在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Dimethyladenosine transferase 1, mitochondrial (TFB1M)

  • 中文名稱:
    人TFB1M重組蛋白
  • 貨號:
    CSB-YP023420HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人TFB1M重組蛋白
  • 貨號:
    CSB-EP023420HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人TFB1M重組蛋白
  • 貨號:
    CSB-EP023420HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人TFB1M重組蛋白
  • 貨號:
    CSB-BP023420HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人TFB1M重組蛋白
  • 貨號:
    CSB-MP023420HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    TFB1M
  • Uniprot No.:
  • 別名:
    N'-adenosyl(rRNA) dimethyltransferase 1; CGI75; Dimethyladenosine transferase 1; mitochondrial; h-mtTFB; h-mtTFB1; hmtTFB; hmtTFB1; hTFB1M; Mitochondrial 12S rRNA dimethylase 1; Mitochondrial dimethyladenosine transferase 1; Mitochondrial transcription factor B1; mtTFB1; S-adenosylmethionine-6-N'; Tfb1m; TFB1M_HUMAN; Transcription factor B1 mitochondrial
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    28-346
  • 氨基酸序列
    QAA KQLSQNFLLD LRLTDKIVRK AGNLTNAYVY EVGPGPGGIT RSILNADVAE LLVVEKDTRF IPGLQMLSDA APGKLRIVHG DVLTFKVEKA FSESLKRPWE DDPPNVHIIG NLPFSVSTPL IIKWLENISC RDGPFVYGRT QMTLTFQKEV AERLAANTGS KQRSRLSVMA QYLCNVRHIF TIPGQAFVPK PEVDVGVVHF TPLIQPKIEQ PFKLVEKVVQ NVFQFRRKYC HRGLRMLFPE AQRLESTGRL LELADIDPTL RPRQLSISHF KSLCDVYRKM CDEDPQLFAY NFREELKRRK SKNEEKEEDD AENYRL
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity.
  • 基因功能參考文獻:
    1. Loss of TFB1M results in mitochondrial dysfunction that leads to impaired insulin secretion and diabetes. PMID: 24916378
    2. Deficiency in TFB1M and impaired mitochondrial function contribute to the pathogenesis of type 2 diabetes. PMID: 21195351
    3. The mRNA levels of TFB1M and TFB2M are influenced by endurance training PMID: 19681768
    4. This transcription factor activates transcription of human mitochondrial DNA. PMID: 12068295
    5. Human mitochondrial transcription factor B1 methylates ribosomal RNA at a conserved stem-loop PMID: 12496758
    6. TFB1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity PMID: 12897151
    7. TFB1M is a nuclear-encoded modifier gene for phenotypic expression of the deafness-associated homoplasmic A1555G mutation in the mitochondrial 12S rRNA gene. PMID: 15110318
    8. Distinct, but possibly coordinated functions of mtTFB1 and mtTFB2 in mitochondrial gene expression and biogenesis. PMID: 17557812
    9. This study suggested that DNA variants in TFB1M did not contribute to the risk for parkinson disease. PMID: 18980857
    10. determined the variation in the TFAM, TFB1M, and TFB2M genes in cardiac hypertrophy PMID: 19096125
    11. rRNA methyltransferase activity is necessary for induction of mitochondrial biogenesis by TFB1M, but not TFB2M. PMID: 19417006

    顯示更多

    收起更多

  • 相關疾病:
    Variations in TFB1M may influence the clinical expression of aminoglycoside-induced deafness caused by the A1555G mutation in the mitochondrial 12S rRNA.
  • 亞細胞定位:
    Mitochondrion.
  • 蛋白家族:
    Class I-like SAM-binding methyltransferase superfamily, rRNA adenine N(6)-methyltransferase family, KsgA subfamily
  • 組織特異性:
    Ubiquitously expressed.
  • 數據庫鏈接:

    HGNC: 17037

    OMIM: 607033

    KEGG: hsa:51106

    STRING: 9606.ENSP00000356134

    UniGene: Hs.279908



主站蜘蛛池模板: 2021亚洲国产成a在线| 中文国产乱码在线人妻一区二区| 天堂在/线中文在线资源 官网| 人妻系列无码一区二区三区| 欧美黑人又粗又大久久久| 无码日韩精品一区二区免费| 四虎影视在线影院在线观看| 日本一区二区无卡高清视频| 婷婷丁香五月缴情视频| 精品一区二区三区在线成人| 国产成人免费ā片在线观看老同学| 久久精品国产久精国产果冻传媒| 国产av一二三无码影片| 啦啦啦www播放日本观看| 少妇无套内谢久久久久| 国产午夜福利在线播放87| 亚洲国产精品无码中文字2022| 成人综合伊人五月婷久久| 亚洲大乳高潮日本专区| 人妻中出无码一区二区三区| 国产做a爰片久久毛片a片| 人人妻人人爽人人做夜欢视频| 8x福利精品第一导航| 在线视+欧美+亚洲日本| 欧亚乱熟女一区二区在线| 成人欧美一区二区三区在线| 国产好吊看视频在线观看| 性欧美老妇另类xxxx| 国产在视频线精品视频| 免费人成视频在线观看不卡| 国产亚洲精品久久一区二区| 中文字幕乱码亚洲无线三区 | 亚洲kkk4444在线观看| 五十路熟女一区二区三区| 亚洲男同志网站| 国产卡二卡三卡四卡免费网址| 国产成人精品免费午夜app| 中文字幕日产无码| 人妻少妇精品专区性色av| 日韩精品无码去免费专区| 深夜福利视频在线播放|