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Recombinant Human Endothelial protein C receptor (PROCR), partial

  • 中文名稱:
    人PROCR重組蛋白
  • 貨號(hào):
    CSB-EP892160HU
  • 規(guī)格:
    ¥1272
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
  • Uniprot No.:
  • 別名:
    Activated protein C receptor; APC receptor; APCR; bA42O4.2; CCCA ; CCD41; CD201; CD201 antigen ; cell cycle; centrosome-associated protein; Cell cycle; centrosome-associated protein; centrocyclin; Endothelial cell protein C receptor; Endothelial protein C receptor; EPCR; EPCR_HUMAN; MGC23024; PROCR; Protein C receptor; endothelial
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度:
    Partial
  • 來(lái)源:
    E.coli
  • 分子量:
    26.0kDa
  • 表達(dá)區(qū)域:
    18-210aa
  • 氨基酸序列
    SQDASDGLQRLHMLQISYFRDPYHVWYQGNASLGGHLTHVLEGPDTNTTIIQLQPLQEPESWARTQSGLQSYLLQFHGLVRLVHQERTLAFPLTIRCFLGCELPPEGSRAHVFFEVAVNGSSFVSFRPERALWQADTQVTSGVVTFTLQQLNAYNRTRYELREFLEDTCVQYVQKHISAENTKGSQTSRSYTS
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 6xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.
  • 基因功能參考文獻(xiàn):
    1. PROCR H1 and H3 haplotypes were determined by genotyping 7014G/C and 1651C/G tag-polymorphisms, respectively. The PROCR H1 haplotype was less frequently found in antiphospholipid syndrome patients with arterial thrombosis, suggesting a protective effect of PROCR H1 against arterial thrombosis in these patients. PMID: 30048851
    2. this is the first comprehensive study of PROCR signaling in breast cancer cells, and its findings also shed light on the molecular mechanisms of PROCR in stem cells in normal tissue. PMID: 29217770
    3. The activation of PAR-1 on the cell surface of SGC7901 and AGS cells was significantly reduced after the knockdown of EPCR. By contrast, blockade of PAR-1 reduced the proliferation and migration of gastric cells in vitro PMID: 29484413
    4. analysis of DC8 and DC13 PfEMP1 variants reveals that Plasmodium falciparum-infected erythrocytes-endothelial protein C receptor interaction may be prevented by plasma components under physiological conditions PMID: 29339517
    5. Low EPCR expression is associated with meningococcal purpura fulminans. PMID: 29630665
    6. Our findings suggested that breast cancer patients with expression of PROCR is more prone to suffer from distant metastasis and bad clinical outcomes. PMID: 28756987
    7. Plasma levels of Ang2 were associated with markers of malaria severity and levels of var transcripts encoding P. falciparum Erythrocyte Membrane Protein 1 (PfEMP1) containing Cysteine Rich Inter Domain Region alpha1 (CIDRalpha1) domains predicted to bind Endothelial Protein C receptor (EPCR). PMID: 27784899
    8. The EPCR rs867186-GG genotype is associated with increased soluble protein, and it could mediate protection against severe malaria. PMID: 27255786
    9. The data indicate that EPCR can regulate p63, is associated with highly proliferative keratinocytes, and is a potential human epidermal stem cell marker. PMID: 28480559
    10. Analysis of a cohort of breast cancer patients revealed an association of high EPCR levels with adverse clinical outcome. Interestingly, EPCR knockdown did not affect cell growth kinetics in 2D but reduced cell growth in 3D cultures. EPCR silencing reduced primary tumor growth and secondary outgrowths at metastatic sites. EPCR via SPOCK1 confers a cell growth advantage in 3D promoting breast tumorigenesis and metastasis. PMID: 28103946
    11. analysis of renal endothelial PROCR expression and shedding during diabetic nephropathy PMID: 26990852
    12. EPCR occupancy recruits G-protein coupled receptor kinase 5, thereby inducing beta-arrestin-2 biased PAR1 signaling by both APC and thrombin. In PMID: 27561318
    13. EPCR polymorphisms may be associated with increased risk of sepsis, but this has no effect on the release of soluble EPCR in patients with sepsis. PMID: 28415941
    14. Elevated endothelium-related mediators (vWF, E-selectin and EPCR) appear to participate in the development of pancreatic necrosis and may be a potential indicator of overall prognosis. PMID: 28007459
    15. The results showed that AS-IV could significantly inhibit PMA-induced EPCR shedding. PMID: 28367652
    16. CORM-2 protects human umbilical vein endothelial cells from lipopolysaccharide-induced injury, by way of suppressing NF-kappaB activity, which downregulates TM and EPCR mRNAs. It also decreases MMP-2 expression and prevents the shedding of TM and EPCR from the surface of endothelial cells, so as to preserve their protective effect. PMID: 28538400
    17. This study shows that ICAM-1 is a coreceptor for a subset of EPCR-binding Plasmodium falciparum parasites and provides the first evidence of how EPCR and ICAM-1 interact to mediate parasite binding to both resting and TNF-alpha-activated primary brain and lung endothelial cells. PMID: 27406562
    18. This study demonstrates that impaired EPCR function can be detected by thrombin generation and clot lysis assays on cells expressing thrombomodulin and EPCR. Deficiency in EPCR has procoagulant effects that lead to a delay in clot lysis. PMID: 28219843
    19. Observations that binding of P. falciparum erythrocyte membrane protein 1 to EPCR results in an acquired functional protein C system deficiency support the new paradigm that EPCR plays a central role in the pathogenesis of severe malaria. [review] PMID: 27207424
    20. data suggest that either the lack of the protective EPCR 4678C allele or the presence of EPCR 4600G allele may be associated with earlier development of thrombosis. PMID: 25760048
