在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human DNA damage-regulated autophagy modulator protein 1 (DRAM1), partial

Recombinant Human DNA damage-regulated autophagy modulator protein 1 (DRAM1), partial

  • 中文名稱：
    人DRAM1重組蛋白
  • 貨號：
    CSB-YP836675HU1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人DRAM1重組蛋白
  • 貨號：
    CSB-EP836675HU1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人DRAM1重組蛋白
  • 貨號：
    CSB-EP836675HU1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人DRAM1重組蛋白
  • 貨號：
    CSB-BP836675HU1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人DRAM1重組蛋白
  • 貨號：
    CSB-MP836675HU1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    DRAM1
  • Uniprot No.：
  • 別名：
    DRAM1; DRAM; DNA damage-regulated autophagy modulator protein 1; Damage-regulated autophagy modulator
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy.
  • 基因功能參考文獻：
    1. Altogether, these findings suggest that in normal/high glucose condition a mutual unbalance between p53-dependent apoptosis (PUMA) and autophagy (DRAM) gene occurred, modifying the ADR-induced cancer cell death in HG both in vitro and in vivo. PMID: 28893313
    2. Overexpression of full-length AIFM1 suppresses proliferation and induces apoptosis of HepG2 and Hep3B cells. Caspase 3 and DRAM are involved in full-length AIFM1-induced apoptosis in HepG2 and Hep3B cells. PMID: 29501488
    3. DRAM1 regulates apoptosis by inhibiting BAX degradation. PMID: 25633293
    4. DRAM1 mediates autophagic defense against a broader range of intracellular pathogens, since DRAM1 expression was also induced by the common bacterial endotoxin lipopolysaccharide. PMID: 24922577
    5. Suggest that promoting DRAM-mediated autophagy together with PI3K/AKT inhibition might be more effective for autophagy-based therapy in hepatoma. PMID: 24556693
    6. DRAM is an important gene for the enhancement of p53-dependent apoptosis. PMID: 24133622
    7. DRAM1 affects autophagy through lysosomal acidification, fusion of lysosomes with autophagosomes and clearance of autophagosomes. PMID: 23696801
    8. DRAM gene expression is down regulated by oxidative stress through the mediation of reactive oxygen species PMID: 23832602
    9. DRAM triggers lysosomal membrane permeabilization and cell death in CD4(+) T cells infected with HIV. PMID: 23658518
    10. these findings shed new light on the role of autophagy in GBM and reveal a novel function of the autophagy regulators DRAM1 and p62 in control of migration/invasion in cancer stem cells. PMID: 22525272
    11. Overexpression of miR-199a-5p inhibits DRAM1 and Beclin1 expression. PMID: 23337876
    12. p73-regulated DRAM-1 is functionally involved in neutrophil differentiation of acute promyelocytic leukemia cells. PMID: 22981223
    13. DRAM-1 encodes not just one mRNA, but a series of p53-inducible splice variants which are expressed at varying levels in multiple human and mouse cell lines. PMID: 22082963
    14. Overexpression of DRAM induces VRK1 downregulation and the opposite effect was observed by its knockdown. PMID: 21386980
    15. Collectively therefore, these studies not only report a stress-induced regulator of autophagy but also highlight the relationship of DRAM and autophagy to p53 function and damage-induced programmed cell death. PMID: 16839881
    16. DRAM links autophagy to p53 and programmed cell death. PMID: 17102582
    17. identified FLJ11259/DRAM as a p53-inducible member of a novel family of transmembrane proteins. FLJ11259/DRAM may be an important modulator of p53 responses in diverse tumor types. PMID: 17397945
    18. DRAM is activated by p53 which is required for the ability of p53 to induce autophagy and is also critical for the ability of p53 to induce programmed cell death. PMID: 19556885
    19. c-Jun NH2-terminal kinase as a novel mediator of DRAM protein regulation in Ewing sarcoma cells PMID: 19706754

    顯示更多

    收起更多

  • 亞細胞定位：
    Lysosome membrane; Multi-pass membrane protein.
  • 蛋白家族：
    DRAM/TMEM150 family
  • 數據庫鏈接：

    HGNC: 25645

    OMIM: 610776

    KEGG: hsa:55332

    STRING: 9606.ENSP00000258534

    UniGene: Hs.525634



主站蜘蛛池模板： 国产剧情无码播放在线看| 国产xxxx99真实实拍| 亚洲色大成网站www| 欧美最猛黑人xxxx黑人猛交| 国产精品久久人妻无码网站蜜臀| 男插女高潮一区二区| 99999久久久久久亚洲| 久久中文精品无码中文字幕下载| 毛片内射久久久一区| 国模无码视频一区| 久久人人爽人人爽人人片dvd| 色欲av久久综合人妻无码 | 18禁免费吃奶摸下激烈视频| 中文字幕精品亚洲无线码一区| 欧美亚洲一区二区三区| 亚洲精品第一国产综合精品| 狠狠色噜噜狠狠狠狠米奇777| 在线a久青草视频在线观看| 国产国产乱老熟女视频网站97| 波多野结衣一区二区三区高清av| 久久婷婷五月综合色欧美蜜芽| 欧美日本日韩aⅴ在线视频| 成人无码亚洲精品无码| 国产人妖乱国产精品人妖| 凸凹人妻人人澡人人添| 24小时日本在线www免费的| 2019亚洲午夜无码天堂| 国产精品久久久久久久久鸭| 国产精品va无码一区二区| 亚洲精品美女久久久久99| 亚洲乱码日产精品bd在| 国产亚洲精品成人aa片新蒲金| 精品产区wnw2544| 新区乱码无人区二精东 | 日本国产制服丝袜一区| 欧美丰满熟妇xx猛交| 特黄特级毛片免费视频| 久久久久久成人综合网| 亚洲一区二区三区乱码在线欧洲 | 中文字幕av一区二区三区 | 成 人 免 费 黄 色|