在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human E3 ubiquitin-protein ligase TRIM37 (TRIM37), partial

Recombinant Human E3 ubiquitin-protein ligase TRIM37 (TRIM37), partial

  • 中文名稱：
    人TRIM37重組蛋白
  • 貨號：
    CSB-YP024474HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人TRIM37重組蛋白
  • 貨號：
    CSB-EP024474HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人TRIM37重組蛋白
  • 貨號：
    CSB-EP024474HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人TRIM37重組蛋白
  • 貨號：
    CSB-BP024474HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人TRIM37重組蛋白
  • 貨號：
    CSB-MP024474HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    E3 ubiquitin protein ligase TRIM37; E3 ubiquitin-protein ligase TRIM37; KIAA0898; MUL; MUL protein; Mulibrey nanism gene; Mulibrey nanism protein; POB 1; POB1; RING B box coiled coil protein; TEF 3; TEF3; TRI37_HUMAN; TRIM 37; Trim37; Tripartite motif containing 37 ; Tripartite motif containing 37 protein; Tripartite motif containing protein 37; Tripartite motif-containing protein 37
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    E3 ubiquitin-protein ligase required to prevent centriole reduplication. Probably acts by ubiquitinating positive regulators of centriole reduplication. Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes. Has anti-HIV activity.
  • 基因功能參考文獻：
    1. TRIM37 functions as an oncogene in the development and progression of glioma. PMID: 29324313
    2. TRIM37 mutation is associated with mulibrey nanism. PMID: 28815877
    3. TRIM37-mediated ubiquitylation stabilizes PEX5 and promotes peroxisomal matrix protein import, suggesting that mulibrey nanism is a new peroxisomal biogenesis disorder. PMID: 28724525
    4. TRIM37 was overexpressed in human CRC tissues. High TRIM37 expression resulted in increased CRC proliferation, migration and invasion. Mechanistically, it was confirmed that TRIM37 enhanced invasion and metastasis of CRC via the epithelialmesenchymal transition pathway. PMID: 28098873
    5. knockdown of TRIM37 markedly downregulated the expression of beta-catenin, cyclin D1, and c-Myc in CRC cells. These results suggest that knockdown of TRIM37 inhibits proliferation and tumorigenesis by the inactivation of Wnt/beta-catenin signaling in CRC cells. PMID: 28081740
    6. The oncogenic roles of TRIM37 in pancreatic cancer. PMID: 26395261
    7. These finding may provide insight into the understanding of TRIM37 as a novel critical factor of HCC and a candidate target for HCC treatment. PMID: 26208456
    8. results reveal TRIM37 as an oncogenic H2A ubiquitin ligase that is overexpressed in a subset of breast cancers and promotes transformation by facilitating silencing of tumour suppressors and other genes. PMID: 25470042
    9. Our report underlines the necessity of early clinical diagnosis of Mulibrey nanism. Careful cardiologic examination is required to detect constrictive pericarditis, which is a major factor of mortality in these patients PMID: 23385855
    10. In this study, authors demonstrate that human Trim 37 possesses anti-HIV-1 activity. PMID: 24317724
    11. The TRIM37 gene encodes a peroxisomal RING-B-box-coiled-coil protein: classification of mulibrey nanism as a new peroxisomal disorder PMID: 11938494
    12. novel splice variants observed in lymphoblastoid cells and muscle tissue of normal subjects and mulibrey nanism patients PMID: 12754710
    13. The TRIM37 acts as a TRIM domain-dependent E3 ubiquitin ligase and imply defective ubiquitin-dependent degradation of an as-yet-unidentified target protein in the pathogenesis of mulibrey nanism. PMID: 15885686
    14. Functional link of TRIM37 to the ubiquitin-proteosome pathway may provide novel clues to the development of metabolic syndrome. PMID: 16306379
    15. TRIM37 expression is regulated by several mechanisms: through nonsense surveillance of non-functional transcripts, as well as through 3'UTR regulatory sequences and/or naturally occurring antisense RNAs especially in testis. PMID: 16310976
    16. Novel mutations in the tumor necrosis factor receptor associated factor (TRAF) domain alter the subcellular localization of TRIM37, and are associated with Wilm's tumor in a patient with mulibrey nanism. PMID: 17100991
    17. Mutation screening of the TRIM37 gene revealed that the proband had a homozygous two base pair deletion, c.1894_1895delGA, resulting in a frame-shift and a premature termination codon. PMID: 17551331
    18. inherited biallelic inactivation of TRIM37 (Mulibrey nanism) predisposes to both mesenchymal and epithelial ovarian tumors and dysregulation of TRIM37 may also be involved in the pathogenesis of sporadic fibrothecomas. PMID: 19329943

    顯示更多

    收起更多

  • 相關疾病：
    Mulibrey nanism (MUL)
  • 亞細胞定位：
    Cytoplasm, perinuclear region. Peroxisome.
  • 蛋白家族：
    TRIM/RBCC family
  • 組織特異性：
    Ubiquitous. Highly expressed in testis, while it is weakly expressed in other tissues.
  • 數據庫鏈接：

    HGNC: 7523

    OMIM: 253250

    KEGG: hsa:4591

    STRING: 9606.ENSP00000262294

    UniGene: Hs.579079



主站蜘蛛池模板： 国产成人一区二区精品视频| 爱做久久久久久| 人妻少妇heyzo无码专区| 久久国产精品萌白酱免费| 最新亚洲一卡二卡三卡四卡| 国产精品成人免费视频网站京东| 亚洲综合av永久无码精品一区二区| 欧美日韩无套内射另类| 国产成+人+综合+亚洲欧美| 国产精品久久久久久久久久| 东北妇女精品bbwbbw| 亚洲香蕉aⅴ视频在线播放 | 久久996re热这里有精品 | 么公的好大好硬好深好爽视频| 亚洲日韩高清在线亚洲专区| 中国少妇videos呻吟| 国产精品福利自产拍久久| 青青国产线免观| 热99re久久精品天堂| 韩国主播av福利一区二区| 欧美国产一区二区三区激情无套 | 无码中文字幕在线播放2| 高清国产一区二区三区在线| av无码人妻中文字幕| 亚洲一区二区三区偷拍女厕| 狠狠色狠狠色综合久久| 国产成人av片无码免费| 亚洲人色婷婷成人网站在线观看| 成人无码www免费视频| 久久香综合精品久久伊人| 亚洲精品国男人在线视频| 天天躁日日躁狠狠躁一区| 青青草国产精品日韩欧美| 国产精品白丝av网站| 久久久久久久97| 少妇愉情理伦片丰满丰满午夜| 婷婷综合缴情亚洲狠狠| 成人毛片18女人毛片免费| 欧美破苞系列二十三| 婷婷综合缴情亚洲狠狠| 毛片免费视频在线观看|