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  4. Recombinant Human Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (GCNT1 NACGT2)

Recombinant Human Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (GCNT1 NACGT2)

  • 中文名稱：
  • 貨號：
    CSB-YP577163HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
  • 貨號：
    CSB-EP577163HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
  • 貨號：
    CSB-EP577163HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
  • 貨號：
    CSB-BP577163HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
  • 貨號：
    CSB-MP577163HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    GCNT1
  • Uniprot No.：
  • 別名：
    Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase; EC 2.4.1.102; Core 2 beta-1,6-N-acetylglucosaminyltransferase; C2GlcNAcT; Core 2-branching enzyme; Core2-GlcNAc-transferase; C2GNT; Core 2 GNT; Leukocyte type core 2 beta-1,6-N-acetylglucosaminyltransferase; C2GnT-L; GCNT1 NACGT2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Glycosyltransferase that catalyzes the transfer of an N-acetylglucosamine moiety onto mucin-type core 1 O-glycan to form the branched mucin-type core 2 O-glycan. Mucin-type core 2 O-glycans play an important role in leukocyte extravasation as they serve as scaffolds for the display of the selectin ligand sialyl Lewis X by leukocytes.
  • 基因功能參考文獻：
    1. GCNT1 expression in prostate biopsy specimen is a significant and independent predictor of recurrence after radical prostatectomy, which can be used in pre-treatment decision making for the patient. PMID: 26768364
    2. GCNT1 expression in prostate cancer positively correlates with cancer progression and prostate-specific antigen recurrence. PMID: 26390303
    3. Results show that ST3Gal1 uses GM130-GRASP65 and giantin, whereas C2GnT-L uses only giantin for Golgi targeting and defective giantin dimerization in PC-3 and DU145 prostate cancer cells causes fragmentation of the Golgi and prevents its targeting. PMID: 25086069
    4. NMIIA is the master regulator of Golgi fragmentation induced by heat shock or inhibition/depletion of HSP70/90 through interaction with gylosyltransferases. PMID: 23990450
    5. GCNT1 is over-expressed in prostate cancer and is associated with higher levels of core 2 O-sLe(x) in PSA, PAP and MUC1 proteins. PMID: 24854630
    6. Immunohistochemical expression of core 2 beta1,6-N-acetylglucosaminyl transferase 1 (C2GnT1) in endometrioid-type endometrial carcinoma may be a novel potential prognostic factor. PMID: 23617619
    7. C2GnT-expressing prostate cancer cells evade NK cell immunity and survive longer in the host blood circulation, thereby resulting in the promotion of prostate cancer metastasis. PMID: 23165940
    8. GOLPH3 can regulate cell-cell interaction by controlling Golgi retention of C2GnT1. PMID: 23027862
    9. Down-regulation of C2GnT1 is correlated with breast cancer PMID: 22534569
    10. The X-ray crystal structure (2.3 A resolution) of a mutant form of C2GnT-L (C217S) in complex with UDP was solved. C2GnT-L exists in an "open" conformation and a "closed" conformation. PMID: 22056345
    11. In C2GnT-expressing bladder tumour cells galectin-3 bound the NKG2D-binding site of MICA, reducing the affinity of MICA for NKG2D on natural killer cells and hence severely impairing natural killer cell activation. PMID: 21712812
    12. Data show that the reconstituted membrane system in cells expressing C2GnT-I led to the lipid vesicles exhibiting an enzyme activity 11 times higher than that found in microsomal membranes. PMID: 21081110
    13. Core2 O-glycan structure is essential for expression of SI and DDP-IV during intestinal cell differentiation. PMID: 20841351
    14. Overexpression of C2GnT-1 enhances the metastatic potential of testicular germ cell tumor. PMID: 20017138
    15. EGF suppressed C2GnT activity in a time- and dose-dependent fashion, and also suppressed core 4 beta1,6 N-acetylglucosaminyltransferase (C4GnT) activity PMID: 12600830
    16. presence of multiple tissue-specific promoters for the C2GnT I gene PMID: 12626388
    17. elevated glucose increases the activity of core 2 GlcNAc-T and adhesion of human leukocytes to retinal capillary endothelial cells, in a dose-dependent manner, through diabetes-activated serine/threonine protein kinase C beta2-dependent phosphorylation PMID: 12765965
    18. core 2 beta1-6-N-glucosaminyltransferase and dimerization of P-selectin glycoprotein ligand-1 have roles in rolling on P-selectin PMID: 15026421
    19. C2GnT-1 regulates sLeX expression level during differentiation of pre-B cells PMID: 15483269
    20. upregulated by all-trans retinoic acid (RA) and by IL-4 and IL-13 in the H292 airway epithelial cell line PMID: 15591039
    21. A/G polymorphism in enzyme is associated with the susceptibility to prostate cancer in a Japanese population PMID: 15882971
    22. Core2GnT is an extremely useful prognostic marker for prostate cancer progression. Acquiring Core2GnT in prostate carcinoma cells facilitates adhesion to type IV collagen and laminin causing aggressive tumor formation by prostate cancer cells. PMID: 15932919
    23. C2GnT-1 regulates selectin ligand expression; downregulation of the selectin ligand expression level inhibits tissue infiltration of BCP-leukemia cells PMID: 16179912
    24. glycosyltransferase haploinsufficiency results in altered cellular glycosylation and resistance to cell death, identifying a new survival mechanism for T-lymphoma cells PMID: 16778138
    25. 2 beta1,6 N-acetylglucosaminyltransferase-I transcription is regulated by Sp1 in lymphocytes and epithelial cells PMID: 17530395
    26. regulation of O-glycosylation controls sLe(x) expression, and also suggest that O-glycans may have a function in dendritic cells migration PMID: 17947642
    27. Pancreas carcinoma antigen, C2GnT, fused to invariant chain elicits T-cell response and tumor growth inhibition. PMID: 18815556
    28. 15-fold increase in C2GnT1 mRNA levels in colorectal adenocarcinomas compared to normal colorectal tissues PMID: 19267921
    29. Data show that a short glycopeptide Galbeta1-3GalNAcalpha-TAGV was identified as an efficient C2GnT substrate. PMID: 19524017

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  • 亞細胞定位：
    Golgi apparatus membrane; Single-pass type II membrane protein. Note=Also detected in the trans-Golgi network.
  • 蛋白家族：
    Glycosyltransferase 14 family
  • 組織特異性：
    Highly expressed in activated T-lymphocytes and myeloid cells.
  • 數據庫鏈接：

    HGNC: 4203

    OMIM: 600391

    KEGG: hsa:2650

    STRING: 9606.ENSP00000365920

    UniGene: Hs.521568



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