在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Exosome complex component RRP45 (EXOSC9 PMSCL1)

  • 中文名稱:
  • 貨號:
    CSB-YP007897HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-EP007897HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-EP007897HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-BP007897HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-MP007897HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    EXOS9
  • Uniprot No.:
  • 別名:
    Exosome complex component RRP45; Autoantigen PM/Scl 1; Exosome component 9; P75 polymyositis-scleroderma overlap syndrome-associated autoantigen; Polymyositis/scleroderma autoantigen 1; Polymyositis/scleroderma autoantigen 75 kDa; PM/Scl-75; EXOSC9 PMSCL1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds to ARE-containing RNAs.
  • 基因功能參考文獻:
    1. variants in EXOSC9 result in a neurological syndrome combining cerebellar atrophy and spinal motoneuronopathy, thus expanding the list of human exosomopathies. PMID: 29727687
    2. Although not required for exosome stability, PM/Scl-100 and PM/Scl-75 are involved in mRNA degradation. PMID: 17545563
    3. Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring. PMID: 12419256
    4. The association of the human PM/Scl-75 autoantigen with the exosome is dependent on a newly identified N terminus. PMID: 12788944
    5. The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements, possibly by direct binding of PM/Scl-75 to these RNA regions. PMID: 11782436
    6. PM-Scl-75 is the main autoantigen in patients with the polymyositis/scleroderma overlap syndrome. PMID: 14872500

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm.; [Isoform 1]: Nucleus, nucleolus.; [Isoform 2]: Nucleus, nucleolus.; [Isoform 3]: Nucleus. Note=Excluded from the nucleolus.
  • 蛋白家族:
    RNase PH family
  • 數據庫鏈接:

    HGNC: 9137

    OMIM: 606180

    KEGG: hsa:5393

    STRING: 9606.ENSP00000368984

    UniGene: Hs.91728



主站蜘蛛池模板: av狠狠色超碰丁香婷婷综合久久 | 影音先锋在线资源无码| 天天躁日日躁狠狠躁2018| 久久久久久亚洲精品成人| 国产午精品午夜福利757视频播放| 狠狠色狠狠色综合日日五| 日本丰满熟妇videossex8k| 欧美高清精品一区二区| 国产在不卡免费一区二区三| 真人床震高潮全部视频免费| 毛片免费视频肛交颜射免费视频 | 无码国内精品人妻少妇蜜桃视频 | 精品福利一区二区三区免费视频| 久久综合一色综合久久小蛇| 乌克兰性欧美精品高清| 狠狠躁18三区二区一区ai明星| 日本肥老妇色xxxxx日本老妇| 久久香蕉综合色一综合色88| 成人爽a毛片在线视频淮北| 国产精品久久久久9999高清| 女人被弄到高潮的免费视频| 中文日产乱幕九区无线码| 伊人久久大香线蕉av五月天| 日韩一欧美内射在线观看| 人妻精品久久久久中文字幕| 999久久久无码国产精品| 亚洲精品成av人片天堂无码| 日本sm/羞辱/调教/捆绑视频 | 亚洲国产精品18久久久久久| 亚洲制服丝中文字幕| 人妻无码久久一区二区三区免费 | 内射视频←www夜| 四虎影视在线观看2413| 精品无码一区二区三区爱欲九九 | 久久久一本精品99久久精品66直播| 国产鲁鲁视频在线观看| 日本伊人色综合网| 亚洲中文字幕日产乱码在线| 午夜dj在线观看高清在线视频完整版| 久久婷婷五月综合色99啪| 色8激情欧美成人久久综合电影|