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  4. Recombinant Human Dynamin-binding protein (DNMBP), partial

Recombinant Human Dynamin-binding protein (DNMBP), partial

  • 中文名稱：
    人DNMBP重組蛋白
  • 貨號：
    CSB-YP757862HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人DNMBP重組蛋白
  • 貨號：
    CSB-EP757862HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人DNMBP重組蛋白
  • 貨號：
    CSB-EP757862HU-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人DNMBP重組蛋白
  • 貨號：
    CSB-BP757862HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人DNMBP重組蛋白
  • 貨號：
    CSB-MP757862HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    DNMBP
  • Uniprot No.：
  • 別名：
    Dnmbp; DNMBP_HUMAN; Dynamin binding protein; Dynamin-binding protein; KIAA1010; Scaffold protein Tuba; TUBA
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

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靶點詳情

  • 功能：
    Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells. Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation. Plays a role in ciliogenesis. May play a role in membrane trafficking between the cell surface and the Golgi.
  • 基因功能參考文獻：
    1. The rs3740058 in DNMBP was significantly differently in genotype between Alaheimer diease and control in APOE epsilon4epsilon4 subgroup, but showed no effect on Alzheimer disease risk, either did rs11190305 polymorphisms in DNMBP. PMID: 25801238
    2. Cdc42 and its specific guanine nucleotide-exchange factor (GEF), Tuba, localize to linear invadosomes, and both are required for linear invadosome formation PMID: 25422375
    3. Polyproline region of N-WASP is required for the localization of Tuba at the pre-apical patch. PMID: 21677511
    4. findings underscore a role for DNMBP in the genetic risk for late-onset Alzheimer's disease in the Belgian population PMID: 18359537
    5. functions to bring together dynamin with actin regulatory proteins PMID: 14506234
    6. Results confirmed DNMBP may be one of the susceptibility genes for Alzheimer's disease. PMID: 16740596
    7. Tuba controls the shaping of cell junctions through the local activation of Cdc42 and its effectors. PMID: 17015620
    8. We observed no association of statistical significance in either the total sample or the APOE*4 non-carriers for any of the SNPs of Dynamin Binding Protein. PMID: 17442457
    9. Although DNMBP is an excellent candidate gene because of its role in the APP recycling pathways and being located within a chromosome 10 linkage region, we are unable to confirm that DNMBP is associated with LOAD PMID: 18452187

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  • 亞細胞定位：
    Cytoplasm. Golgi apparatus, Golgi stack. Cytoplasm, cytoskeleton. Cell junction, synapse. Cell junction.
  • 組織特異性：
    Detected in heart, brain, lung, liver, skeletal muscle, kidney and pancreas.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 30373

    OMIM: 611282

    KEGG: hsa:23268

    STRING: 9606.ENSP00000315659

    UniGene: Hs.500771



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