在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 (ENPP7), partial

Recombinant Human Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 (ENPP7), partial

  • 中文名稱：
    人ENPP7重組蛋白
  • 貨號(hào)：
    CSB-YP751012HU1
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人ENPP7重組蛋白
  • 貨號(hào)：
    CSB-EP751012HU1
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人ENPP7重組蛋白
  • 貨號(hào)：
    CSB-EP751012HU1-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人ENPP7重組蛋白
  • 貨號(hào)：
    CSB-BP751012HU1
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人ENPP7重組蛋白
  • 貨號(hào)：
    CSB-MP751012HU1
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ENPP7
  • Uniprot No.：
  • 別名：
    ENPP7; UNQ3077/PRO9912; Ectonucleotide pyrophosphatase/phosphodiesterase family member 7; E-NPP 7; NPP-7; Alkaline sphingomyelin phosphodiesterase; Intestinal alkaline sphingomyelinase; Alk-SMase
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Choline-specific phosphodiesterase that hydrolyzes sphingomyelin releasing the ceramide and phosphocholine and therefore is involved in sphingomyelin digestion, ceramide formation, and fatty acid (FA) absorption in the gastrointestinal tract. Has also phospholipase C activity and can also cleave phosphocholine from palmitoyl lyso-phosphatidylcholine and platelet-activating factor (PAF) leading to its inactivation. Does not have nucleotide pyrophosphatase activity. May promote cholesterol absorption by affecting the levels of sphingomyelin derived from either diet or endogenous sources, in the intestinal lumen.
  • 基因功能參考文獻(xiàn)：
    1. human alkaline sphingomyelinase crystal structure provides insights into substrate recognition PMID: 28292932
    2. NPP7 activity and the ratio of 1.4/1.2 kb products in bile are significantly decreased in malignancy, particularly in cholangiocarcinoma. PMID: 25100243
    3. The F275A mutation of NPP7 showed impaired catalytic function whereas L107F mutation showed enhanced catalytic activity. PMID: 22177013
    4. predict the three-dimensional structure of NPP7 by homology modeling using a recently crystallized NPP from bacteria. Using the model, we studied the substrate specificity of the enzyme by docking. PMID: 20839774
    5. identified the amino acid and cDNA sequences of human intestinal alk-SMase, and found that it is a novel ecto-enzyme related to the ecto-nucleotide phosphodiesterase family with specific features essential for its SMase activity PMID: 12885774
    6. intestinal alkaline sphingomyelinase may have a one-exon deletion in colon cancer cells PMID: 15016655
    7. alk-SMase activity is severely affected by defective N-glycosylation at 5 sites and by structural alterations of the putative metal-binding sites and the predicted active core. PMID: 15458386
    8. Results describe the cloning of rat alkaline sphingomyelinase from rat intestine, comparison to the human sequence, adjustment of the putative protein in GenBank, and confirmation of the specific expression of the gene in the small intestine. PMID: 15708357
    9. Alkaline sphingomyelinase hydrolyses and inactivates PAF by a phospholipase C activity, a novel function by which it may counteract the development of intestinal inflammation and colon cancer. PMID: 16255717

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Nucleotide pyrophosphatase/phosphodiesterase family
  • 組織特異性：
    Detected in the colon (at protein level). Expressed in the duodenum, jejunum and liver and at low levels in the ileum. Expression was very low in the esophagus, stomach and colon.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 23764

    OMIM: 616997

    KEGG: hsa:339221

    STRING: 9606.ENSP00000332656

    UniGene: Hs.114084



主站蜘蛛池模板： 99国产精品99久久久久久| 少妇无码av无码去区钱| 午夜成人无码福利免费视频| 一女被多男玩喷潮视频| 日韩欧美中文字幕在线三区| 亚洲国产成人最新精品 | 精品亚洲aⅴ无码一区二区三区| 精品久久久无码人妻字幂| 欧美性猛交xxxx富婆| 亚洲欧洲免费三级网站| 国产av天堂亚洲国产av天堂| 熟女人妻大叫粗大受不了| 亚洲精品国产第一区第二| 欧美乱大交av片久久123| 97精品国产久热在线观看| 男人女人做爽爽18禁网站| 日韩av无码中文无码不卡电影| √最新版天堂资源在线| 亚洲精品久久国产精品浴池| 欧美巨大黑人精品videos| 亚洲精品一区三区三区在线观看| 亚洲熟女综合一区二区三区| 久久精品私人影院免费看| 毛片无遮挡高清免费| 亚洲精品无码久久久久久| 欧美va免费高清在线观看| 亚洲成a人片在线观看的电影| 国产乱妇无码大片在线观看| 久久精品人妻一区二区蜜桃| s级爆乳玩具酱国产vip皮裤| 又黄又爽又色的免费网站| 久久精品国产一区二区电影| 少妇粉嫩小泬喷水视频| 成人无码免费视频在线播| 2020精品国产自在现线官网| 日产精品一区二区| 在线亚洲精品国产一区麻豆| 亚洲国产成人综合在线不卡| 精品熟女日韩中文十区| 国产精品久久久久久成人影院 | 国产免费久久精品99久久|