在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human E3 ubiquitin-protein ligase FANCL (FANCL)

Recombinant Human E3 ubiquitin-protein ligase FANCL (FANCL)

  • 中文名稱：
    人FANCL重組蛋白
  • 貨號：
    CSB-YP882120HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人FANCL重組蛋白
  • 貨號：
    CSB-EP882120HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人FANCL重組蛋白
  • 貨號：
    CSB-EP882120HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人FANCL重組蛋白
  • 貨號：
    CSB-BP882120HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人FANCL重組蛋白
  • 貨號：
    CSB-MP882120HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    E3 ubiquitin-protein ligase FANCL; FAAP43; Fancl; FANCL_HUMAN; Fanconi anemia complementation group L; Fanconi anemia group L protein; Fanconi anemia-associated polypeptide of 43 kDa; FLJ10335; PHD finger protein 9; PHF9; POG; Ubiquitin ligase protein FANCL
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    2-375
  • 氨基酸序列
    AVTEASLLR QCPLLLPQNR SKTVYEGFIS AQGRDFHLRI VLPEDLQLKN ARLLCSWQLR TILSGYHRIV QQRMQHSPDL MSFMMELKML LEVALKNRQE LYALPPPPQF YSSLIEEIGT LGWDKLVYAD TCFSTIKLKA EDASGREHLI TLKLKAKYPA ESPDYFVDFP VPFCASWTPQ SSLISIYSQF LAAIESLKAF WDVMDEIDEK TWVLEPEKPP RSATARRIAL GNNVSINIEV DPRHPTMLPE CFFLGADHVV KPLGIKLSRN IHLWDPENSV LQNLKDVLEI DFPARAILEK SDFTMDCGIC YAYQLDGTIP DQVCDNSQCG QPFHQICLYE WLRGLLTSRQ SFNIIFGECP YCSKPITLKM SGRKH
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Ubiquitin ligase protein that mediates monoubiquitination of FANCD2 in the presence of UBE2T, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCI. May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth.
  • 基因功能參考文獻：
    1. A novel homozygous mutation c.822_823insCTTTCAGG (p.Asp275LeufsX13) in the FANCL gene identified in a Chinese patient with Fanconi anemia. PMID: 28419882
    2. Using small interfering RNA (siRNA), knockdown of FANCF, FANCL, or FANCD2 inhibited function of the FA/BRCA pathway in A549, A549/DDP and SK-MES-1 cells, and potentiated sensitivity of the three cells to cisplatin. PMID: 26385482
    3. Loss-of-Function FANCL Mutations Associate with Severe Fanconi Anemia Overlapping the VACTERL Association PMID: 25754594
    4. a signal transduction pathway involved in self-renewal and survival of hematopoietic stem cells also functions to stabilize FANCL and suggesting that FANCL participates directly in support of stem cell function. PMID: 23783032
    5. FAVL elevation can increase the tumorigenic potential of bladder cancer cells, including the invasive potential that confers the development of advanced bladder cancer. PMID: 22828653
    6. Suppression of FANCL expression in normal CD34(+) stem and progenitor cells results in fewer beta-catenin active cells and inhibits expansion of multilineage progenitors. PMID: 22653977
    7. FA DNA repair genes, FANCD2, FANCL, and FANCC, are transcriptionally upregulated differently in melanoma compared with non-melanoma skin cancer PMID: 21697891
    8. genetic diversity in FANCA, FANCC and FANCL does not support an association of these genes with cervical cancer susceptibility in the Swedish population. PMID: 21543111
    9. FANCL is associated with acute lung injury in mice PMID: 21297076
    10. expression of a novel splice variant of FA complementation group L (FANCL), named FAVL, can impair the FA pathway in non-FA tumor cells and act as a tumor promoting factor PMID: 20407210
    11. data suggest that PHF9 has a crucial role in the Fanconi anemia pathway as the likely catalytic subunit required for monoubiquitination of FANCD2 PMID: 12973351
    12. FANCL, via its WD40 region, binds the FA complex and, via its PHD, recruits an as-yet-unidentified E2 for mono-ubiquitination of FANCD2 PMID: 16474167
    13. Abnormal FANCL expression is the cause leading to a defective Ranconi anemia-BRCA pathway, conferring sensitivity of a lung cancer cell line to mitomycin C> PMID: 17106252
    14. the first report to describe hypermethylation of FANCC in leukemia PMID: 18607065
    15. Upon the occurrence of DNA damage, FANCI becomes monoubiquitinated on Lys-523 by the UBE2T-FANCL pair. PMID: 19589784
    16. results rule out a major role of FANCL in familial breast cancer susceptibility PMID: 19737859
    17. FANCL is necessary for primordial germ cell proliferation during the embryonic stage but not necessary for spermatogonia proliferation in adulthood. Thus, mouse FancL-/- males are infertile at 7 to 12 weeks but gain fertility thereafter. PMID: 12606378
    18. Deficiency of Fancl (also called Pog) is the cause of gcd mouse, which has a reduced number of primordial germ cells during the embryonic stage. PMID: 12417526

    顯示更多

    收起更多

  • 相關疾病：
    Fanconi anemia complementation group L (FANCL)
  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 數據庫鏈接：

    HGNC: 20748

    OMIM: 608111

    KEGG: hsa:55120

    STRING: 9606.ENSP00000385021

    UniGene: Hs.631890



主站蜘蛛池模板： 夜夜躁日日躁狠狠久久av| 精品无码国产日韩制服丝袜| 露脸内射熟女--69xx| 欧美人妻aⅴ中文字幕| 国产精品理论片在线观看| 国厂精品114福利电影免费| 国产精品午夜剧场免费观看| 人人妻人人澡人人爽欧美一区双| 欧美大屁股xxxxhd黑色| 久久亚洲中文字幕精品一区 | 97国产精品人妻无码久久久| 人妻丰满熟妇av无码处处不卡| 伊人99综合精品视频| 久久久国产打桩机| 永久免费精品精品永久-夜色| 啪啪激情婷婷久久婷婷色五月| 久久国产亚洲高清观看| 精品乱码一区内射人妻无码| 日本丰满护士bbw| 成在人线av无码免费看网站直播| 国产无遮挡又黄又爽在线观看| 337p人体粉嫩胞高清视频| a在线亚洲男人的天堂| 亚洲精品美女久久777777| 欧美奶涨边摸边做爰视频| 久久精品国产一区二区三区| 国产美女久久精品香蕉| 亚洲中文字幕无码久久| 男阳茎进女阳道视频大全 | 亚洲人成伊人成综合网久久久| 色噜噜狠狠一区二区三区| 在线亚洲日产一区二区| 亚洲精品午夜久久久伊人| 欧美大胆少妇bbw| 久久久中文字幕日本无吗 | 亚州久久久久区1区2少妇| 人人妻人人澡人人爽| 国产精品无码日韩欧| av无码av在线a∨天堂app| 国产午夜片无码区在线播放| 日本三级手机在线播放线观看 |