在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Dual specificity protein phosphatase CDC14B (CDC14B)

Recombinant Human Dual specificity protein phosphatase CDC14B (CDC14B)

  • 中文名稱：
    Recombinant Human Dual specificity protein phosphatase CDC14B(CDC14B)
  • 貨號：
    CSB-YP004986HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Dual specificity protein phosphatase CDC14B(CDC14B)
  • 貨號：
    CSB-EP004986HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Dual specificity protein phosphatase CDC14B(CDC14B)
  • 貨號：
    CSB-EP004986HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Dual specificity protein phosphatase CDC14B(CDC14B)
  • 貨號：
    CSB-BP004986HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Dual specificity protein phosphatase CDC14B(CDC14B)
  • 貨號：
    CSB-MP004986HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    CC14B_HUMAN; Cdc 14B; Cdc 14B1; Cdc 14B2; CDC 14B3; CDC14 cell division cycle 14 homolog B; CDC14 homolog B; Cdc14b; Cdc14B1; Cdc14B2; CDC14B3; Cell division cycle 14 homolog B; Dual specificity protein phosphatase CDC14B; hCDC 14B; hCDC14B; OTTHUMP00000063774
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-498
  • 氨基酸序列
    MKRKSERRSS WAAAPPCSRR CSSTSPGVKK IRSSTQQDPR RRDPQDDVYL DITDRLCFAI LYSRPKSASN VHYFSIDNEL EYENFYADFG PLNLAMVYRY CCKINKKLKS ITMLRKKIVH FTGSDQRKQA NAAFLVGCYM VIYLGRTPEE AYRILIFGET SYIPFRDAAY GSCNFYITLL DCFHAVKKAM QYGFLNFNSF NLDEYEHYEK AENGDLNWII PDRFIAFCGP HSRARLESGY HQHSPETYIQ YFKNHNVTTI IRLNKRMYDA KRFTDAGFDH HDLFFADGST PTDAIVKEFL DICENAEGAI AVHCKAGLGR TGTLIACYIM KHYRMTAAET IAWVRICRPG SVIGPQQQFL VMKQTNLWLE GDYFRQKLKG QENGQHRAAF SKLLSGVDDI SINGVENQDQ QEPEPYSDDD EINGVTQGDR LRALKSRRQS KTNAIPLTVI LQSSVQSCKT SEPNISGSAG ITKRTTRSAS RKSSVKSLSI SRTKTVLR
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases.
  • 基因功能參考文獻：
    1. The authors found a significant association between the localization of RET mutations and the expression of three genes: NNAT (suggested to be a tumour suppressor gene), CDC14B (involved in cell cycle control) and NTRK3 (tyrosine receptor kinase that undergoes rearrangement in papillary thyroid cancer) in patients with medullary thyroid cancer. PMID: 28181547
    2. hCdc14B promotes reactivation of rDNA transcription by dephosphorylating TAFI110. SIRT1 becomes transiently enriched in nucleoli at the onset of mitosis. SIRT1 deacetylates TAFI68 destabilizing SL1 binding to the rDNA promoter PMID: 26023773
    3. CDC14B expression is downregulated in clear cell renal carinoma, suggesting its role in renal carcinogenesis PMID: 24619757
    4. CDC (cell division cycle) 14A/B phosphatases associate with KIBRA, and CDK1-non-phosphorylatable KIBRA has greatly reduced interaction with CDC14B. PMID: 22784093
    5. studies have revealed a novel interplay between Chk1 kinase and Cdc14B phosphatase involving radiation-induced nucleolar shuttling to facilitate error-free cell cycle progression and prevent genomic instability PMID: 21301228
    6. Cdc14B-dependent modulation of Cdc25 phosphatase and Cdk1/cyclin B activity is linked to correct chromosome segregation and bipolar spindle formation, processes that are required for proper progression through mitosis and maintenance of genomic stability. PMID: 21379580
    7. human HCT116, and human telomerase reverse transcription-immortalized retinal pigment epithelial cells deleted for Cdc14B are DNA damage checkpoint proficient and arrest efficiently in G2 in response to irradiation. PMID: 20479464
    8. Cdc14B is critical for the maintenance of proper nuclear structure. PMID: 15362113
    9. CDC14B is a novel microtubule-bundling and -stabilizing protein, whose regulated subcellular localization may help modulate spindle and microtubule dynamics in mitosis. PMID: 15899858
    10. hCdc14A and hCdc14B have functional homology to S. pombe Cdc25 and flp1 PMID: 15911625
    11. Our findings reveal substantial divergence in mitotic regulation between yeast and mammalian cells, as the latter possess efficient mechanisms for completing late M-phase events in the absence of a nucleolar Cdc14-related phosphatase. PMID: 18418058
    12. Results suggest a potential function for Cdc14B phosphatase in maintaining the fidelity of centrosome duplication cycle. PMID: 18458157
    13. In response to genotoxic stress in G2, the phosphatase Cdc14B translocates from the nucleolus to the nucleoplasm and induces the activation of the ubiquitin ligase APC/C(Cdh1), with the consequent degradation of Plk1, a prominent mitotic kinase. PMID: 18662541

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Following DNA damage, translocates from the nucleolus to the nucleoplasm and interacts with FZR1/CDH1.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class CDC14 subfamily
  • 數據庫鏈接：

    HGNC: 1719

    OMIM: 603505

    KEGG: hsa:8555

    STRING: 9606.ENSP00000364389

    UniGene: Hs.40582



主站蜘蛛池模板： 亚洲中文字幕无码卡通动漫野外| 丁香婷婷无码不卡在线| 亚洲香蕉aⅴ视频在线播放| 中文字幕aav| 国产成人综合一区人人| 亚洲乱色熟女一区二区三区丝袜| 国产午精品午夜福利757视频播放| 涩里番网污站| 国内精品久久久久久久电影视| 国产成人av在线影院无毒| 国产乱人伦精品免费| 欧美日韩精品一区二区在线播放| 亚洲天堂男人影院| 国产精品国产免费无码专区不卡| 国产人妻人伦精品1国产| 熟女人妻av粗壮巨龙| 国产sm鞭打折磨调教视频| 国产高清在线精品一区二区三区| 都市激综合小说区另类区| 青青草大香焦在线综合视频| 亚洲综合无码一区二区三区| 人人妻一区二区三区| 久天啪天天久久99久久 | 琪琪秋霞午夜av影视在线| 国产农村乱子伦精品视频| 免费观看又污又黄的网站| 国产精品天干天干有线观看| 亚无码乱人伦一区二区| 国产日产欧产精品精品免费| 2022国产日产欧产精品| 国产午夜福利在线观看视频| 亚洲一区二区三区av无码| 亚洲美女国产精品久久久久久久久 | 在线播放人成视频观看| 国厂精品114福利电影免费| 国产乱视频在线观看| 亚洲国产精品嫩草影院| 国产综合色在线精品| 狠狠色丁香久久婷婷综合蜜芽五月| 麻豆精品人妻一区二区三区蜜桃| 黑人大荫蒂高潮视频|