRYAHDLKT ERKMHLQEGR KAQQYLDMCW KQMDNSKKKF ERECREAEKA QQSYERLDND TNATKADVEK AKQQLNLRTH MADENKNEYA AQLQNFNGEQ HKHFYVVIPQ IYKQLQEMDE RRTIKLSECY RGFADSERKV IPIISKCLEG MILAAKSVDE RRDSQMVVDS FKSGFEPPGD FPFEDYSQHI YRTISDGTIS ASKQESGKMD AKTTVGKAKG KLWLFGKKPK PQSPPLTPTS LFTSSTPNGS QFLTFSIEPV HYCMNEIKTG KPRIPSFRSL KRGVSLIMGP ALEDFSHLPP EQRRKKLQQR IDELNRELQK ESDQKDALNK MKDVYEKNPQ MGDPGSLQPK LAETMNNIDR LRMEIHKNEA WLSEVEGKTG GRGDRRHSSD INHLVTQGRE SPEGSYTDDA NQEVRGPPQQ HGHHNEFDDE FEDDDPLPAI GHCKAIYPFD GHNEGTLAMK EGEVLYIIEE DKGDGWTRAR RQNGEEGYVP TSYIDVTLEK NSKGS
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens.
  • 基因功能參考文獻：
    1. This suggests that TOCA1 binding to Cdc42 is an early step in the Cdc42-dependent pathways that govern actin dynamics, and the differential binding affinities of the effectors facilitate a handover from TOCA1 to N-WASP, which can then drive recruitment of the actin-modifying machinery. PMID: 27129201
    2. Loss of p53 tumor suppressor function in breast cancers leads to upregulation of Toca-1, and results in enhanced risk of developing metastatic disease. PMID: 25547174
    3. GWAS results show that the aggregate effects of common SNPs explain 22-46% of phenotypic variation in childhood intelligence in the three largest cohorts; FNBP1L was also significantly associated with childhood intelligence PMID: 23358156
    4. findings suggest that Toca-1 functions at an early step in the dissemination of metastatic breast tumor cells; taken together, results identify Toca-1 as a proinvasive protein in breast adenocarcinoma PMID: 22824798
    5. Toca-1 knockdown cells also display a significant defect in EGF-induced motility and invasiveness. PMID: 21062739
    6. Cdc42 may influence endocytic membrane trafficking by regulating the formation and activity of the Toca-1/N-WASP complex. PMID: 20730103
    7. Toca-1 promotes actin nucleation by activating the N-WASP-WIP/CR16 complex, the predominant form of N-WASP in cells. PMID: 15260990
    8. a vesicle trafficking regulator Toca-1 regulates different aspects of neuronal morphology from N-WASP PMID: 16885158
    9. We show that actin tail initiation by S. flexneri requires Toca-1 for the conversion of N-WASP from a closed inactive conformation to an open active one. PMID: 18191793
    10. the Toca-1-N-WASP complex can link filopodial formation to endocytosis PMID: 19213734
    11. FNBP1L appears dispensable for other forms of autophagy induced by serum starvation or rapamycin PMID: 19342671
    12. Human FNBP1L binds the autophagy protein Atg3 and is required for autophagy of Salmonella Typhimurium in epithelial cells PMID: 19342671

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cytoplasmic vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族：
    FNBP1 family
  • 數據庫鏈接：

    HGNC: 20851

    OMIM: 608848

    KEGG: hsa:54874

    STRING: 9606.ENSP00000271234

    UniGene: Hs.134060



主站蜘蛛池模板： 日本高清二区视频久二区| 国产乱码免费卡1卡二卡3| 国产婷婷精品av在线| 精品国产日韩亚洲一区| 日韩电影一区二区三区| 色先锋av影音先锋在线| 大肉大捧一进一出视频出来呀| 任我橹这里只有精品 在线视频| 日本另类αv欧美另类aⅴ| 狠狠综合久久av一区二区| 99er国产这里只有精品视频免费| 天天综合网亚在线| 国产亚洲精品久久久久久老妇小说| 中出内射颜射骚妇| 97人妻无码一区二区精品免费| 国产福利萌白酱精品一区| 亚洲老熟女av一区二区在线播放| 婷婷四房播播| 精品国内自产拍在线播放观看 | 国产一区二区不卡老阿姨| 加勒比无码人妻东京热| 亚洲a∨精品无码一区二区| 免费无码一区二区三区蜜桃| 中文字幕日本人妻久久久免费| 精品国精品国产自在久国产不卡 | 国产97在线 | 亚洲| 免费国产午夜理论片不卡| 亚洲国产aⅴ综合网| 国产一区二区三区美女| 亚洲爆乳无码一区二区三区| 欧美综合自拍亚洲图久青草| 欧美人妻少妇精品久久黑人 | 人妻少妇熟女javhd| 久久久久久综合网天天| 2020国产欧洲精品网站| 国内乱码一线二线三线| 国产真实夫妇视频| 狠狠做深爱婷婷久久综合一区| 色哟哟免费视频播放网站| 国产免费又色又爽粗视频| 未满十八18禁止免费无码网站|