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  4. Recombinant Human Early growth response protein 3 (EGR3 PILOT)

Recombinant Human Early growth response protein 3 (EGR3 PILOT)

  • 中文名稱：
  • 貨號：
    CSB-YP007486HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
  • 貨號：
    CSB-EP007486HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
  • 貨號：
    CSB-EP007486HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
  • 貨號：
    CSB-BP007486HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
  • 貨號：
    CSB-MP007486HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    EGR3
  • Uniprot No.：
  • 別名：
    Early growth response protein 3; EGR-3; Zinc finger protein pilot; EGR3 PILOT
  • 種屬：
    Homo sapiens (Human)
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Probable transcription factor involved in muscle spindle development.
  • 基因功能參考文獻：
    1. KSRP decreased EGR3 mRNA stability in an ARE-independent manner. PMID: 28847731
    2. miR-718 acts as a tumor suppressive microRNA in hepatocellular carcinoma via regulating the expression of EGR3, which may provide a new diagnostic marker and treatment target for HCC PMID: 28070994
    3. EGR3 contributes to cell growth inhibition via upregulation of FasL in Hepatocellular carcinoma. PMID: 28098878
    4. These findings support previously reported associations between EGR3 and schizophrenia. PMID: 26474411
    5. EGR3 promotes excessive production of IL6 and IL8 observed during the progression of prostate cancer. PMID: 25633035
    6. Data shows association of Egr3 genetic polymorphisms and coronary artery disease in the Uygur and Han of China PMID: 24886494
    7. Genetic variation in EGR3 may affect prefrontal function through neurodevelopment PMID: 23962955
    8. These results provide the first evidence that Egr-3, is up-regulated in scleroderma and is necessary and sufficient for profibrotic responses. PMID: 23906810
    9. Decreased EGR3 expression might play a critical role in the differentiation, proliferation, metastasis and progression of gastric cancer cells. PMID: 23460371
    10. These data suggest that type I IFN stimulation induces a rapid recruitment of a repressive Egr3/Nab1 complex that silences transcription from the ifngr1 promoter. PMID: 23935197
    11. Our results suggest that Egr-3 is a transcription factor associated with TGF-beta1 expression and in vivo regulatory activity PMID: 23904169
    12. Egr3 mRNA expression reveals that Egr3 mRNA expression is increased in tumor cells of non-relapsed samples compared to normal prostate cells, but is significantly lower in relapsed samples compared to non-relapse. PMID: 23342084
    13. EGR3, a gene that translates environmental stimuli into long-term changes in the brain, may be associated with risk for child bipolar disorder 1. PMID: 22370066
    14. Study supports the association of EGR3 with schizophrenia in Han Chinese sample. PMID: 22276163
    15. EGR3 gene may play an important role in schizophrenia susceptibility PMID: 22425949
    16. EGR3 bound to the TREM-1 promoter. PMID: 21421043
    17. This study demoistrated that ERG3 are not genetic risk factors for schizophrenia in japanese. PMID: 20537399
    18. SNP rs35201266 in intron 1 of the EGR3 gene showed a significant association with schizophrenia PMID: 20687139
    19. Egr-3 is a critical determinant of VEGF signaling in activated endothelial cells PMID: 19965691
    20. Vascularendothelial growth factor induces expression of NR4A nuclear receptors and Egr3 via KDR and KDR-mediated signaling mechanisms. PMID: 14525795
    21. data suggest that Egr3 is a target for the estrogen receptor alpha PMID: 15171706
    22. These findings support the previous genetic association of altered calcineurin signaling with schizophrenia pathogenesis and identify EGR3 as a compelling susceptibility gene. PMID: 17360599
    23. findings indicate that Egr3 has an essential downstream role in VEGF-mediated endothelial functions leading to angiogenesis and may have particular relevance for adult angiogenic processes involved in vascular repair and neovascular disease PMID: 18059339
    24. Enforced expression of Egr3 transgene, from the CD2 antigen promoter, facilitates development of RAG2-deficient double-negative (DN) stage 3 thymocytes to the DN4 stage and subsequently to the double-positive stage of development. PMID: 19124717

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    EGR C2H2-type zinc-finger protein family
  • 數據庫鏈接：

    HGNC: 3240

    OMIM: 602419

    KEGG: hsa:1960

    STRING: 9606.ENSP00000318057

    UniGene: Hs.534313



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