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  4. Recombinant Human DNA ligase 3 (LIG3), partial

Recombinant Human DNA ligase 3 (LIG3), partial

  • 中文名稱：
    人LIG3重組蛋白
  • 貨號：
    CSB-YP012931HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人LIG3重組蛋白
  • 貨號：
    CSB-EP012931HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人LIG3重組蛋白
  • 貨號：
    CSB-EP012931HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人LIG3重組蛋白
  • 貨號：
    CSB-BP012931HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人LIG3重組蛋白
  • 貨號：
    CSB-MP012931HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    D11Wsu78e; DNA ligase ; DNA ligase 3; DNA ligase III; DNLI3_HUMAN; LIG 3; LIG2; LIG3; Ligase II; DNA; ATP dependent; Ligase III DNA ATP dependent; MGC78176; OTTMUSP00000000875; Polydeoxyribonucleotide synthase [ATP] 3; Polydeoxyribonucleotide synthase [ATP]; Polydeoxyribonucleotide synthase; RP23-316C11.6
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair.
  • 基因功能參考文獻：
    1. The homozygotes of rs1052536 TT were associated with an increased risk for NTDs than CC, and variants of rs1052536 T were associated with an increased risk of Neural Tube Defects. The stratified analysis showed that TT genotype of rs1052536 increased the risk of anencephaly and the T allele significantly increased the risk of cranial Neural Tube Defects. PMID: 30022792
    2. single-stranded break repair by human DNA ligase III isoforms reveal biochemical differences from DNA ligase I PMID: 28751376
    3. The g.29661G>A and g.29059C>T polymorphisms of LIG3 may play a role in the keratoconus and Fuchs endothelial corneal dystrophy pathogenesis and can be considered as markers in these diseases. PMID: 25817347
    4. A computational approach to determine susceptibility to cancer by evaluating the deleterious effect of nsSNP in XRCC1 gene on binding interaction of XRCC1 protein with ligase III. PMID: 26449312
    5. In the context of tyrosine kinase-activated leukemias, c-MYC contributes to aberrant DNA repair through downstream targets LIG3 and PARP1 up-regulation. PMID: 25828893
    6. Domains constituting the LigIII catalytic core collaborate and are essential for formation of a DNA-bridging intermediate by adenylated LigIII that positions a pair of blunt-ended duplex DNAs for efficient and specific intermolecular ligation. PMID: 26130724
    7. there is an absolute requirement for fully functional DNA ligase III (LIG3), but not ligase IV (LIG4), to facilitate the escape from a telomere-driven crisis. PMID: 25127141
    8. LIGIII plays a role in additional EJing repair pathway only in the absence of Ku. PMID: 24837021
    9. Results show that overexpression of DNA ligase III in mitochondria improves mitochondrial base excision repair and enhances cell survival after oxidative stress. PMID: 24674627
    10. data confirm previous work showing that Lig3 is required to maintain mtDNA integrity and function, and highlight a new function of ATM in regulating DNA Lig3 stability and consequently mtDNA repair PMID: 24342190
    11. Human Mre11/human Rad50/Nbs1 and DNA ligase IIIalpha/XRCC1 protein complexes act together in an alternative nonhomologous end joining pathway. PMID: 21816818
    12. Using our cohort of 480 breast cancer patients, we provide replicated evidence that a polymorphism near the LIG3 gene is associated with acute skin toxicity following radiotherapy. PMID: 21620500
    13. results establish a role for Lig3 in mitochondria, but distinguish it from its interacting protein Xrcc1 PMID: 21390132
    14. The collective results support a "jackknife model" in which the ZnF loads ligase III onto nicked DNA and conformational changes deliver DNA into the active site. PMID: 20518483
    15. The interaction with Lig3alpha is promoted by serine 81 that is located within a putative S/TQ site in the N-terminus domain of TDP1. PMID: 20009512
    16. calpain-mediated proteolysis of DNA ligase III plays an essential role in DNA damage-induced cell death in human cells PMID: 11994275
    17. In response to DNA damage, DNA ligase IIIalpha translocate from centrosomes to chromosomes. PMID: 15653642
    18. XRCC1 stimulates Pol beta strand displacement activity and releases inhibition of Pol beta by DNA-bound Lig III if ligation is prevented. PMID: 16442856
    19. the interaction of DNA ligase III and DNA polymerase gamma is required for proper maintenance of the mammalian mitochondrial genome. PMID: 17054425
    20. Results describe the activity requirements for DNA ligases III and IV in the pathways of non-homologous DNA end joining. PMID: 17492771
    21. key role for XRCC1-DNA ligase IIIalpha in maintenance of genomic integrity by nucleotide excision repair in both dividing and nondividing cells PMID: 17643379
    22. analysis of DNA-binding and nick recognition modules in human DNA ligase III PMID: 18238776
    23. Data show that CHIP-mediated degradation and DNA damage-dependent stabilization regulate base excision repair proteins XRCC1, DNA polymerase beta, and DNA ligase III. PMID: 18313385
    24. siRNA mediated down-regulation of DNA ligase III in human HTD114 cells led to impaired end joining that was mediated by 2-, 3- or 10-bp microhomology. PMID: 18440984
    25. altered DNA double-strand break repair in CML cells is caused by the increased activity of an alternative nonhomologous end-joining repair pathway, involving DNA ligase IIIalpha and WRN PMID: 18524993
    26. PMID 10207110 showed that translation initiation at the first ATG in the cDNA can lead to a mitochondrially-targeted isoform of the protein. PMID: 10207110

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  • 亞細胞定位：
    [Isoform 1]: Mitochondrion.; [Isoform 2]: Mitochondrion.; [Isoform 3]: Nucleus.; [Isoform 4]: Nucleus.
  • 蛋白家族：
    ATP-dependent DNA ligase family
  • 組織特異性：
    Testis, thymus, prostate and heart.
  • 數據庫鏈接：

    HGNC: 6600

    OMIM: 600940

    KEGG: hsa:3980

    STRING: 9606.ENSP00000367787

    UniGene: Hs.100299



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