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  4. Recombinant Human E3 ubiquitin-protein ligase RNF43 (RNF43), partial

Recombinant Human E3 ubiquitin-protein ligase RNF43 (RNF43), partial

  • 中文名稱：
    Recombinant Human E3 ubiquitin-protein ligase RNF43 (RNF43), partial
  • 貨號：
    CSB-MP019892HU
  • 規(guī)格：
    ￥828
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 95% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 來源：
    Mammalian cell
  • 分子量：
    20.4 kDa
  • 表達(dá)區(qū)域：
    24-197aa
  • 氨基酸序列
    GFGRTGLVLAAAVESERSAEQKAIIRVIPLKMDPTGKLNLTLEGVFAGVAEITPAEGKLMQSHPLYLCNASDDDNLEPGFISIVKLESPRRAPRPCLSLASKARMAGERGASAVLFDITEDRAAAEQLQQPLGLTWPVVLIWGNDAEKLMEFVYKNQKAHVRIELKEPPAWPDY
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    C-terminal 10xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification.
  • 基因功能參考文獻(xiàn)：
    1. results establish that RSPO2, without the LGR4/5/6 receptors, serves as a direct antagonistic ligand to RNF43 and ZNRF3, which together constitute a master switch that governs limb specification; these findings have direct implications for regenerative medicine and WNT-associated cancers PMID: 29769720
    2. Data suggest that inactivation of RNF43 and ZNRF3 is important in serrated tumorigenesis and has identified a potential therapeutic strategy for this cancer subtype. PMID: 27661107
    3. Chimeric transcript resulting from the fusion of RNF43 and SUPT4H1 was found to occur frequently in primary colorectal carcinoma. PMID: 27461012
    4. RNF43 mutation constitutes an important mutated driver gene for the Serrated Neoplasia pathway in both the sporadic and familial Polyposis settings. PMID: 27329244
    5. RNF43 is down-regulated in intrahepatic cholangiocarcinoma and may play a crucial role during development of ICC. PMID: 26980022
    6. The finding of RNF43 mutation in sessile serrated adenoma and traditional serrated adenoma, but not in tubulovillous/villous adenoma, indicated that RNF43 mutation is an early and specific molecular aberration in the serrated colorectal carcinoma pathway. PMID: 27305845
    7. Mutations and downregulation of RNF43 may play a critical role in the transition from adenoma to carcinoma. PMID: 27514024
    8. PTPRK-RSPO3 fusions and RNF43 mutations were found to be characteristic genetic features of traditional serrated adenomas (TSAs). PMID: 26924569
    9. our study exhibited the expression patterns and correlation of RNF43 and p53 pathway proteins involved in cell cycling PMID: 26823834
    10. Authors also identified ring finger 43 (RNF43), an inhibitor of Wnt/beta-catenin signaling, as a target of miR-550a-5p. PMID: 25961913
    11. RNF43 inhibits the Wnt pathway downstream of oncogenic mutations that activate the pathway. PMID: 26350900
    12. RNF43 might act as a tumor suppressor in gastric carcinoma and might be a potential indicator for the clinical assessment of gastric cancer prognosis PMID: 26184844
    13. RNF43 gene harbored not only exceedingly high mutations but also mutational intratumoral heterogeneity, which together might play a role in tumorigenesis of gastric and colorectal cancers. PMID: 26297255
    14. The nucleoprotein of influenza A virus targets RNF43 to modulate p53 ubiquitination levels and hence causes p53 stabilization which is conducive to an enhanced apoptosis level in the host cells. PMID: 25996295
    15. we found that the decreased expression of RNF43 in glioma was associated with poor prognosis by the Kaplan-Meier survival analysis. Importantly, multivariate analysis suggested RN43 as an independent predictor of overall survival. PMID: 25755738
    16. These results indicate that RNF43 mutation might cause downregulation of the expression of ring finger protein 43 and play a crucial role during development of intraductal papillary mucinous neoplasm of the pancreas. PMID: 25081753
    17. Data indicate Dishevelled (DVL) as a dual function adaptor to recruit negative regulators ZNRF3/RNF43 to Wnt receptors to ensure proper control of pathway activity. PMID: 25891077
    18. Missense mutations of RNF43 change their localization from the endosome to the endoplasmic reticulum. PMID: 25825523
    19. RNF43 is one of the most commonly mutated genes in colorectal and endometrial cancers PMID: 25344691
    20. Signalling potency of R-spondin proteins depends on their ability to recruit ZNRF3 or RNF43 via Fu1 into a complex with LGR receptors, which interact with Rspo via Fu2 PMID: 24225776
    21. RNF43 mutations are recurrent in Chinese patients with mucinous ovarian carcinoma but absent in other subtypes of ovarian cancer. PMID: 24001777
    22. mutational inactivation of RNF43 in pancreatic adenocarcinoma confers Wnt dependency PMID: 23847203
    23. RNF43 is involved in tumorigenesis and progression of human hepatocellular carcinoma. PMID: 23136185
    24. RNF43 is a tumour suppressor gene mutated in mucinous tumours of the ovary. PMID: 23096461
    25. RNF43 and ZNRF3 reduce Wnt signals by selectively ubiquitinating frizzled receptors, thereby targeting these Wnt receptors for degradation PMID: 22895187
    26. These findings suggest that RNF43 is associated with p53-mediated apoptosis in collaboration with NEDL1 in colorectal carcinogenesis. PMID: 21108931
    27. RNF43 may exert its growth promoting effect in an antocrine manner and may be a novel diagnostic marker for colorectal cancer PMID: 15492824
    28. These results infer that RNF43 is a resident protein of the ER and, at least partially, the nuclear membrane, with ubiquitin ligase activity and may be involved in cell growth control potentially through the interaction with HAP95. PMID: 18313049

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  • 相關(guān)疾病：
    Sessile serrated polyposis cancer syndrome (SSPCS)
  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Nucleus envelope.
  • 蛋白家族：
    ZNRF3 family
  • 組織特異性：
    Expressed in fetal kidney, fetal lung, in colon cancer tissues, hepatocellular carcinomas and lung adenocarcinomas. Overexpressed in colorectal cancer cell lines.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18505

    OMIM: 612482

    KEGG: hsa:54894

    STRING: 9606.ENSP00000385328

    UniGene: Hs.584916



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