在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Disintegrin and metalloproteinase domain-containing protein 22 (ADAM22), partial

Recombinant Human Disintegrin and metalloproteinase domain-containing protein 22 (ADAM22), partial

  • 中文名稱：
    Recombinant Human Disintegrin and metalloproteinase domain-containing protein 22(ADAM22),partial
  • 貨號：
    CSB-YP865198HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Disintegrin and metalloproteinase domain-containing protein 22(ADAM22),partial
  • 貨號：
    CSB-EP865198HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Disintegrin and metalloproteinase domain-containing protein 22(ADAM22),partial
  • 貨號：
    CSB-EP865198HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Disintegrin and metalloproteinase domain-containing protein 22(ADAM22),partial
  • 貨號：
    CSB-BP865198HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Disintegrin and metalloproteinase domain-containing protein 22(ADAM22),partial
  • 貨號：
    CSB-MP865198HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ADAM22
  • Uniprot No.：
  • 別名：
    A disintegrin and metalloproteinase domain 22; ADA22_HUMAN; ADAM 22; ADAM metallopeptidase domain 22; adam22; and cysteine-rich protein 2; Disintegrin and metalloproteinase domain-containing protein 22; disintegrin-like; MDC 2; MDC2; Metalloproteinase disintegrin ADAM22 3; Metalloproteinase like disintegrin like and cysteine rich protein 2; Metalloproteinase-disintegrin ADAM22-3; Metalloproteinase-like; MGC149832
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1.
  • 基因功能參考文獻：
    1. the LGI1-ADAM22 complex functions as the trans-synaptic machinery for precise synaptic transmission PMID: 29670100
    2. ADAM22 is critically involved in miR-449a-reduced tamoxifen resistance of estrogen receptor-positive breast cancer cells as a direct target of miR-449a. PMID: 30278449
    3. these results support the existence of a second mechanism, alternative to inhibition of protein secretion, by which ADLTE-causing LGI1 mutations exert their loss-of-function effect extracellularly, and suggest that interactions of LGI1 with both ADAM22 and ADAM23 play an important role in the molecular mechanisms leading to utosomal dominant lateral temporal epilepsy PMID: 27760137
    4. Disruption of LGI1-ADAM22 interaction reduces synaptic AMPA receptors in hippocampal neurons. PMID: 24227725
    5. Data suggest that ADAM22 plays roles in cell differentiation, cell migration, and resistance to endocrine therapy in breast cancer; ADAM22 may serve as biomarker for poor disease-free survival in breast cancer patients. [REVIEW] PMID: 23810013
    6. findings suggest that SRC-1 switches steroid-responsive tumors to a steroid-resistant state in which the SRC-1 target gene ADAM22 has a critical role PMID: 22072566
    7. Mutations in disintegrin domain sequence in ADAM22 gene is associted with reduced LGI4-binding abilities resulting in epilepsy. PMID: 20156119
    8. Transgenic leucine-rich glioma-inactivated 4 (Lgi4) and transgenic Adam22 proteins are both expressed in Schwann cells as well as in sensory neurons; binding of Lgi4 to axonal Adam22 is required on axons to drive myelin formation. PMID: 20220021
    9. role for the 14-3-3zeta/ADAM 22 association in the regulation of cell adhesion and related signaling events PMID: 12589811
    10. demonstrated a functional role for ADAM22/14-3-3 in cell adhesion and spreading PMID: 15882968
    11. ADAM22, a brain-specific cell surface protein, mediates growth inhibition using an integrin dependent pathway. It is expressed in normal brain but not in high-grade gliomas. PMID: 16385342
    12. This study indicated ADAM22 gene is probably not a major gene for this epilepsy syndrome. PMID: 17681454
    13. Differential coding potential of ADAM22 mRNAs. PMID: 17884303
    14. our results suggest that neither ADAM22 nor any of the three Kv1 channel genes are major causative genes for ADLTE. PMID: 18440780
    15. The pro domains of ADAMs are expressed as two subdomains. The most N-terminal subdomain (ADAM22-P(N)) was found to be susceptible to proteolysis and was required for folding stability of the second subdomain (ADAM22-P(C)). PMID: 18593599

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell projection, axon.
  • 組織特異性：
    Highly expressed in the brain and in some high-grade but not low-grade gliomas. Detected slightly or not at all in other tissues.
  • 數據庫鏈接：

    HGNC: 201

    OMIM: 603709

    KEGG: hsa:53616

    STRING: 9606.ENSP00000265727

    UniGene: Hs.256398



主站蜘蛛池模板： 亚洲性啪啪无码av天堂| 69久久精品无码一区二区无码| 亚洲中文字幕无码日韩精品| 国产农村熟妇videos| 精品人妻一区二区三区四区在线| 又爽又色禁片1000视频免费看| 国产成人av在线一区二区三区 | 亚洲精品无码不卡在线播放he| 欧美日韩亚洲国产在线制服 | 欧美国产日韩a在线视频下载| 无码日韩人妻精品久久蜜桃| 国产精品久久福利网站| 少妇和邻居做不戴套视频| 亚洲六月丁香六月婷婷| 亚洲熟妇无码av在线播放| 亚洲精品乱码久久久久久蜜桃不卡| 久久婷婷狠狠综合激情| 无套内射在线观看theporn| 脱了美女内裤猛烈进入gif| 国产精品无码专区久久久| 色94色欧美sute亚洲线路一| 亚洲精品久久久久久中文传媒| 天堂网在线最新版www资源网| 国产真实偷乱视频| 久久精品亚洲综合专区 | 国产精品成人va在线观看| 人妻无码中文字幕一区二区三区| 少妇被黑人4p到惨叫欧美人| 亚洲成a v人片在线观看| 国产成人精品白浆久久69| 午夜福利影院私人爽爽| 亚洲国产成人第一天堂| 高级会所人妻互换94部分| 亚洲337少妇裸体艺术| 欧美国产亚洲日韩在线二区| 亚洲 欧美 变态 另类 综合| 欧美一区二区三区视频在线观看 | 久久综合久久久久88| 久久久无码精品午夜| 久久理论片午夜琪琪电影网| 搡女人真爽免费视频大全|