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  4. Recombinant Human Ferritin, mitochondrial (FTMT)

Recombinant Human Ferritin, mitochondrial (FTMT)

  • 中文名稱：
    人FTMT重組蛋白
  • 貨號：
    CSB-YP839796HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人FTMT重組蛋白
  • 貨號：
    CSB-EP839796HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人FTMT重組蛋白
  • 貨號：
    CSB-EP839796HU-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人FTMT重組蛋白
  • 貨號：
    CSB-BP839796HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人FTMT重組蛋白
  • 貨號：
    CSB-MP839796HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    FTMT
  • Uniprot No.：
  • 別名：
    FerH; Ferritin; Ferritin H subunit; Ferritin; mitochondrial; Fth 3; Fth3; FTMT; FTMT_HUMAN; mitochondrial; Mitochondrial ferritin; MTF; OTTHUMP00000159158
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區(qū)域：
    50-242
  • 氨基酸序列
    A AAASSRDPTG PAAGPSRVRQ NFHPDSEAAI NRQINLELYA SYVYLSMAYY FSRDDVALNN FSRYFLHQSR EETEHAEKLM RLQNQRGGRI RLQDIKKPEQ DDWESGLHAM ECALLLEKNV NQSLLELHAL ASDKGDPHLC DFLETYYLNE QVKSIKELGD HVHNLVKMGA PDAGLAEYLF DTHTLGNENK QN
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
  • 基因功能參考文獻：
    1. These results suggest that the elevation of expression levels of FTMT in the reticulocytes of patients with alpha-thalassaemia may be associated with iron loading and oxidative stress. PMID: 29993346
    2. Via activation of cAMP/PKA/CREB pathway and upregulation of the downstream FtMt expression. PMID: 30069985
    3. The expression of FTMT appears regulated by a complex mechanism involving epigenetic events and interplay between transcription factors. PMID: 27625068
    4. Age-related increase is found in FtMt and hypoxia-inducible factor-1a (HIF-1a) in murine retinal pigment epithelium (RPE).HIF-1alpha stabilization reduced the protein level of the mature, functional form of mitochondrial ferritin. PMID: 27599360
    5. Study characterized a new human FtMt antibody, and with it created the first map of FtMt immunoreactivity in a monkey brainstem. This showed the widespread distribution of FtMt in various brainstem regions and co-localization with catecholaminergic neurons. PMID: 27133573
    6. experimental overexpression of FTMT may modify mitochondrial iron availability and lead to ineffective erythropoiesis PMID: 23573868
    7. FtMt mutation may determine a condition similar to haploinsufficiency resulting in a reduced protection from iron-dependent oxidative stress in mitochondria PMID: 22706241
    8. Stat5-dependent transcriptional regulation is displaced by strong cytosolic iron starvation status induced by mitochondrial ferritin. PMID: 21712541
    9. higher protein levels in prostate cancer cells expressing a dominant negative mutant of p66Shc PMID: 21616139
    10. MtF is involved in the pathology of Alzheimer's disease and may play a neuroprotective role against oxidative stress PMID: 21799823
    11. MtF expression is downregulated during ATRA-induced K562 cell differentiation, with concomitant downregulation of TfR1 and upregulation of Fn. PMID: 20369475
    12. The analysis suggests that sequence variations in the coding region of FtMt are not involved in the development of myelodysplastic syndromes and Parkinson's disease. PMID: 20939738
    13. Primary spontaneous pneumothorax in smokers is associated with lung macrophage oxidative stress. The response to this condition involves HIF-1alpha-mediated induction of HO-1, BVR and H-ferritin. PMID: 20526373
    14. Human mitochondrial ferritin expressed in HeLa cells incorporates iron and affects cellular iron metabolism PMID: 11953424
    15. RT-PCR studies showed MtF mRNA in circulating reticulocytes of 2 X-linked sideroblastic anemia patients but not controls. Most of the iron in perinuclear mitochondria of ring sideroblasts is in the form of MtF, a specific marker of sideroblastic anemia. PMID: 12406866
    16. In contrast to previously published literature, this study demonstrates that the putative nucleation site does not play an important role in iron uptake or mineralization in H-chain ferritin. PMID: 15065877
    17. Data reveal striking differences in iron oxidation and hydrolysis chemistry between human mitochondrial ferritin and human H-chain ferritin despite their similar diiron ferroxidase centers. PMID: 15755449
    18. ferritin H not only responds to changes in tissue iron (its classic role), but can actively regulate overall tissue iron balance PMID: 16448386
    19. These results suggest that hemin activates the transcription of the ferritin H gene during K562 erythroid differentiation by Ref-1-mediated activation of these b-zip transcription factors to the Antioxidant-responsive Elements. PMID: 16537925
    20. functional analysis of an H ferritin promoter allele carrying a G to T substitution adjacent to the Bbf binding site, in position -69 PMID: 16797877
    21. Demonstrated iron uptake by ferritins into multiple organs. Uptake is greater when iron delivered by H-ferritin compared to L-ferritin. PMID: 17459943
    22. PIAS3 is a new regulator of ATF1 that regulates the ARE-mediated transcription of the ferritin H gene PMID: 17565989
    23. ionomycin-mediated induction of ferritin H may occur in an NFAT-independent manner but through post-transcriptional stabilization of the ferritin H mRNA. PMID: 18076382
    24. Frataxin has some roles in controlling the balance between different mitochondrial iron pools that are partially in common with those of mitochondrial ferritin. PMID: 18160053
    25. ferritin H transcription is activated by rotenone via an oxidative stress-mediated pathway leading to antioxidant-responsive element activation PMID: 18325346
    26. p53 overexpression strongly downregulates the transcriptional efficiency driven by an H ferritin promoter construct containing only the NF-Y recognition sequence. PMID: 18372207
    27. ferritin pore gating influences to the amount of iron (59Fe) in ferritin in vivo PMID: 18805796
    28. FtMt expression in fibroblasts from Friedreich ataxia patients prevented the formation of reactive oxygen species and partially rescued the impaired activity of mitochondrial Fe-S enzymes. PMID: 18815198
    29. Data present density functional theory optimizations of structures of dizinc(II) complexes with a model of the ferroxidase center of human H ferritin, and the results compared with the crystallographically determined structure of the complex. PMID: 19585161
    30. Increased numbers of mitochondria in neurons in restless legs syndrome (RLS) and increased mitochondrial ferritin might contribute to insufficient cytosolic iron levels in RLS substantia nigra neurons. PMID: 19816198

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  • 亞細胞定位：
    Mitochondrion.
  • 蛋白家族：
    Ferritin family
  • 組織特異性：
    Detected in testis and erythroleukemia. Expression is very low or not detectable in brain, colon, heart, kidney, liver, lung, muscle, placental, spleen and small intestine.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 17345

    OMIM: 608847

    KEGG: hsa:94033

    STRING: 9606.ENSP00000313691

    UniGene: Hs.105324



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