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  4. Recombinant Human E3 ubiquitin-protein ligase RNF115 (RNF115 ZNF364)

Recombinant Human E3 ubiquitin-protein ligase RNF115 (RNF115 ZNF364)

  • 中文名稱：
  • 貨號(hào)：
    CSB-YP875171HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
  • 貨號(hào)：
    CSB-EP875171HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
  • 貨號(hào)：
    CSB-EP875171HU-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
  • 貨號(hào)：
    CSB-BP875171HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
  • 貨號(hào)：
    CSB-MP875171HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    RN115
  • Uniprot No.：
  • 別名：
    E3 ubiquitin-protein ligase RNF115; EC 2.3.2.27; RING finger protein 115; RING-type E3 ubiquitin transferase RNF115; Rab7-interacting RING finger protein; Rabring 7; Zinc finger protein 364; RNF115 ZNF364
  • 種屬：
    Homo sapiens (Human)
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates and may play a role in diverse biological processes. Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4.
  • 基因功能參考文獻(xiàn)：
    1. Results from a study on gene expression variability markers in early-stage human embryos shows that RNF115 is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
    2. Specifically, BCA2 serves as an E3 SUMO ligase in the SUMOylation of IkappaBalpha, which in turn enhances the sequestration of NF-kappaB components in the cytoplasm. Since HIV-1 utilizes NF-kappaB to promote proviral transcription, the BCA2-mediated inhibition of NF-kappaB significantly decreases the transcriptional activity of HIV-1. PMID: 28122985
    3. BCA2 functions as an antiviral factor that targets HIV-1 Gag for degradation, impairing virus assembly and release. PMID: 24852021
    4. BCA2 is an endogenous inhibitor of AMPK activation in breast cancer cells and BCA2 inhibition increases the efficacy of metformin. PMID: 24403860
    5. BCA2, a potential oncogenic E3 ubiquitin ligase, promotes breast cancer cell proliferation partially through targeting p21 for ubiquitination and proteasomal degradation. PMID: 24027428
    6. RNF126 and Rabring7 play a role in the ubiquitin-dependent sorting and downregulation of membrane receptors. PMID: 23418353
    7. High BCA2 expression is associated with renal oncocytoma. PMID: 23242606
    8. BCA2 is therefore a newly identified transcriptional target of estrogen receptor. PMID: 22850893
    9. Rabring7 stimulates c-Myc degradation via mono-ubiquitination of MM-1 PMID: 22844532
    10. BCA2 accelerates the internalization and degradation of viral particles following their tethering to the cell surface and is a co-factor or enhancer for the tetherin-dependent restriction of HIV-1 release from infected cells. PMID: 20019814
    11. BCA2 E3 ligase is coregulated with estrogen receptor and plays a role in the regulation of epidermal growth factor receptor (EGF-R) trafficking PMID: 16925951
    12. These results suggest that Rabring7 is involved in the endocytic trafficking of EGFR through its E3 ligase activity. PMID: 17462600
    13. The autoubiquitination activity of BCA2 indicates that it is a novel RING-type E3 ligase. PMID: 16288031

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  • 亞細(xì)胞定位：
    Cytoplasm, cytosol.
  • 組織特異性：
    Expressed at extremely low levels in normal breast, prostate, lung, colon. Higher levels of expression are detected in heart, skeletal muscle, testis as well as in breast and prostate cancer cells.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18154

    KEGG: hsa:27246

    STRING: 9606.ENSP00000358297

    UniGene: Hs.523550



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