    21. These data suggest that 6936A/G polymorphism is a risk factor for deep venous thrombosis and is associated with elevated plasma levels of soluble EPCR, while 4678G/C polymorphism plays a role in protection against deep venous thrombosis. PMID: 26340463
    22. Upon ICU admission, sEPCR levels in initially non-septic critically-ill patients appear elevated in the subjects who will subsequently become septic PMID: 25220546
    23. These data reveal a previously unknown functional heterogeneity in the interaction between Plasmodium falciparum PfEMP1 CIDRalpha1domain binding to EPCR and have major implications for understanding the distinct clinical pathologies of cerebral malaria. PMID: 26118955
    24. Overall, these findings reveal a much greater complexity of how Plasmodium falciparum PfEMP1 CIDRalpha1 domain-expressing parasites may modulate malaria pathogenesis through EPCR adhesion. PMID: 26119044
    25. In this Tanzanian population, neither PROCR haplotype nor level of soluble EPCR was associated with severe malaria. PMID: 26620701
    26. Serum soluble EPCR is elevated in Alzheimer's disease. The degree of cognitive impairment is significantly correlated with serum sEPCR levels in Alzheimer's disease and mild cognitive impairment patients and healthy controls. PMID: 25588409
    27. Report activation of protein C and down-regulation of EPCR in trophobolasts stimulated with TNF-alpha. PMID: 25667200
    28. This effect of EPCR may be dependent on PAR1. PMID: 25895599
    29. results did not conclusively identify a direct role of sEPCR in HSP, but our findings warrant further investigations, especially in severe HSP cases characterized by gastrointestinal bleeding or renal involvement PMID: 24308805
    30. The degree of arteriovenous fistula stenosis was not correlated with serum EPCR PMID: 24627030
    31. results demonstrate that EPCR is overexpressed and mediates the aggressive behavior of rheumatoid synovial fibroblasts, and is likely driven by group V secretory phospholipase A2 PMID: 24495480
    32. Individuals exposed to high levels of Plasmodium falciparum PfEMP1 acquire antibodies to EPCR-binding CIDR domains early in life. PMID: 26015475
    33. genetic variation in the PROCR gene in our study population does not influence susceptibility to major severe malaria phenotypes PMID: 25541704
    34. Low PROCR mRNA expression levels associated with a poor prognosis in patients with disseminated intravascular coagulation (DIC) represents an exhaustion of the natural anticoagulant system, and reflects the final decompensate stage of DIC. PMID: 25246042
    35. Increased coagulation activity and genetic polymorphisms in the F5, F10 and EPCR genes are associated with breast cancer. PMID: 25407022
    36. It was concluded that measuring EPCR levels at admission could provide an early biological marker of the outcome of cerebral malaria. PMID: 25425698
    37. EPCR expression in breast cancer cells, despite having initial growth advantage, may have a role in limiting cancer progression at an advanced stage PMID: 24024878
    38. Blocking antibodies to EPCR attenuate in vivo tumor growth and proliferation specifically of EPCR(+) cells on defined integrin matrices in vitro. PMID: 24862151
    39. Elevated levels of soluble endothelial protein C receptor, a sensitive marker of endothelial damage, indicated a low level of inflammation and coagulation activation in Maraviroc treated patients not picked up by other widely used markers. PMID: 22715361
    40. Piperlonguminine might have potential as an anti-sEPCR shedding reagent against PMA-mediated EPCR shedding. PMID: 24127121
    41. The association of PROCR rs867186 with severe malaria is examined in Thai population and showed significant association with protection from severe malaria. PMID: 24635948
    42. The study suggests a putative role of EPCR SNPs in the development of thrombosis in multiple myeloma patients. PMID: 23993723
    43. The EPCR AA genotype was significantly more frequent in the healthy volunteers free of venous thrombosis. PMID: 24158116
    44. 3 polymorphisms in the EPCR gene were genotyped in 389 critically ill Greek patients to assess genetic risk for developing severe sepsis or septic shock. H2 carriers had an excess of ss/ss vs. genotypes H1 and H3. PMID: 23881209
    45. PROCR H1 protects against venous thromboembolism. There is an increased risk of VTE associated with the H3 haplotype. PMID: 24436369
    46. sEPCR acts on the innate immune response by decreasing effector cells such as natural killer and T helper cells (TH2, TH17 and TH21). PMID: 23877403
    47. Increased EPCR-levels correlate with accelerated mortality in patients with melioidosis. PMID: 23875041
    48. EPCR is expressed not only by a wide range of human malignant hematological cells but also the detection of plasma sEPCR levels provides a powerful insight into thrombotic risk assessment in cancer patients, especially when it surpasses 200 ng/mL. PMID: 23342274
    49. conclude that urinary sEPCR could be a novel non-invasive biomarker of antibody mediated rejection in renal transplantation PMID: 23717683
    50. Our data suggest that mutations that impair PC-EPCR interactions may be associated with an increased risk of venous thromboembolism. PMID: 24051141

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  • 亞細(xì)胞定位:
    Membrane; Single-pass type I membrane protein.
  • 組織特異性:
    Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 9452

    OMIM: 600646

    KEGG: hsa:10544

    STRING: 9606.ENSP00000216968

    UniGene: Hs.647450



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