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  4. Recombinant Human Estrogen sulfotransferase (SULT1E1)

Recombinant Human Estrogen sulfotransferase (SULT1E1)

  • 中文名稱：
    人SULT1E1重組蛋白
  • 貨號：
    CSB-YP022941HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SULT1E1重組蛋白
  • 貨號：
    CSB-EP022941HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SULT1E1重組蛋白
  • 貨號：
    CSB-EP022941HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SULT1E1重組蛋白
  • 貨號：
    CSB-BP022941HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SULT1E1重組蛋白
  • 貨號：
    CSB-MP022941HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SULT1E1
  • Uniprot No.：
  • 別名：
    EST; EST-1; EST1; Estrogen sulfotransferase; estrogen-preferring; estrone sulfotransferase; ST1E1; ST1E1_HUMAN; STE; Sulfotransferase 1E1; Sulfotransferase; Sulfotransferase estrogen preferring; Sulfotransferase family 1E member 1; SULT1E1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-294
  • 氨基酸序列
    MNSELDYYEK FEEVHGILMY KDFVKYWDNV EAFQARPDDL VIATYPKSGT TWVSEIVYMI YKEGDVEKCK EDVIFNRIPF LECRKENLMN GVKQLDEMNS PRIVKTHLPP ELLPASFWEK DCKIIYLCRN AKDVAVSFYY FFLMVAGHPN PGSFPEFVEK FMQGQVPYGS WYKHVKSWWE KGKSPRVLFL FYEDLKEDIR KEVIKLIHFL ERKPSEELVD RIIHHTSFQE MKNNPSTNYT TLPDEIMNQK LSPFMRKGIT GDWKNHFTVA LNEKFDKHYE QQMKESTLKF RTEI
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency. Does not sulfonate cortisol, testosterone and dopamine.
  • 基因功能參考文獻：
    1. Galeterone and abiraterone are novel inhibitors of DHEA sulfonation, as determined in enzymatic incubations containing human tissue cytosol (liver or intestinal) or human recombinant SULT enzyme (SULT2A1, SULT2B1b, or SULT1E1). PMID: 29436390
    2. Single nucleotide polymorphisms in SULT1E1 were significantly associated with time to treatment failure in men on abiraterone acetate therapy. The single nucleotide polymorphisms may serve as predictive markers for treatment with abiraterone acetate. PMID: 27150425
    3. Resveratrol and all its derivatives reduced also SULT1E1 mRNA transcript level. The reduced expression of AhR, CYP1A1, and 1B1 was also found as a result of treatment with these compounds. PMID: 27854074
    4. Data show that both estrogen sulfatase (STS) and estrogen sulfotransferase (EST) were highly expressed in the human umbilical vein PMID: 26458420
    5. Effects of steroid hormone on estrogen sulfotransferase and on steroid sulfatase expression in endometriosis tissue and stromal cells PMID: 26723541
    6. a model that enables prediction of substrates and inhibitors of SULT1E1, is reported. PMID: 26542807
    7. It metabolizes breast cancer drugs like afimoxifene and endoxifen by sulfation. PMID: 26169578
    8. Data suggest that the substrate specificities of SULT1E1 and SULT1A1*1 include metabolites of tamoxifen (endoxifen, 4-hydroxytamoxifen, and N-desmethyltamoxifen); these metabolites are weak inhibitors of sulfation of estradiol by SULT1E1/SULT1A1*1. PMID: 25819444
    9. Authors propose that the formation of this DNA loop and protein-bound complex prevents additional binding of ETS1 and p53 R273H proteins to other proximal binding sites. PMID: 24481480
    10. Data indicate that protein-ligand interaction energy by using docking Quantitative Structure-Activity Relationships(QSAR) models showed accuracy of 67.28%, 78.00% and 75.46%, for the isoforms SULT1A1, SULT1A3 and SULT1E1, respectively. PMID: 24039991
    11. Overexpression of EST promoted adipogenesis. PMID: 24567372
    12. Report diterpenoid extracts from Leonurus sibiricus L. with estrogen sulfotransferase inhibitory activity. PMID: 23736977
    13. Knock-down of SULT1E1 in HUVECs resulted in regulation of genes involved in inflammation and lipid metabolism. PMID: 23384540
    14. Decrease or deletion of EST in the mammary gland may be related to the development of hypertrophic breast, especially gland-associated hypertrophic breast. PMID: 21548389
    15. study showed expression patterns of SULT1E1 and PAPSS in breast and endometrial tissues; the estrogen sulfation enzymes were comparatively higher in the tumorous tissues than adjacent normal tissues; overexpression of SULT1E1 and PAPSS1 retarded MCF-7 cells growth in vivo and in vitro by arresting cell cycles and inducing apoptosis PMID: 22380844
