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  4. Recombinant Human FYVE and coiled-coil domain-containing protein 1 (FYCO1), partial

Recombinant Human FYVE and coiled-coil domain-containing protein 1 (FYCO1), partial

  • 中文名稱：
    人FYCO1重組蛋白
  • 貨號(hào)：
    CSB-YP866262HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人FYCO1重組蛋白
  • 貨號(hào)：
    CSB-EP866262HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人FYCO1重組蛋白
  • 貨號(hào)：
    CSB-EP866262HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人FYCO1重組蛋白
  • 貨號(hào)：
    CSB-BP866262HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人FYCO1重組蛋白
  • 貨號(hào)：
    CSB-MP866262HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    CATC2; CTRCT18; DKFZp779K1152; FLJ13335; FYCO1; FYCO1_HUMAN; FYVE and coiled coil domain containing 1; FYVE and coiled coil domain containing protein 1; FYVE and coiled-coil domain-containing protein 1; MGC126517; MGC126519; RUFY3; RUN and FYVE domain containing 3; ZFYVE7; Zinc finger FYVE domain containing protein 7; Zinc finger FYVE domain-containing protein 7
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    May mediate microtubule plus end-directed vesicle transport.
  • 基因功能參考文獻(xiàn)：
    1. FYCO1 regulates accumulation of post-mitotic midbodies by mediating LC3-dependent midbody degradation PMID: 29196475
    2. FYCO1 and MAP1LC3A interact through a novel binding mode that involves Atg8-family proteins PMID: 27246247
    3. Rare missense variants in FYCO1 are overrepresented in sporadic inclusion body myositis patients. PMID: 28009083
    4. FYCO1 requires a functional LC3A/B-preferring LC3-interacting Region (LIR) motif to facilitate efficient maturation of autophagosomes under basal conditions, whereas starvation-induced autophagy was unaffected PMID: 26468287
    5. FYCO1 is involved in lens development and transparency in humans, and mutations in this gene are one of the most common causes of autosomal-recessive congenital cataracts in the Pakistani population. PMID: 21636066
    6. We have characterized the LC3-, Rab7-, and phosphatidylinositol-3-phosphate-binding domains in FYCO1 and mapped part of the CC region essential for MT plus end-directed transport. PMID: 20100911
    7. Maps to a region of chromosome 3p21.3 which is frequently deleted in tumors. PMID: 11896456

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  • 相關(guān)疾病：
    Cataract 18 (CTRCT18)
  • 亞細(xì)胞定位：
    Cytoplasmic vesicle, autophagosome. Endosome. Lysosome. Note=Localizes to the external but not to the internal membrane of autophagosomes, and upon autophagosome/late endosome/lysosome fusion, it stays on the external surface of autolysosomes.
  • 組織特異性：
    Expressed in heart and skeletal muscle.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 14673

    OMIM: 607182

    KEGG: hsa:79443

    STRING: 9606.ENSP00000296137

    UniGene: Hs.200227



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