在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Elongin-B (ELOB)

In Stock
  • 中文名稱:
    人ELOB重組蛋白
  • 貨號:
    CSB-EP620878HU
  • 規格:
    ¥1344
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
  • Uniprot No.:
  • 別名:
    EloB; ELOB_HUMAN; Elongin 18 kDa subunit; Elongin B; Elongin-B; RNA polymerase II transcription factor SIII p18 subunit; RNA polymerase II transcription factor SIII subunit B; SIII; SIII p18; TCEB 2; Tceb2; Transcription elongation factor B (SIII) polypeptide 2; Transcription elongation factor B polypeptide 2
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length
  • 來源:
    E.coli
  • 分子量:
    40.1kDa
  • 表達區域:
    1-118aa
  • 氨基酸序列
    MDVFLMIRRHKTTIFTDAKESSTVFELKRIVEGILKRPPDEQRLYKDDQLLDDGKTLGECGFTSQTARPQAPATVGLAFRADDTFEALCIEPFSSPPELPDVMKPQDSGSSANEQAVQ
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal GST-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells.; Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. This includes the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes. A number of ECS complexes (containing either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation.
  • 基因功能參考文獻:
    1. Study shows that TCEB2 is involved in the development of acquired resistance to bevacizumab in ovarian cancer cells via the mechanisms of suppression of VEGF-A expression by promoting HIF-1alpha degradation and induction of interleukin-8 (IL-8) expression. PMID: 26531153
    2. Elongin B also enhances gene expression from the double-stranded DNA genome of human cytomegalovirus. PMID: 21447700
    3. nuclear level of active P-TEFb is controlled by dynamic and reversible remodelling of 7SK snRNP PMID: 17611602
  • 亞細胞定位:
    Nucleus.
  • 數據庫鏈接:

    HGNC: 11619

    OMIM: 600787

    KEGG: hsa:6923

    STRING: 9606.ENSP00000262306

    UniGene: Hs.172772



主站蜘蛛池模板: 男女真人国产牲交a做片野外 | 又粗又硬又黄又爽的视频永久 | 亚洲精品一区国产精品| 成熟女人毛片www免费版在线| 日本熟妇人妻xxxxx| 国产喷水1区2区3区咪咪爱av| 成人美女黄网站色大色费全看 | 男女久久久国产一区二区三区| 日日摸日日碰夜夜爽亚洲 | 亚洲啪av永久无码精品放毛片| 欧美丰满少妇xxxx性| 综合激情亚洲丁香社区| 日本一卡二卡3卡四卡网站精品| 精品欧美一区二区在线观看| 国产成人精品综合久久久久| 国产粉嫩小泬在线观看泬| 人妻熟女久久久久久久| 无卡无码无免费毛片| 女人爽到高潮免费视频大全| 国产一区二区无码蜜芽精品| 日本一丰满一bbw| 综合久久给合久久狠狠狠97色| 日韩一区二区在线观看视频| 欧美人与动人物姣配xxxx| 国产高清在线精品一区二区三区 | 欧美人与禽zozzo性伦交| 2020无码天天喷水天天爽| 国产成人亚洲精品无码h在线| 国产精品久久久国产盗摄| 国产成人8x人网站视频| 日韩不卡1卡2卡三卡网站| 免费无码又爽又刺激网站| 亚洲精品一区二区三区新线路| 中国少妇初尝黑人巨高清| 色诱久久久久综合网ywww| 97精品久久久久中文字幕| 色九月亚洲综合网| 无码少妇一区二区浪潮av| 久久久久成人精品免费播放动漫| 少妇高潮无套内谢| 亚洲精品久久一区二区无卡|