在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Excitatory amino acid transporter 4 (SLC1A6), partial

  • 中文名稱:
    人SLC1A6重組蛋白
  • 貨號:
    CSB-EP021437HU
  • 規格:
    ¥1536
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
  • Uniprot No.:
  • 別名:
    SLC1A6; EAAT4Excitatory amino acid transporter 4; Sodium-dependent glutamate/aspartate transporter; Solute carrier family 1 member 6
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 來源:
    E.coli
  • 分子量:
    40.4kDa
  • 表達區域:
    149-271aa
  • 氨基酸序列
    MVTIIHPGKGSKEGLHREGRIETIPTADAFMDLIRNMFPPNLVEACFKQFKTQYSTRVVTRTMVRTENGSEPGASMPPPFSVENGTSFLENVTRALGTLQEMLSFEETVPVPGSANGINALGL
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal GST-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate.
  • 基因功能參考文獻:
    1. Decreased SLC1A6 expression in neuregulin 1 risk variant may be an adaptive effect to restore glutamate signalling in schizophrenia patients. PMID: 22424243
    2. A twofold difference in functional EAAT4 levels is sufficient to alter signaling to Bergman glia in reporter mice. PMID: 22302796
    3. strate-dependent gating of anion channels associated with excitatory amino acid transporter 4. PMID: 21572047
    4. a conserved aspartate determines pore properties of anion channels associated with excitatory amino acid transporter 4 (EAAT4) PMID: 20519505
    5. At least one susceptibility locus for schizophrenia may be located within or nearby SLC1A6. PMID: 17221839
    6. Independent, rather than cooperative anion conductance gating significantly alters predictions of the influence that EAAT4-mediated anion currents will have on synaptic transmission at low glutamate concentrations. PMID: 17360917
    7. conclusion, maximal glutamate transport modulation by SGK1 is accomplished by direct EAAT4 stimulation and to a lesser extent by inhibition of intrinsic Nedd4-2. PMID: 17442044

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family, SLC1A6 subfamily
  • 組織特異性:
    Brain. Expressed densely and selectively in cell bodies of Purkinje cells.
  • 數據庫鏈接:

    HGNC: 10944

    OMIM: 600637

    KEGG: hsa:6511

    STRING: 9606.ENSP00000221742

    UniGene: Hs.515217



主站蜘蛛池模板: 国产综合在线观看| 国产伦精品一区二区三区妓女| 免费人成视频x8x8| 国产乱对白刺激视频| 国产精品久久自在自线不卡| 国产亚洲精品久久久闺蜜| 亚洲国产果冻传媒av在线观看| 人人妻人人妻人人片av| 草草影院精品一区二区三区| 亚洲精品无码久久久久不卡| 内射极品少妇xxxxxhd | 中文字幕在线播放| 人妻人人澡人人添人人爽| 亚洲综合色婷婷六月丁香宅男大增| 香草乱码一二三四区别| 夜夜添无码一区二区三区| 欧美老熟妇又粗又大| 日韩av一国产av一中文字慕| 中文字幕亚洲综合久久青草| 五月丁香啪啪| 无码尹人久久相蕉无码| av无码人妻波多野结衣| 熟妇人妻av中文字幕老熟妇| 中文字幕日本人妻久久久免费| 国产综合精品| 老司机久久一区二区三区| 国模雨珍浓密毛大尺度150p| 亚洲熟女一区二区三区| 欧美成人综合久久精品| 色五月丁香五月综合五月| 午夜成人鲁丝片午夜精品| 亚洲国产综合精品 在线 一区| 亚洲中文字幕在线精品2021| 亚洲线精品一区二区三区影音先锋| 成品人视频ww入口| 免费无码成人av在线播| 强制高潮18xxxxhd日韩| 午夜性刺激免费看视频| 国产精品欧美福利久久| 欧美精品18videos性欧美| 又大又粗弄得我出好多水|