    16. Using two iterative rounds of evolution, we generated SULT1E1 mutants with increased thermostability. PMID: 22197379
    17. results demonstrate that SULT1E1 expression in MCF10A breast epithelial cells cells is transcriptionally regulated by confluence through a suppressive action of the AhR, which is not mediated through a dioxin response element at nt -3476 PMID: 21828262
    18. Identification of the upstream enhancer of the SULT1E1 promoter that plays a crucial role in regulating the activity of SULT1E1 transcription. PMID: 21764778
    19. Recent results of STS and EST in several estrogen-dependent carcinomas, are summarised. PMID: 21073915
    20. estrogen sulfotransferase is expressed in abdominal sc adipose tissue of both obese males and females in association with expression of TNF-alpha and SOCS3, suggesting potential roles in inflammation. PMID: 21543429
    21. Human EST (a dimer of identical protomers) presents a clear example of half-sites reactivity--only one subunit of the dimer produces product during the catalytic cycle. It is the first example of half-sites reactivity in the sulfotransferase family. PMID: 20429582
    22. Murine SULT1E1 inhibition in vitro and in silico was investigated and compared this to data for the human enzyme. PMID: 20025931
    23. linkage to SULT1B1 and to a SULT1D1 pseudogene on chromosome 4 PMID: 11688987
    24. crystal structure of human EST (hEST) in the context of the V269E mutant-PAPS complex, which is the first structure containing the active sulfate donor for any sulfotransferase PMID: 11884392
    25. Levels of steroid sulfatase and STS mRNA and activity may be significantly associated with degree of atherosclerotic changes in female aorta, which may be related to cytokines produced in situ, such as IL-1beta, in human atherosclerotic lesions. PMID: 14507642
    26. estrogen-dependent cell growth of the EST-transfected cell clones was found to be abolished, due to the enhanced sulfoconjugation of estrogen PMID: 14556660
    27. Decreased estrogen sulfotransferase expression is associated with estrogen-dependent endometrial carcinomas PMID: 15355916
    28. Women with the SULT1E1 *959 GA/AA genotype had a moderately decreased breast cancer risk compared with those with the GG genotypes. They had an increased risk of recurrence compared with the TT geonotype PMID: 15894657
    29. Sulfation of resveratrol in human liver: evidence of a major role for the sulfotransferases SULT1E1. PMID: 16418064
    30. EST 1E1 mRNA and protein were found to be expressed in epithelial cells bordering alveola lumen (luminal cells) as well as stroma cells in the prostate PMID: 17187396
    31. Altered cellular proliferation was observed in cells stably expressing SULT1E1. PMID: 17293380
    32. Down-regulation of epithelial estrogen sulfotransferase was associated with high-grade ductal carcinoma in situ in breast cancer PMID: 17661084
    33. a decreased single nucleotide polymorphism of CYP1A1 and an increased single nucleotide polymorphism for SULT1A1 and SULT1E1 genes may be risk factors for endometrial cancer in Caucasians. PMID: 18318428
    34. Data show higher levels for EST mRNA were obtained in polycystic ovarian syndrome endometria without treatment versus normal endometria. PMID: 18467089
    35. Activation of glucocorticoid receptor by dexamethasone induced the activity of estrogen sulfotransferase (SULT1E1), an enzyme important for the metabolic deactivation of estrogens, because sulfonated estrogens fail to activate the estrogen receptor. PMID: 18794126
    36. Data show that SULT1E1 expression in HepG2 cells is inducible by sterol mediated liver-X-receptor (LXR) activation. PMID: 19429440
    37. SULT1E1 mRNA is expressed in human skin, at higher levels in men than women (3-4 times greater arm and hip). No gender difference in face skin. SUL1E1 mRNA levels are not altered by topical 17-beta-estradiol treatment. PMID: 18794456

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  • 亞細胞定位：
    Cytoplasm, cytosol.
  • 蛋白家族：
    Sulfotransferase 1 family
  • 組織特異性：
    Liver, intestine and at lower level in the kidney.
  • 數據庫鏈接：

    HGNC: 11377

    OMIM: 600043

    KEGG: hsa:6783

    STRING: 9606.ENSP00000226444

    UniGene: Hs.479898



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