在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Epidermal growth factor receptor kinase substrate 8 (EPS8), partial

Recombinant Human Epidermal growth factor receptor kinase substrate 8 (EPS8), partial

  • 中文名稱：
    人EPS8重組蛋白
  • 貨號：
    CSB-YP615539HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人EPS8重組蛋白
  • 貨號：
    CSB-EP615539HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人EPS8重組蛋白
  • 貨號：
    CSB-EP615539HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人EPS8重組蛋白
  • 貨號：
    CSB-BP615539HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人EPS8重組蛋白
  • 貨號：
    CSB-MP615539HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    EPS8
  • Uniprot No.：
  • 別名：
    Epidermal growth factor receptor kinase substrate 8; Epidermal growth factor receptor pathway substrate 8; EPS 8; EPS8; EPS8_HUMAN
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes.
  • 基因功能參考文獻：
    1. Data showed that chronic myeloid leukemia (CML) patients expressed a higher level of EPS8 mRNA in bone marrow mononuclear cells. Functional results revealed that EPS8 regulated multiple biological functions such as proliferation, apoptosis, cell cycle, drug sensitivity of CML cells possibly by mediating the regulation of the BCR-ABL/AKT/mTOR signalling pathway. PMID: 29192326
    2. These results indicate that plasma-membrane-associated PTK6 phosphorylates Eps8, which promotes cell proliferation, adhesion, and migration PMID: 28214294
    3. Eps8/Abi1/Sos1 tricomplex acts as a key molecular switch altering the balance between Rac1 and Rho activation; its presence or absence in pancreatic ductal adenocarcinoma cells modulates alphavbeta6-dependent functions, resulting in a pro-migratory (Rac1-dependent) or a pro-TGF-beta1 activation (Rho-dependent) functional phenotype PMID: 28608476
    4. Immunohistochemistry revealed that Eps8 was significantly increased in cervical cancer specimens compared with squamous intraepithelial lesion and normal cervical tissues. Additionally, it was revealed that Eps8 expression not only correlated with cervical cancer progression, but also exhibited a close correlation with the epithelialmesenchymal transition (EMT) markers, Ecadherin and vimentin. PMID: 27573546
    5. Eps8 is required for continuous membrane blebbing. PMID: 26976596
    6. Erk activity promotes actin bundling by Eps8 to enhance cortex tension and drive the bleb-based migration of cancer cells under non-adhesive confinement. PMID: 26163656
    7. Eps8 is a crucial mediator of Src- and FAK-regulated processes. PMID: 25359883
    8. Eps8 is overexpressed in human breast cancers, possibly by regulating ERK signaling, MMP9, p53 and EMT-like transition to affect breast cancer cell growth, migration and invasion. PMID: 25333707
    9. EPS8, as MDR1 and WT1, may be a clinically valuable biomarker for assessing the outcome of ALL patients. PMID: 25843487
    10. These results indicate that employing the native and modified epitopes identified here in Eps8-based immunotherapy for HLA-A2.1 positive cancer patients may result in efficient anticancer immune responses for diverse tumor types. PMID: 25376540
    11. The ITSN2 interacts with Eps8 and stimulates the degradation of Eps8 proteins. PMID: 22449706
    12. EPS8 is an F-actin capping and bundling protein. Mutant mice lacking EPS8 (Eps8-/- mice), which is present in the hair bundle, the sensory antenna of the auditory sensory cells that operate the mechano-electrical transduction PMID: 24741995
    13. Eps8 functions as a key coordinator in the interplay between FGFR signalling and trafficking. PMID: 23203811
    14. results suggest that Eps8 may serve as a prognostic factor of responsiveness to chemotherapy in AML patients PMID: 24409660
    15. Novel binding partners and differentially regulated phosphorylation sites clarify Eps8 as a multi-functional adaptor. PMID: 23626693
    16. Eps8 is frequently expressed in OSCC. The aberrant expression of Eps8 closely correlated with poor survival in patients with OSCC. PMID: 22897151
    17. We found that Eps8 mediates cell proliferation and survival of glioma cells, at least in part, by affecting phosphorylated ERK and Akt/beta-catenin activities. PMID: 23229386
    18. Identify Fbxw5-driven fluctuation of Eps8 levels as an important mechanism that contributes to cell-shape changes during entry into-and exit from-mitosis. PMID: 23314863
    19. The loss of EPS8 expression in colorectal adenomas and carcinomas suggests that down regulation of this gene contributes to the development of a subset of colorectal cancers. PMID: 22876043
    20. silencing of the protein by siRNA abrogated the migratory and invasive capacity of three different glioblastoma cell lines both in 2-dimensional and 3-dimensional in vitro assays. PMID: 22683923
    21. Eps8 is a key regulator of the LPS-stimulated TLR4-MyD88 interaction and contributes to macrophage phagocytosis PMID: 22493489
    22. Studied generation of filopodia with regards to the dynamic interaction established by Eps8, IRSp53 and VASP with actin filaments. PMID: 21814501
    23. critical role for JNK2 and EPS8 in receptor tyrosine kinase signaling and trafficking to convey distinctly different effects on cell migration. PMID: 21357683
    24. Study implicates that the integrity of SOS1/EPS8/ABI1 tri-complex is a determinant of ovarian cancer metastasis. PMID: 21118970
    25. IRSp53, through its interaction with Eps8, not only affects cell migration but also dictates cellular growth in cancer cells. PMID: 20418908
    26. Overexpression of EPS8 induced expression of the chemokine ligands CXCL5 and CXCL12 in a FOXM1-dependent manner, which was blocked by LY294002 or a dominant-negative form of AKT PMID: 20351091
    27. Eps8 is recruited to lysosomes and subjected to chaperone-mediated autophagy in cancer cells PMID: 20184880
    28. Involved in the growth factor-controlled regulation of cell proliferation and differentiation in the seminiferous epithelium. PMID: 15273867
    29. These results support a model whereby the synergic bundling activity of the IRSp53-Eps8 complex, regulated by Cdc42, contributes to the generation of actin bundles, thus promoting filopodial protrusions. PMID: 17115031
    30. Eps8 is essential for actin dynamics and cell interactions, independent of Eps8-like gene products. PMID: 17537571
    31. These findings implicate the involvement of Eps8 in chemoresistance and show its importance in prognosis of cervical cancer patients. PMID: 18566210
    32. overexpression of EPS8 in HN4 cells was sufficient to induce growth of non-tumorigenic cells in orthotopic transplantation assays. EPS8 expression in samples of squamous cell carcinoma showed variable expression levels and paralleled expression of MMP-9 PMID: 19008210
    33. A role of Eps8 in amplifying growth factor receptor signaling in human pituitary tumors to promote proliferation and cell survival. PMID: 19116338
    34. Results show that alphavbeta6- and alpha5beta1-integrin-dependent activation of Rac1 was mediated through Eps8. PMID: 19448673
    35. the crystal structures of human LanCL1, both free of and complexed with glutathione, revealing glutathione binding to a zinc ion at the putative active site formed by conserved GxxG motifs PMID: 19528316

