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  4. Recombinant Human Fanconi anemia group B protein (FANCB), partial

Recombinant Human Fanconi anemia group B protein (FANCB), partial

  • 中文名稱：
    人FANCB重組蛋白
  • 貨號：
    CSB-YP818751HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人FANCB重組蛋白
  • 貨號：
    CSB-EP818751HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人FANCB重組蛋白
  • 貨號：
    CSB-EP818751HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人FANCB重組蛋白
  • 貨號：
    CSB-BP818751HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人FANCB重組蛋白
  • 貨號：
    CSB-MP818751HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    FANCB
  • Uniprot No.：
  • 別名：
    FA2; FAAP90; FAAP95; FAB; FACB; Fancb; FANCB_HUMAN; Fanconi anemia associated polypeptide of 95 kDa ; Fanconi anemia group B protein; Fanconi anemia; complementation group B; Fanconi anemia-associated polypeptide of 95 kDa; Protein FACB
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    DNA repair protein required for FANCD2 ubiquitination.
  • 基因功能參考文獻：
    1. We identified a 9154 bp intragenic duplication in FANCB, covering the first coding exon 3 and the flanking regions. The duplicated allele gives rise to an aberrant transcript containing exon 3 duplication, predicted to introduce a stop codon in FANCB protein (p.A319*). PMID: 29193904
    2. Four single nucleotide polymorphisms were identified, three of which were located in untranslated regions of Fanconi anemia group B protein (FANCB) and predicted to be associated with normal function. PMID: 29491055
    3. Loss-of-function FANCB mutations result in a recognizable, multiple malformation phenotype in hemizygous males for which we propose clinical criteria to aid diagnosis. PMID: 21910217
    4. Inactivation of FancB may play a role in the pathogenesis of sporadic HNSCC. PMID: 20332657
    5. Elevated serum FA-2 was associated with bony metastases from breast cancer. PMID: 20465790
    6. the protein defective in individuals with Fanconi anemia belonging to complementation group B is an essential component of the nuclear protein 'core complex' responsible for monoubiquitination of FANCD2 PMID: 15502827
    7. summary of recent advances in the Fanconi anemia-BRCA network with emphasis on the new discovery of FAAP95 as the true FANCB gene [review] PMID: 15611632
    8. Mutations in FANCB are a cause of X linked VACTERL-H syndrome. PMID: 16679491
    9. Mus81 and FANCB have different roles in repair of DNA damage during replication in human cells PMID: 17903171
    10. Our results rule out a major contribution of FANCB to hereditary breast cancer. PMID: 18302019

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  • 相關疾病：
    Fanconi anemia complementation group B (FANCB)
  • 亞細胞定位：
    Nucleus.
  • 數據庫鏈接：

    HGNC: 3583

    OMIM: 300514

    KEGG: hsa:2187

    STRING: 9606.ENSP00000326819

    UniGene: Hs.554740



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