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  4. Recombinant Human Dynamin-3 (DNM3), partial

Recombinant Human Dynamin-3 (DNM3), partial

  • 中文名稱：
    人DNM3重組蛋白
  • 貨號：
    CSB-YP892494HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人DNM3重組蛋白
  • 貨號：
    CSB-EP892494HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人DNM3重組蛋白
  • 貨號：
    CSB-EP892494HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人DNM3重組蛋白
  • 貨號：
    CSB-BP892494HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人DNM3重組蛋白
  • 貨號：
    CSB-MP892494HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    testicular dynamin; testicular; DNM 3; DNM3; DNM3 protein; Dyn3; DYN3_HUMAN; Dyna III; DynaIII; dynamin 2 ; Dynamin; Dynamin family member; Dynamin testicular; Dynamin-3; Dynamin3; EC 3.6.5.5; KIAA0820; MGC70433; T dynamin; T-dynamin
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis.
  • 基因功能參考文獻：
    1. In glioma, elevated miR-221 expression is a biomarker for glioma. DNM3 is a target of miR-221 and RELA regulates miR-221 expression. PMID: 27837435
    2. Genetic variability in DNM3 modifies age of onset for LRRK2 Gly2019Ser parkinsonism. PMID: 27692902
    3. DNM3 may be involved in risk of obsessive-compulsive disorder. PMID: 27023174
    4. Microdeletion of DNM3 harboring miR199 and miR214 is associated with skeletal abnormalities. PMID: 26333682
    5. DNM3 attenuates the proliferation and induces apoptosis of gastric cancer cells. PMID: 26784388
    6. Data show that the classical dynamin DNM1 and DNM3 genes reach their maximum expression levels (100% of maximal expression) in all normal central nervous system tissues studied. PMID: 24673776
    7. Data indicate that dynamin 3 (DNM3) harbors MEIS1 binding sites and is associated with differences in mean platelet volume (MPV). PMID: 22972982
    8. DNM3 not only participates in megakaryocyte progenitor amplification, but is also involved in cytoplasmic enlargement and the formation of the demarcation membrane system. PMID: 21671749
    9. Dynamin GTPase regulation is altered by PH domain mutations found in centronuclear myopathy patients. PMID: 20700106
    10. dynamin-3 and the postsynaptic adaptor Homer positions the endocytic zones near the postsynaptic density PMID: 17880892
    11. Upon comparison of PBMC and skin samples of Sezary syndrome versus mycosis fungoides, CDO1 and DNM3 were found upregulated only in Sezary syndrome. PMID: 18033314
    12. Dynamin 3 participates in the growth and development of megakaryocytes. PMID: 19007685

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  • 亞細胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family
  • 數據庫鏈接：

    HGNC: 29125

    OMIM: 611445

    KEGG: hsa:26052

    STRING: 9606.ENSP00000350876

    UniGene: Hs.654775



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