    顯示更多

    收起更多

  • 相關疾病：
    Deafness, autosomal recessive, 102 (DFNB102)
  • 亞細胞定位：
    Cytoplasm, cell cortex. Cell projection, ruffle membrane. Cell projection, growth cone. Cell projection, stereocilium. Cell junction, synapse, synaptosome.
  • 蛋白家族：
    EPS8 family
  • 組織特異性：
    Expressed in all tissues analyzed, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in all epithelial and fibroblastic lines examined and in some, but not all, hematopoietic cells.
  • 數據庫鏈接：

    HGNC: 3420

    OMIM: 600206

    KEGG: hsa:2059

    STRING: 9606.ENSP00000281172

    UniGene: Hs.591160



主站蜘蛛池模板： 国产精品老热丝在线观看| 国产精品日本亚洲777| 精品无码久久久久国产| 亚洲男人的天堂在线播放| 香蕉免费一区二区三区在 | 丰满少妇被猛烈进入试看| 人人妻人人澡人人爽| 欧美日韩一区二区三区自拍| 无码国产片观看| 福利姬国产精品一区在线| 黑森林福利视频导航| 猫咪av成人永久网站在线观看| 亚洲精品国产一区二区精华| 九九久久精品国产| 性色av免费观看| 碰超免费人妻中文字幕| 综合 欧美 小说 另类 图| 亚洲无av在线中文字幕| 日日摸天天摸爽爽狠狠97| 国内精品国语自产拍在线观看| а天堂中文最新版在线| 精品人妻一区二区三区浪潮在线| 色综合av男人的天堂伊人| 亚洲国产一成人久久精品| 黑人玩弄人妻中文在线| 亚洲中文字幕无码爆乳app| 国产精品高清一区二区不卡片| 国产精品夜夜春夜夜爽久久小说| 精品无码国产一区二区三区51安| 亚洲无线观看国产精品| 国产亚洲日韩妖曝欧美| 国产精品一区二区熟女不卡| 日本最新免费二区| 久久久久 亚洲 无码 av 专区 | 欧美三级欧美成人高清| 欧美人与动性xxxxx杂性| 欧美人与禽猛交狂配| 精品无码久久久久国产电影| 热99re久久精品这里都是精品| 午夜福利视频合集1000| 精品亚洲成a人片在线观看|